Protein Alignment app and Zdhhc1

DIOPT Version :9

• Sequence 1: NP_648561.2
• Gene: app / 39399
• FlyBaseID: FBgn0260941
• Length: 755
• Species: Drosophila melanogaster
• Sequence 2: NP_001365935.1
• Gene: Zdhhc1 / 70796
• MGIID: 1918046
• Length: 484
• Species: Mus musculus
• Alignment Length: 476
• Identity: 105/476 - (22%)
• Similarity: 155/476 - (32%)
• Gaps: 162/476 - (34%)

  Fly   148 YCFTCKIFRPPRASHCSLCDNCVDRFDHHCPWVGNCVGKRNYRFFYLFLVSLAFLAVFIFSCSVT 212
            :|..|.:....|:.|||.|:.||..|||||.|:.||||:||||.| |..|:.|.|.|.:.....|
Mouse   132 HCNLCDVDVSARSKHCSACNKCVCGFDHHCKWLNNCVGERNYRLF-LHSVASALLGVLLLVLVAT 195

  Fly   213 HLVL--------LMKKEHEVFNVIKAAPFTVIVVFICFFSIWSVIGLAGFHTYLTTSDQTTNEDL 269
            ::.:        |...:|  |.|:|.           ...:|.|
Mouse   196 YVFVEFFVNPMRLRTNQH--FEVLKN-----------HTDVWFV--------------------- 226

  Fly   270 KGSFSSKGGPRTQNPYSRGNICLNCCHILCGPMTPSLIDR----------RGIATDEFIQQMQHQ 324
               |.......||.|   ..:.|....||.|.::.:|:..          ..:.|.|:|.|.:..
Mouse   227 ---FLPAAPVETQAP---AILALAALLILLGLLSTALLGHLLCFHIYLMWHKLTTYEYIVQHRPA 285

  Fly   325 SSPRHALSDVLSASHMVTTSQPMMGGLGGGGIGGAGGGISIGGAELKPRFYDESNPSSSTLEGNG 389
            ...:....::.|....|.:.|.|                         .||..:
Mouse   286 QEAKETHKELESCPRKVRSIQEM-------------------------EFYMRT----------- 314

  Fly   390 GAINGHGNGHGNGFDH--PPPSYDLVQNGKSRKHHQQRCSLQTLLPASAQQQFKASKHKHKQLKQ 452
                         |.|  |.||      |::|          |....:...||.|:
Mouse   315 -------------FSHVRPEPS------GQAR----------TAALNANPSQFLAT--------- 341

  Fly   453 HLVAAELQQHEGGPGPGPNSPSLLRSPATSSSYRLNLKRSLHLPLTPSYDDVRHSPLPLLHHHVH 517
                    |.:..| |.|:|...|..|......:...:|...||.:...|  |..|||.|..
Mouse   342 --------QGQVEP-PLPSSSDTLALPPRIQPQKKRKRRVYRLPRSGVLD--RELPLPRLRE--- 392

  Fly   518 AQQTTAIGTVAAAAAAVASGASGTNTGTGTGTGGSSSSATTTAPTSVSVS-----LATAPPPLAP 577
                  .||.:..:::.:...|.:....| |:.|:..||:..:...:.|:     .|....|.|.
Mouse   393 ------TGTPSRRSSSSSDSTSASPVHAG-GSAGAYYSASAESMEEIPVAQTRLGSAALGAPGAR 450

  Fly   578 RRPSTLQLQA-SGAISASNST 597
            .|.|.|.||| |.|:..|.|:
Mouse   451 GRESGLALQARSPAVFVSPSS 471

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
app	NP_648561.2	zf-DHHC	146..270	CDD:279823	37/129 (29%)
Zdhhc1	NP_001365935.1	Mediates interaction with STING1. /evidence=ECO:0000250|UniProtKB:Q8WTX9	1..268		46/176 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..38
		DHHC	126..281	CDD:396215	49/189 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	341..415		19/102 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	444..484		12/28 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910