Protein Alignment app and zdhhc5a

DIOPT Version :10

• Sequence 1: NP_648561.2
• Gene: app / 39399
• FlyBaseID: FBgn0260941
• Length: 755
• Species: Drosophila melanogaster
• Sequence 2: XP_005160301.1
• Gene: zdhhc5a / 571795
• ZFINID: ZDB-GENE-090312-92
• Length: 760
• Species: Danio rerio
• Alignment Length: 714
• Identity: 200/714 - (28%)
• Similarity: 283/714 - (39%)
• Gaps: 182/714 - (25%)

  Fly    53 ITGTSALFFAFDCPFLADSINPAIPIVGAVLYFFTMSSLLRTTFTDPGVIPRASNDEAAYIEKQI 117
            :.|::.|||.|.||:|::..:.|:||...|::.|.:::....||.|||:.|||..||    :|:
Zfish    41 LVGSTTLFFCFTCPWLSEQFSVAVPIYNGVMFMFVLANFCMATFMDPGIFPRAEEDE----DKE- 100

  Fly   118 EVPNSLNSPTYRPPPRTKEVLVKGQTVKLKYCFTCKIFRPPRASHCSLCDNCVDRFDHHCPWVGN 182
               :...:|.|      |.|.::|..|::|:|.||:.:||||.||||:|||||:.||||||||.|
Zfish   101 ---DDFRAPLY------KTVEIRGIQVRMKWCSTCRFYRPPRCSHCSVCDNCVEDFDHHCPWVNN 156

  Fly   183 CVGKRNYRFFYLFLVSLA--FLAVFIFSCSVTHLVLLMKKEHEVFNVIKAAPFTVIVVFICFFSI 245
            |:|:||||:|:|||:||.  .:.||.|.     |:.::....::..|..|....|:.|...||.
Zfish   157 CIGRRNYRYFFLFLLSLTAHIMGVFGFG-----LLFILYHTQQLDRVHSAVTMAVMCVAGLFFI- 215

  Fly   246 WSVIGLAGFHTYLTTSDQTTNEDLKGSFSSKGGPRTQNPYSRGNICL-NCCHILCGPMTPSLIDR 309
             .|.||.|||..|....:||||.:.|.|  :||   .||::.|  || |..|:||....|..:.|
Zfish   216 -PVAGLTGFHVVLVARGRTTNEQVTGKF--RGG---VNPFTNG--CLRNVSHVLCSSQAPRYLGR 272

  Fly   310 RGIATDEFIQQ--MQHQSSPRHALSDVLSASHMVTTSQPMMGGLGGGGIGGAGGGISIGGAELKP 372
            :..|....:|.  ::.|.:.....:.||.                 .||.|
Zfish   273 KRKAQTVSVQPPFLRPQLTEAQLAAKVLD-----------------NGIQG-------------- 306

  Fly   373 RFYDESNPSSSTLEGNGGAINGHGNGHGNGFDHPPPSYDLVQNGKSR--KHHQQRCSLQTLLPAS 435
                :.:.|.|:||       ...:...:....|||..:|...|.||  ..|.:..||....|.:
Zfish   307 ----DLHRSKSSLE-------MMESQSADAEPPPPPKPELRYPGLSRGPAGHSEESSLLNKAPPT 360

  Fly   436 AQQQFKASKHKHKQLKQH--LVAAELQQHEGGPGPGPNSPSLLRSPATSSSYRLNLKRSLHLPLT 498
             ...||.........|.|  |..|...|...|.....:|.|||:| :....||..
Zfish   361 -PTMFKYRPTYSSPGKNHTALTHAYANQMSRGDSLKESSSSLLQS-SQQPGYRSE---------- 413

  Fly   499 PSYDDVRHSPLPLLHHHVHAQQTTAIGTVAAAAAAVASGASGTNTGTG--TGTG------GSSSS 555
            ||.|.                        .....|..|||..|..|.|  .|:|      |..|.
Zfish   414 PSLDG------------------------REGGGAERSGAERTGGGPGGPPGSGIPGYSLGGRSY 454

  Fly   556 ATTTAPT--------SVSV-SLATAPPPLAPRRPSTLQLQASGAISASNSTLTTIHTTAPQAPAP 611
            .:.:.||        |.|| |...|||..|               :.|.|..:..:.|.|||...
Zfish   455 PSFSDPTVLAERASRSSSVRSTHNAPPSEA---------------TTSTSYKSLANQTPPQAARN 504

  Fly   612 TDFKYYS---PQRSTDSNLMRNYPFPKAARGMRRQSTMSVDSQKVNIAGY-------QPLPMRKP 666
            ....|.|   |..|.|        |..||      ..||....:..:.||       |....|:.
Zfish   505 GSLSYDSLLTPSESPD--------FESAA------PEMSPGRPRTPVVGYSSPFLSAQIAHQREA 555

  Fly   667 YKHQEVMFE---LKSPTNRLTIRECDFGGGGEPC----DDDQSIKDSQIFRVSKRNLYMNHRSP 723
            ..||.|...   :.||.:.:.:|    |.|..|.    :.::.:.|||.......:.:.:|..|
Zfish   556 ELHQPVASSSALMASPQHAVFLR----GSGSPPVPPERERERLLHDSQAQHHHHHHHHHHHHRP 615

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
app	NP_648561.2	DHHC	146..270	CDD:396215	59/125 (47%)
zdhhc5a	XP_005160301.1	DHHC	116..241	CDD:396215	60/131 (46%)