DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment app and Zdhhc4

DIOPT Version :9

Sequence 1:	NP_648561.2	Gene:	app / 39399	FlyBaseID:	FBgn0260941	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	NP_082655.1	Gene:	Zdhhc4 / 72881	MGIID:	1920131	Length:	343	Species:	Mus musculus

Alignment Length:	342	Identity:	99/342 - (28%)
Similarity:	139/342 - (40%)	Gaps:	90/342 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 CSNMAPN--QRV--TRKWELFAGRN-KFYCDGLLMSAPHTGVFY--LTCILITGTSALFFAFD-- 64
            ||.:.|.  ||.  |...:||..|: .|....||:.    |:.|  .||.:......|.|:..
Mouse    41 CSRVIPQCLQRAVQTLLHQLFHTRHPTFIVLHLLLQ----GLVYAEYTCEVFGYCRELEFSLPYL 101

  Fly    65 -CPFLADSINPAIPIVGAVLYFFTMSSLLRTTFTDPGVIPRASNDEAAYIEKQIEVPNSLNSPTY 128
             .|::..|:|         |.|||:     |...:||.|.:|:......:.|..:|....||
Mouse   102 LLPYVLLSVN---------LVFFTL-----TCAANPGTITKANESFLLQVYKFDDVMFPKNS--- 149

  Fly   129 RPPPRTKEVLVKGQTVKLKYCFTCKIFRPPRASHCSLCDNCVDRFDHHCPWVGNCVGKRNYRFFY 193
                               .|.||.:.:|.|:.||.|||.||.||||||.||.||:|..|.|:|.
Mouse   150 -------------------RCPTCDLRKPARSKHCRLCDRCVHRFDHHCVWVNNCIGAWNTRYFL 195

  Fly   194 LFLVSLAFLAVFIFSCSVTHLVLLMKKE------------HEVFNVIKAAPFTVIVVFICFFSIW 246
            ::|::|...|..|.:.:...|:.|:...            |  |..:... |.:..:|:.|..|.
Mouse   196 IYLLTLTASAATIATVTAAFLLRLVTVSDLYQETYLDDVGH--FQAVDTV-FLIQHLFLAFPRIV 257

  Fly   247 SVIG--------LAG---FHTYLTTSDQTTNEDLKG-----------SFSSKGGPRT-QNPYSRG 288
            .::|        |||   |..||..::|||||..||           ::|....||. ||.:|.|
Mouse   258 FLLGFVIVLSMLLAGYLCFALYLAATNQTTNEWYKGDWAWCQRWPLVAWSPSAEPRIHQNIHSHG 322

  Fly   289 NICLNCCHILCGPMTPS 305
             ...|...|.. |.|||
Mouse   323 -FRSNLREIFL-PATPS 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
app	NP_648561.2	zf-DHHC	146..270	CDD:279823	50/146 (34%)
Zdhhc4	NP_082655.1	DHHC	151..292	CDD:396215	50/143 (35%)
Zdhhc4	NP_082655.1	Di-lysine motif. /evidence=ECO:0000250\|UniProtKB:Q9NPG8	340..343
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R405
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840