Protein Alignment app and ZDHHC4

DIOPT Version :10

• Sequence 1: NP_648561.2
• Gene: app / 39399
• FlyBaseID: FBgn0260941
• Length: 755
• Species: Drosophila melanogaster
• Sequence 2: NP_001358221.1
• Gene: ZDHHC4 / 55146
• HGNCID: 18471
• Length: 359
• Species: Homo sapiens
• Alignment Length: 334
• Identity: 83/334 - (24%)
• Similarity: 138/334 - (41%)
• Gaps: 98/334 - (29%)

  Fly     1 MNLLCCCCCSNMAPNQRVTRKWELFAGRNKFYC----------DGLLMSAPHT--GVFYLTCILI 53
            |.|:..|.||.....:.:.|     .|...|.|          .|||....||  ..|.:..:::
Human    16 MGLVLICVCSKTHSLKGLAR-----GGAQIFSCIIPECLQRAVHGLLHYLFHTRNHTFIVLHLVL 75

  Fly    54 TGTSALFFAFD----CPFLADSIN----PAIPIVGAVLYFFTMSSLLRTTFTDPGVIPRASNDEA 110
            .|.....:.::    |..|..|::    |.: ::|..|:|||:     |..|:||:|.:|  :|.
Human    76 QGMVYTEYTWEVFGYCQELELSLHYLLLPYL-LLGVNLFFFTL-----TCGTNPGIITKA--NEL 132

  Fly   111 AYIE----KQIEVPNSLNSPTYRPPPRTKEVLVKGQTVKLKYCFTCKIFRPPRASHCS------- 164
            .::.    .::..|.::.                        |.||.:.:|.|:.|||
Human   133 LFLHVYEFDEVMFPKNVR------------------------CSTCDLRKPARSKHCSECGSRDS 173

  Fly   165 --------LCDNCVDRFDHHCPWVGNCVGKRNYRFFYLFLVSLAFLAVFIFSCSVT---HLVLLM 218
                    :|:.||.||||||.||.||:|..|.|:|.:::::|...|..:...|.|   |||::.
Human   174 SGTSNSTCVCNWCVHRFDHHCVWVNNCIGAWNIRYFLIYVLTLTASAATVAIVSTTFLVHLVVMS 238

  Fly   219 KKEHEVF-------NVIKAAPFTVIVVFICFFSIWSVIG--------LAG---FHTYLTTSDQTT 265
            ....|.:       :|:... |.:..:|:.|..|..::|        |.|   |..||..::|||
Human   239 DLYQETYIDDLGHLHVMDTV-FLIQYLFLTFPRIVFMLGFVVVLSFLLGGYLLFVLYLAATNQTT 302

  Fly   266 NEDLKGSFS 274
            ||..:|.::
Human   303 NEWYRGDWA 311

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
app	NP_648561.2	DHHC	146..270	CDD:396215	49/159 (31%)
ZDHHC4	NP_001358221.1	DHHC	151..307	CDD:396215	49/156 (31%)