DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment app and zdhhc6

DIOPT Version :9

Sequence 1:	NP_648561.2	Gene:	app / 39399	FlyBaseID:	FBgn0260941	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	NP_001191086.1	Gene:	zdhhc6 / 324468	ZFINID:	ZDB-GENE-030131-3189	Length:	412	Species:	Danio rerio

Alignment Length:	239	Identity:	59/239 - (24%)
Similarity:	96/239 - (40%)	Gaps:	74/239 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 HTG-VFYLTCILITGTSAL------FFAFDCPFLADSINPAIPIVGAVL----YFFTMSSLLRTT 95
            |.| :..||.|.:..:.|:      ::..|.  ...|||..:.|...||    ||..|
Zfish    21 HWGPIIALTVIGVCSSMAILDSIIWYWPLDT--TGGSINFIMLINWTVLILYNYFNAM------- 76

  Fly    96 FTDPGVIPRASNDEAAYIEKQIEVPNSLNSPTYRPPPRTKEVLVKGQTVKLKYCFTCKIFRPPRA 160
            |..||.||         :|.:              |.:.::::.      |::|..|:.::.||:
Zfish    77 FVGPGYIP---------LEWK--------------PEKQQDIMY------LQFCRLCQGYKAPRS 112

  Fly   161 SHCSLCDNCVDRFDHHCPWVGNCVGKRNYRFFYLFLVSLAFLAVFIFSCSVTHLVLLMKKEHEVF 225
            .||..|:.||.:.||||||:.||.|..|:.:|..||: ||.|     .|....|:.:|....:::
Zfish   113 HHCRKCNRCVMKMDHHCPWINNCCGHLNHAYFTSFLL-LAPL-----GCIHAALIFIMTMYTQLY 171

  Fly   226 NVI-----------KAA--------PFTVIVVFICFFSIWSVIG 250
            :.|           .||        ||::.......|::...:|
Zfish   172 DRISFGWSSVKIDMSAARHIHHPIMPFSIAAFAATLFALGLALG 215

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
app	NP_648561.2	zf-DHHC	146..270	CDD:279823	36/124 (29%)
zdhhc6	NP_001191086.1	DHHC	95..241	CDD:396215	36/133 (27%)
zdhhc6	NP_001191086.1	Di-lysine motif. /evidence=ECO:0000250\|UniProtKB:Q9H6R6	409..412
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810