DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment app and Zdhhc23

DIOPT Version :9

Sequence 1:	NP_648561.2	Gene:	app / 39399	FlyBaseID:	FBgn0260941	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	NP_001007461.1	Gene:	Zdhhc23 / 332175	MGIID:	2685625	Length:	425	Species:	Mus musculus

Alignment Length:	234	Identity:	64/234 - (27%)
Similarity:	100/234 - (42%)	Gaps:	59/234 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 DPGVIPRASNDEAAYIEKQIEVP-----------------NSLNSPTYRPPPR--TKEVLVKGQT 143
            :||.:   |||::. ...|||.|                 .|||:.|.:...|  ::..|.....
Mouse   185 NPGYL---SNDKSP-SNSQIECPVKKGQEKTKGFPGTDASGSLNNRTLKDDVRGSSRVGLDSPAK 245

  Fly   144 VKLKYCFTCKIFRPPRASHCSLCDNCVDRFDHHCPWVGNCVGKRNYRFFYLFLVSLAFLAVFIFS 208
            ||..:|..|::.||.||.||.:|..||.|.||||.|:.:|||:.|::.|.|.|  ..||...::.
Mouse   246 VKEDWCAKCQLVRPARAWHCRICGICVRRMDHHCVWINSCVGESNHQAFILAL--SIFLLTSVYG 308

  Fly   209 CSVTHLVLLMKKEHEVFNVIKAAP-----FTVIVVFICFFSIW-SVIGLAGFHTY------LTTS 261
            .|:|  :..:.::..:|..:...|     ::..:.|.|   :| |||..||. .|      :..|
Mouse   309 ISLT--LNTICRDRSLFTALFYCPGVYANYSSALSFTC---VWYSVIITAGM-AYIFLIQLINIS 367

  Fly   262 DQTTNEDLKGSFSSKGGPRTQNPYSRGNICLNCCHILCG 300
            ...|..:::.:...|.|.|                :|||
Mouse   368 YNVTEREVQQALRQKTGRR----------------LLCG 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
app	NP_648561.2	zf-DHHC	146..270	CDD:279823	41/135 (30%)
Zdhhc23	NP_001007461.1	DHHC	248..374	CDD:396215	41/133 (31%)
Zdhhc23	NP_001007461.1	Interaction with NOS1. /evidence=ECO:0000250	422..425
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810