DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment app and Patsas

DIOPT Version :9

Sequence 1:	NP_648561.2	Gene:	app / 39399	FlyBaseID:	FBgn0260941	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	NP_001356957.1	Gene:	Patsas / 34634	FlyBaseID:	FBgn0029137	Length:	613	Species:	Drosophila melanogaster

Alignment Length:	266	Identity:	79/266 - (29%)
Similarity:	114/266 - (42%)	Gaps:	92/266 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 AIPIVGAVL-----YFFTMSSLLRTTFT-----DPGVIPRASNDEAAYIE--KQIEVPNSLNSPT 127
            ||||...:|     .|...::::..::.     |||.||.:|:   ||..  |||        |.
  Fly   387 AIPITWNILRRSHYCFIYWNAVMWISWAIANRRDPGYIPLSSD---AYYRAIKQI--------PY 440

  Fly   128 YRPPPRTKEVLVKGQTVKLKYCFTCKIFRPPRASHCSLCDNCVDRFDHHCPWVGNCVGKRNYRFF 192
            :       :.|.|...:..:.|.:|:..||.||.||.:|:.||..||||||::.||||.||..:|
  Fly   441 F-------DKLKKRNVMLTRLCHSCRCLRPLRAKHCRVCNRCVSYFDHHCPFIYNCVGLRNRMWF 498

  Fly   193 YLFLVSLAFLAVFIFSCSVTHLVLLMKKEHEVFNVIKAAPFTVIVVFICF------FSIWSVIGL 251
            :||::|:|      .:||.|                        :.|.|:      |::..|:||
  Fly   499 FLFVLSVA------VNCSFT------------------------IYFACYCVMIEGFTMLYVLGL 533

  Fly   252 ------AGFHTYLTTS-------DQTTNEDLKGSFSSKGGP-------RTQNPYSRGNICLNCCH 296
                  .|....||.:       :.||||    .|:.|..|       |.|||:|||.| ||...
  Fly   534 IEAVVFCGLGWILTCTSILHACMNLTTNE----MFNYKRYPYLRDKRGRYQNPFSRGPI-LNLLE 593

  Fly   297 -ILCGP 301
             .:|.|
  Fly   594 FFVCLP 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
app	NP_648561.2	zf-DHHC	146..270	CDD:279823	44/142 (31%)
Patsas	NP_001356957.1	ANKYR	113..306	CDD:223738
		ANK repeat	148..181	CDD:293786
		ANK repeat	187..214	CDD:293786
		ANK repeat	216..247	CDD:293786
		ANK repeat	249..280	CDD:293786
		ANK repeat	282..314	CDD:293786
		Ank_4	283..336	CDD:316185
		DHHC	455..567	CDD:334580	45/145 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467554
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22883
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840