DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment app and zdhhc8

DIOPT Version :9

Sequence 1:	NP_648561.2	Gene:	app / 39399	FlyBaseID:	FBgn0260941	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	NP_001037871.1	Gene:	zdhhc8 / 733453	XenbaseID:	XB-GENE-976023	Length:	776	Species:	Xenopus tropicalis

Alignment Length:	838	Identity:	208/838 - (24%)
Similarity:	334/838 - (39%)	Gaps:	247/838 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 LITGTSALFFAFDCPFLADSINPAIPIVGAVLYFFTMSSLLRTTFTDPGVIPRASNDEAAYIEKQ 116
            |:.|::.|||.|.||:|...|:||||:...:::.|.:::....||.|||:.|||..||
Frog    23 LLVGSTTLFFVFTCPWLTREISPAIPVYNGLMFLFVLANFSMATFMDPGIFPRADEDE------- 80

  Fly   117 IEVPNSLNSPTYRPPPRTKEVLVKGQTVKLKYCFTCKIFRPPRASHCSLCDNCVDRFDHHCPWVG 181
             :..:...:|.|      |.|.:|...|::|:|.||..:||||.||||:|||||:.||||||||.
Frog    81 -DKDDDFRAPLY------KNVEIKRIQVRMKWCATCHFYRPPRCSHCSVCDNCVEDFDHHCPWVN 138

  Fly   182 NCVGKRNYRFFYLFLVSLAFLAVFIFSCS---VTHLVLLMKKEHEVFNVIKAAPFTVIVVFICFF 243
            ||:|:||||:|:|||:||:...:.:||..   |.|.:.::.:.|        ...|:.|:.:...
Frog   139 NCIGRRNYRYFFLFLLSLSTHMIGVFSFGLIFVLHHLEVLGEAH--------TSITISVMCVAGL 195

  Fly   244 SIWSVIGLAGFHTYLTTSDQTTNEDLKGSFSSKGGPRTQNPYSRGNICLNCCHILCGPMTPSLI- 307
            ....||||.|||..|....:||||.:.|.|  :||   .||::|| .|.|..|:||.|::|..|
Frog   196 FFIPVIGLTGFHIVLVVRGRTTNEQVTGKF--RGG---VNPFTRG-CCGNIQHVLCSPLSPRYIV 254

  Fly   308 ---DRRGIA--------------------TDEFIQQMQHQSSPRHALSDVLSASHMVTTSQP--- 346
               .|..:|                    :|..||...|:|..:.:|..:...|..:.|..|
Frog   255 DPKKRPSVALKPPFIRPDVLSERQITVKISDNGIQANLHRSKSKGSLEGINDKSLELQTMLPKGD 319

  Fly   347 ------MMGGLGGGGIGGAGGGISIGGAELKPRFYDESNPSSSTLEGNGGAINGHGNGH------ 399
                  |.|.:           ::...:.|.|:..:..||::..:.......:.:...|
Frog   320 PNKYSDMKGSV-----------VTSEESSLSPKIINPPNPATPAMYKYRPPFSTNSKVHYHTATE 373

  Fly   400 ---------GNGF--------DH-PPPSYDLVQNGKSRKHHQQRCSLQTLLPASAQQQFKASKHK 446
                     .|.|        |: ..|:.|:.:..|:..|...:.|...:.|.:|..:..:.|:.
Frog   374 QIAVQEGLQDNMFLEDDCRSTDYQSEPNLDIPEYRKNSLHKSYQSSPLQIDPFAANSRSLSLKNS 438

  Fly   447 HKQLKQHLVAAELQQHEGG---PGPGPNSPSLLRSPATSSSYRLNLKRSLHLPLTPS-------- 500
            .::..:.| ..:|.:.|||   |.....||:.|.:...|.||     .||..|::|:
Frog   439 GRRESEKL-PLQLVKSEGGTITPYKSVFSPNALSNRNGSLSY-----DSLLNPMSPAAKCTTQTA 497

  Fly   501 -----------------------------------------------YDDVRHSPL--------- 509
                                                           ||::..|.:
Frog   498 AGSVGYHSPYMSAKMCHLRSGERQVAHGFSPVLSRAAEHQREPSPVRYDNLSKSIMASIQERKEM 562

  Fly   510 ----PLLHHHVHA----------QQTTAIGTVAAAAAAVASGASGT--NTGTGTGTGGSSSSATT 558
                .|||.|..:          ..|.::..|::.:....:|..|:  |...|..:..|.:....
Frog   563 EEREKLLHSHTDSVFADSGVYDTPSTYSLQQVSSLSENPRAGRYGSKDNLLAGAPSFSSRNPVLQ 627

  Fly   559 TAPTSVSVSLATAPPPLAPRRPSTLQLQASGAISASNSTLTTIHTTAPQAPAPTDFKYYSPQR-- 621
            ::.:|:|.:::.||      |.||..|||.   .|:|:    |.:..|.....::..|.||..
Frog   628 SSVSSLSSAVSRAP------RTSTTSLQAD---LANNN----IQSHQPLQARVSNGSYKSPGHQA 679

  Fly   622 -STDSNLMRNYPFPKAARGMRRQSTM------SVDSQKVNIAGYQPLPMRKPYKHQEVMFELKSP 679
             |:.|.:.|: |....|:.:...:||      |:..|:      :.|.::.|  |.:|..:.|.
Frog   680 PSSPSGMPRS-PSYGGAKAVTFLNTMEFGEGTSMPIQR------EDLQVKPP--HGKVNGQPKG- 734

  Fly   680 TNRLTIRECDFGGGGEPCDDDQSIKDSQIFRVSKRNLYMNHRSPWKERDRYSNLYEYS 737
               |...||..|          |...||          .|..||    .|:||:.:.|
Frog   735 ---LARAECRLG----------STSSSQ----------GNTVSP----SRHSNVKKVS 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
app	NP_648561.2	zf-DHHC	146..270	CDD:279823	57/126 (45%)
zdhhc8	NP_001037871.1	DHHC	99..224	CDD:366691	58/132 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	206	1.000	Inparanoid score	I3618
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1264614at2759
OrthoFinder	1	1.000	-	-		FOG0000285
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R405
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.090