DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment app and ZDHHC4

DIOPT Version :9

Sequence 1:	NP_648561.2	Gene:	app / 39399	FlyBaseID:	FBgn0260941	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	NP_001358221.1	Gene:	ZDHHC4 / 55146	HGNCID:	18471	Length:	359	Species:	Homo sapiens

Alignment Length:	334	Identity:	83/334 - (24%)
Similarity:	138/334 - (41%)	Gaps:	98/334 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNLLCCCCCSNMAPNQRVTRKWELFAGRNKFYC----------DGLLMSAPHT--GVFYLTCILI 53
            |.|:..|.||.....:.:.|     .|...|.|          .|||....||  ..|.:..:::
Human    16 MGLVLICVCSKTHSLKGLAR-----GGAQIFSCIIPECLQRAVHGLLHYLFHTRNHTFIVLHLVL 75

  Fly    54 TGTSALFFAFD----CPFLADSIN----PAIPIVGAVLYFFTMSSLLRTTFTDPGVIPRASNDEA 110
            .|.....:.::    |..|..|::    |.: ::|..|:|||:     |..|:||:|.:|  :|.
Human    76 QGMVYTEYTWEVFGYCQELELSLHYLLLPYL-LLGVNLFFFTL-----TCGTNPGIITKA--NEL 132

  Fly   111 AYIE----KQIEVPNSLNSPTYRPPPRTKEVLVKGQTVKLKYCFTCKIFRPPRASHCS------- 164
            .::.    .::..|.::.                        |.||.:.:|.|:.|||
Human   133 LFLHVYEFDEVMFPKNVR------------------------CSTCDLRKPARSKHCSECGSRDS 173

  Fly   165 --------LCDNCVDRFDHHCPWVGNCVGKRNYRFFYLFLVSLAFLAVFIFSCSVT---HLVLLM 218
                    :|:.||.||||||.||.||:|..|.|:|.:::::|...|..:...|.|   |||::.
Human   174 SGTSNSTCVCNWCVHRFDHHCVWVNNCIGAWNIRYFLIYVLTLTASAATVAIVSTTFLVHLVVMS 238

  Fly   219 KKEHEVF-------NVIKAAPFTVIVVFICFFSIWSVIG--------LAG---FHTYLTTSDQTT 265
            ....|.:       :|:... |.:..:|:.|..|..::|        |.|   |..||..::|||
Human   239 DLYQETYIDDLGHLHVMDTV-FLIQYLFLTFPRIVFMLGFVVVLSFLLGGYLLFVLYLAATNQTT 302

  Fly   266 NEDLKGSFS 274
            ||..:|.::
Human   303 NEWYRGDWA 311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
app	NP_648561.2	zf-DHHC	146..270	CDD:279823	49/159 (31%)
ZDHHC4	NP_001358221.1	DHHC	151..307	CDD:366691	49/156 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R405
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940