Protein Alignment app and zdhhc5b

DIOPT Version :10

• Sequence 1: NP_648561.2
• Gene: app / 39399
• FlyBaseID: FBgn0260941
• Length: 755
• Species: Drosophila melanogaster
• Sequence 2: NP_001429732.1
• Gene: zdhhc5b / 792560
• ZFINID: ZDB-GENE-101117-1
• Length: 718
• Species: Danio rerio
• Alignment Length: 755
• Identity: 200/755 - (26%)
• Similarity: 287/755 - (38%)
• Gaps: 223/755 - (29%)

  Fly    53 ITGTSALFFAFDCPFLADSINPAIPIVGAVLYFFTMSSLLRTTFTDPGVIPRASNDEAAYIEKQI 117
            :.|.:.||..|.||:|::..:..||:...|::.||:::....||.||||.|||..||    :|:
Zfish    35 LVGATTLFLCFTCPWLSEKFSSFIPLYNVVVFLFTLANFCMATFMDPGVFPRAEEDE----DKE- 94

  Fly   118 EVPNSLNSPTYRPPPRTKEVLVKGQTVKLKYCFTCKIFRPPRASHCSLCDNCVDRFDHHCPWVGN 182
               :...:|.|      |.|.|:|..|::|:|.||:.:||||.||||:|||||:.||||||||.|
Zfish    95 ---DDFRAPLY------KTVEVRGIQVRMKWCSTCRFYRPPRCSHCSVCDNCVEEFDHHCPWVNN 150

  Fly   183 CVGKRNYRFFYLFLVSLAFLAVFIFSCSVTHLVLLMKKEHEVFNVIKAAPFTVIVVFICFFSIWS 247
            |:|:||||:|:|||:||....:.:|..|:.:::...|:...|.:.:..|...|..:|..     .
Zfish   151 CIGRRNYRYFFLFLLSLTVHIMDVFGFSLLYILHHTKQLDLVQSGVTMAVMCVAGLFFV-----P 210

  Fly   248 VIGLAGFHTYLTTSDQTTNEDLKGSFSSKGGPRTQNPYSRGNICL-NCCHILCGPMTPSLIDR-- 309
            |.||.|||..|....:||||.:.|.|  :||   .||::.|  |. |..|:||....|..:.|
Zfish   211 VAGLTGFHVVLVARGRTTNEQVTGKF--RGG---VNPFTHG--CFKNIAHVLCSSQAPRYLGRLR 268

  Fly   310 ---------------------RGIATDEFIQQ-------MQHQSS---------PRHAL------ 331
                                 .....|..|||       |:.||:         |.|..
Zfish   269 KPQSVQVQPPFLRPPLSEAQLAAKVLDNGIQQSKSSLEIMESQSTDADPPPPPKPEHRYPGLPHT 333

  Fly   332 --------------------------------------------SDVLSASHMVTTSQP------ 346
                                                        |...|.|..|||.||
Zfish   334 QNEECSLLTEAPPTPSLYKYRPAYSSPGKNHTASTHSSKMSRGNSMTESPSVPVTTGQPSYRSDP 398

  Fly   347 ---------MMGGLGGG--GIGGAGGGISIGGAELKPRFYDESNPS-----SSTLEGNGGAINGH 395
                     ..||..||  |.||.||..:.||... |.|.|....|     ||:|.....|.|..
Zfish   399 SLSSRGAAGCRGGAEGGRSGSGGLGGASAFGGRSY-PSFTDTLLQSAAASCSSSLRSAHTAHNAL 462

  Fly   396 GNGHGNGFDHPPPSYDLVQNG------KSRKHHQQRCSL--QTLLPASAQQQFKASKHKHKQLKQ 452
            |              .|:..|      ||..:..:..||  ::||..|...:|:::.|:....:.
Zfish   463 G--------------PLISEGTTSTSYKSLANQTRNGSLSYESLLTPSESPEFESAAHELSPPRP 513

  Fly   453 H-----LVAA-------------ELQQHEGG----PG---PGPNSPSL--LRSPATSSSYRLNLK 490
            |     ..||             ..||.||.    |.   |.||...|  :.||.:.:.......
Zfish   514 HPPHSLSTAAGAAPILGYTSPFLSAQQREGSLQACPAPLRPSPNRAFLRPISSPPSRAPPLSPRA 578

  Fly   491 RSLHLPLTPSYDDVRHSPLPLLHHHVHAQQTTAIGTVAAAAAAVASGASGTNTGTGTGTGGSSSS 555
            |||..|  |......|:||                   ..:.:...||...:..:.:| ||:|..
Zfish   579 RSLGSP--PPGPAPGHTPL-------------------GKSMSYGGGAELQHRPSSSG-GGTSMP 621

  Fly   556 ATTTA----PTSVSVSLATAPPPLAPRRPSTLQLQ-ASGAISASNSTLTTIHTTAPQAPAPTDFK 615
            ..|.:    |.:....|...||.|.|...|.|.|. .|.|:......|...|.....:...:..|
Zfish   622 NNTVSFFLPPMATLEFLHAHPPFLCPFPFSVLFLSLRSSAVLFPALLLPCGHKDESVSVLSSTIK 686

  Fly   616 YYSPQRSTDSNLMRNYPFPKAARGMRRQSTMSVDSQKVNI 655
            ......:|.|:        |.|||:::.|.:...:.::::
Zfish   687 QNVANHNTHSH--------KPARGVKKVSGVGGTTYEISV 718

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
app	NP_648561.2	DHHC	146..270	CDD:396215	56/123 (46%)
zdhhc5b	NP_001429732.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	306..419		17/112 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	490..522		6/31 (19%)