Protein Alignment app and zdhhc1

DIOPT Version :10

• Sequence 1: NP_648561.2
• Gene: app / 39399
• FlyBaseID: FBgn0260941
• Length: 755
• Species: Drosophila melanogaster
• Sequence 2: NP_001410714.1
• Gene: zdhhc1 / 562614
• ZFINID: ZDB-GENE-130925-1
• Length: 578
• Species: Danio rerio
• Alignment Length: 663
• Identity: 146/663 - (22%)
• Similarity: 222/663 - (33%)
• Gaps: 231/663 - (34%)

  Fly    81 AVLYFFTMSSLLRTTFTDPGVI--------------PRASNDEAAYIEKQIEVPNSLNSPTYRPP 131
            ||..|.....||.|.:...|.|              ...|.|.|.|         ::.:.:|:.|
Zfish    52 AVTGFGVFVPLLPTHWIPAGYICTGITFVCHLFMHLMAVSIDPADY---------NVRAKSYKGP 107

  Fly   132 ----PRTKEVLVKGQTVKLKYCFTCKIFRPPRASHCSLCDNCVDRFDHHCPWVGNCVGKRNYRFF 192
                .|||...|    ::..:|:.|::...|::.|||.|:.||..|||||.|:.||||.|||
Zfish   108 MPVFDRTKHAHV----IENCHCYLCEVDVGPKSKHCSACNKCVASFDHHCRWLNNCVGSRNY--- 165

  Fly   193 YLFLVSL--AFLAVFIFSCSVTHLVLLMKKEHEVFNVIKAAPFTVIVVFICFF------------ 243
            :|||.|:  |.|.:.:                    |:..|.:    |||.||
Zfish   166 WLFLNSVISALLGIVL--------------------VVVIASY----VFIEFFLDPSKLRSDKHF 206

  Fly   244 -------SIWSVIGLAGFHTYLTTSDQTTNEDLKGSFSSKGGPRTQNPYSRG-NICLNCC----- 295
                   .:|.|        :|..:..||           .||..  |...| .|.|...
Zfish   207 QQVRNESVVWFV--------FLPVAPVTT-----------AGPAI--PALAGVTIALGLLSALLL 250

  Fly   296 -HILCGPMTPSLIDRRGIATDEFIQQMQHQSSPRHALSDVLSASHMVTTSQPMMGGLGGGGIGGA 359
             |:||..:  .|:..| ::|.|:|.:.:|:.
Zfish   251 GHLLCFHI--YLMWNR-LSTYEYIVRQRHRQ---------------------------------- 278

  Fly   360 GGGISIGGAELKPRFYDESNPSSSTLE---GNGGAINGHGNGHGNGFDHP-----PPSYDLVQNG 416
                ..|.:...|...|...|..:.::   ...|.:         |:.:|     .|.....|.|
Zfish   279 ----EAGDSRKPPPENDSGVPKLNLIKQQVSYSGTL---------GYTNPEMEVEDPKAMTSQEG 330

  Fly   417 KSRKHHQQ-RCSLQTL-----LPASAQQQFKAS--KHKHKQLKQHLV---AAELQ---------- 460
            .:|..:.: |||.:.:     ||:...:| |||  .|||.|.|:..|   |||:.
Zfish   331 AARYGNGRIRCSSEHMDEEEHLPSVLTEQ-KASPHPHKHAQKKKRKVRKLAAEVNGDISIDTSTA 394

  Fly   461 --------QHEGGPGPGPNSPSL-LRSPATSSSYRLNLKRSLHLPLTPSYDDVRHSPLPLLHHHV 516
                    :.|........|.|| .|.|..:...|.:|.     ||.|    |:.:..|..:|..
Zfish   395 KGLQKTSAEKESSVAAATVSSSLGQRLPFPAFPLRASLP-----PLAP----VQAAGPPAEYHSD 450

  Fly   517 HAQQTTAIGTVAAAAAAVASGASGTNTGTGTGTGGSSSSATTTAPTSVSVSLATAPPPLAPRRPS 581
            .|:....|....|...:.|...:...|.|.|.:...||......|:|.:...|.:|.|...|:.:
Zfish   451 SAESLEEIPVAMARLGSAALAGAQIPTTTATASSSYSSMLQCALPSSAAGHAAPSPQPRTKRKTA 515

  Fly   582 --TLQLQASGAISASNSTLTTIHTTAPQAPAPTDFKYYSPQRSTDSNLMRNYPFPKAAR----GM 640
              |:..|....:..:.|...|..:..|..|         |:.|           |:||:    |.
Zfish   516 ARTVSEQRFEMLYHNPSMFMTRESGEPAIP---------PEES-----------PRAAKRKQTGK 560

  Fly   641 RRQSTMSVDSQKV 653
            :|.:..:..|.:|
Zfish   561 KRNTEDAKPSSRV 573

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
app	NP_648561.2	DHHC	146..270	CDD:396215	40/144 (28%)
zdhhc1	NP_001410714.1	DHHC	118..274	CDD:396215	55/210 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	278..298		4/57 (7%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	345..376		11/31 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	497..517		5/19 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	532..578		13/62 (21%)