DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment app and Zdhhc17

DIOPT Version :9

Sequence 1:	NP_648561.2	Gene:	app / 39399	FlyBaseID:	FBgn0260941	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	NP_001034429.1	Gene:	Zdhhc17 / 366889	RGDID:	1595790	Length:	622	Species:	Rattus norvegicus

Alignment Length:	333	Identity:	81/333 - (24%)
Similarity:	140/333 - (42%)	Gaps:	83/333 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 WELFAGRNKFYCDGLLMSAPHTGVF-------YLTCILITGTSALFFAFDCPFLADSINPAIPIV 79
            |......:|.:.|..:.||...|::       |:|..........|.:...||||:|:
  Rat   329 WATVQFLSKSFFDHSMHSALPLGIYLATKFWMYVTWFFWFWNDLSFLSIHLPFLANSV------- 386

  Fly    80 GAVLYFFTMSSLLRTTFTDPGVIPRASNDEAAYIEKQIEVPNSLNSPTYRPPPRTKEVLVKGQTV 144
             |:.|.|.     ::..:|||:| :|:.::                       :.|.::...:|.
  Rat   387 -ALFYNFG-----KSWKSDPGII-KATEEQ-----------------------KKKTIVELAETG 421

  Fly   145 KLK---YCFTCKIFRPPRASHCSLCDNCVDRFDHHCPWVGNCVGKRNYRFFYLFLVSLAFLAVF- 205
            .|.   :|.||.|.:|.|:.||.:|:.|:.:||||||||||||...|:|:|..:|..|.|:..:
  Rat   422 SLDLSIFCSTCLIRKPVRSKHCGVCNRCIAKFDHHCPWVGNCVCAGNHRYFMGYLFFLLFMICWM 486

  Fly   206 IFSCSVTHLVLLMKKEHE-------VFNVIKAAPFTVIVVFI--CFFSIWSVIGLAGFHTYLTTS 261
            |:.| |::..|..:..:.       :..:...:|: :..:|:  .|..:|..:.|......:|..
  Rat   487 IYGC-VSYWGLHCETTYTKDGFWTYITQIATCSPW-MFWMFLNSVFHFMWVAVLLMCQMYQITCL 549

  Fly   262 DQTTNEDL--------KGSFSSKGGPRTQNPYSRG---NIC----LNCCHILCGPMTPSLIDRRG 311
            ..||||.:        |.:.:|     .::|::.|   ||.    ..|    ||...|.::|...
  Rat   550 GITTNERMNARRYKHFKVTTTS-----IESPFNHGCVRNIIDFFEFRC----CGLFRPVIVDWTR 605

  Fly   312 IATDEFIQ 319
            ..|.|:.|
  Rat   606 QYTIEYDQ 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
app	NP_648561.2	zf-DHHC	146..270	CDD:279823	43/144 (30%)
Zdhhc17	NP_001034429.1	Necessary and sufficient for interaction with DNAJC5 and SNAP25. /evidence=ECO:0000250\|UniProtKB:Q80TN5	1..295
		Ank_4	<60..100	CDD:290365
		ANK	77..192	CDD:238125
		ANK repeat	79..110	CDD:293786
		Ank_2	84..177	CDD:289560
		ANK repeat	112..144	CDD:293786
		ANK	143..267	CDD:238125
		ANK repeat	146..177	CDD:293786
		Ank_2	151..245	CDD:289560
		ANK repeat	179..211	CDD:293786
		ANK repeat	214..245	CDD:293786
		zf-DHHC	428..558	CDD:279823	42/131 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810