DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment app and Zdhhc11

DIOPT Version :9

Sequence 1:	NP_648561.2	Gene:	app / 39399	FlyBaseID:	FBgn0260941	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	NP_081980.1	Gene:	Zdhhc11 / 71164	MGIID:	1918414	Length:	347	Species:	Mus musculus

Alignment Length:	253	Identity:	69/253 - (27%)
Similarity:	102/253 - (40%)	Gaps:	63/253 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 VFYLTCILITGTSALFFAFDCPFLADSINPAIPIV-GAVLYFFTMSSLLRTTFTDPGVIPRASND 108
            :.||...::|      |....|||..|...|..|| |.|..|..:..|:..|. ||.       |
Mouse    50 ITYLAMSIVT------FGIFIPFLPYSWKYAANIVMGGVFIFHLIVHLIAITI-DPA-------D 100

  Fly   109 EAAYIEKQIEVPNSLNSPTYRPPPRTKEVLVKGQTVKLKYCFTCKIFRPPRASHCSLCDNCVDRF 173
            ....::|....|    .|.:   .|:|...|    ::.:||..|::....:|.|||.|:.||..|
Mouse   101 TNVRLKKDYTQP----VPAF---DRSKHTHV----IQNQYCHLCEVTASKKAKHCSACNKCVSGF 154

  Fly   174 DHHCPWVGNCVGKRNYRFFYLFLVSLA--FLAVFIFSCSVTHLVLLMKKEHEVFNVIKAAPFTVI 236
            ||||.|:.||||:|||.||:..:.|.|  .|.|.|..|.:.....:...|      ::..|....
Mouse   155 DHHCKWLNNCVGRRNYWFFFWSVASAAVGILGVMIILCYICIQYFVNPDE------LRTDPLYKE 213

  Fly   237 VV----FICFFSIWSV----------------IGLAG---------FHTYLTTSDQTT 265
            ::    ::.|.|:|.|                :.:|.         ||.||.|.:.:|
Mouse   214 IISENTWLLFLSLWPVPVKTPIVLSIAVMALLLAIASFVMLGHLLIFHLYLITKNMST 271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
app	NP_648561.2	zf-DHHC	146..270	CDD:279823	44/151 (29%)
Zdhhc11	NP_081980.1	zf-DHHC	123..277	CDD:279823	45/159 (28%)
Zdhhc11	NP_081980.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	291..332
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810