DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment app and ZDHHC3

DIOPT Version :9

Sequence 1:NP_648561.2 Gene:app / 39399 FlyBaseID:FBgn0260941 Length:755 Species:Drosophila melanogaster
Sequence 2:XP_016862050.1 Gene:ZDHHC3 / 51304 HGNCID:18470 Length:378 Species:Homo sapiens


Alignment Length:294 Identity:75/294 - (25%)
Similarity:118/294 - (40%) Gaps:81/294 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    48 LTCILITGTSALFFAFDCPF--LADSINPAIPIVGAVLY----FFTMSSLLRTTFTDPGVIPRAS 106
            :.|.::|....|:..|...|  |..|.:....|:..:::    |..::|..|...||||.:|: .
Human    45 IACAIVTWFLVLYAEFVVLFVMLIPSRDYVYSIINGIVFNLLAFLALASHCRAMLTDPGAVPK-G 108

  Fly   107 NDEAAYIEKQIEVPNSLNSPTYRPPPRTKEVLVKGQTVKLKY-CFTCKIFRPPRASHCSLCDNCV 170
            |....:||       ||.             |..||.|   | |..|...:|.||.|||:|..|:
Human   109 NATKEFIE-------SLQ-------------LKPGQVV---YKCPKCCSIKPDRAHHCSVCKRCI 150

  Fly   171 DRFDHHCPWVGNCVGKRNYRFFYLFLVSLAFLAVFIFSCSVTHLVLLMKKE-------------- 221
            .:.|||||||.||||:.|.::|.||.:.:|.:::........|.:...:::              
Human   151 RKMDHHCPWVNNCVGENNQKYFVLFTMYIALISLHALIMVGFHFLHCFEEDWTTYGLNREEMAET 215

  Fly   222 ----HEVFNVIK---------AAPFTVI-VVFICF----FSIWSVIGLAGFHTYLTTSDQTTNED 268
                ||....:.         :.|.||| ::.:||    |.|::.: :.|...:...:|:|... 
Human   216 GISLHEKMQPLNFSSTECSSFSPPTTVILLILLCFEGLLFLIFTSV-MFGTQVHSICTDETKRW- 278

  Fly   269 LKGSFSSKGGPRTQNPYSR-GNICLNCCHILCGP 301
                       |.|.|..| ..:|..|    |||
Human   279 -----------RKQCPQWRVKGLCAGC----CGP 297

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
appNP_648561.2 zf-DHHC 146..270 CDD:279823 41/156 (26%)
ZDHHC3XP_016862050.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5273
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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