DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment app and Zdhhc17

DIOPT Version :9

Sequence 1:	NP_648561.2	Gene:	app / 39399	FlyBaseID:	FBgn0260941	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	NP_766142.2	Gene:	Zdhhc17 / 320150	MGIID:	2445110	Length:	632	Species:	Mus musculus

Alignment Length:	333	Identity:	82/333 - (24%)
Similarity:	140/333 - (42%)	Gaps:	83/333 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 WELFAGRNKFYCDGLLMSAPHTGVF-------YLTCILITGTSALFFAFDCPFLADSINPAIPIV 79
            |......:|.:.|..:.||...|::       |:|..........|.....||||:|:
Mouse   339 WATVQFLSKSFFDHSMHSALPLGIYLATKFWMYVTWFFWFWNDLNFLFIHLPFLANSV------- 396

  Fly    80 GAVLYFFTMSSLLRTTFTDPGVIPRASNDEAAYIEKQIEVPNSLNSPTYRPPPRTKEVLVKGQTV 144
             |:.|.|.     ::..:|||:| :|:.::                       :.|.::...:|.
Mouse   397 -ALFYNFG-----KSWKSDPGII-KATEEQ-----------------------KKKTIVELAETG 431

  Fly   145 KLK---YCFTCKIFRPPRASHCSLCDNCVDRFDHHCPWVGNCVGKRNYRFFYLFLVSLAFLAVF- 205
            .|.   :|.||.|.:|.|:.||.:|:.|:.:|||||||||||||..|:|:|..:|..|.|:..:
Mouse   432 SLDLSIFCSTCLIRKPVRSKHCGVCNRCIAKFDHHCPWVGNCVGAGNHRYFMGYLFFLLFMICWM 496

  Fly   206 IFSCSVTHLVLLMKKEHE-------VFNVIKAAPFTVIVVFI--CFFSIWSVIGLAGFHTYLTTS 261
            |:.| |::..|..:..:.       :..:...:|: :..:|:  .|..:|..:.|......:|..
Mouse   497 IYGC-VSYWGLHCETTYTKDGFWTYITQIATCSPW-MFWMFLNSVFHFLWVAVLLMCQLYQITCL 559

  Fly   262 DQTTNEDL--------KGSFSSKGGPRTQNPYSRG---NIC----LNCCHILCGPMTPSLIDRRG 311
            ..||||.:        |.:.:|     .::|::.|   ||.    ..|    ||...|.::|...
Mouse   560 GITTNERMNARRYKHFKVTTTS-----IESPFNHGCVRNIIDFFEFRC----CGLFRPVIVDWTR 615

  Fly   312 IATDEFIQ 319
            ..|.|:.|
Mouse   616 QYTIEYDQ 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
app	NP_648561.2	zf-DHHC	146..270	CDD:279823	44/144 (31%)
Zdhhc17	NP_766142.2	Necessary and sufficient for interaction with DNAJC5 and SNAP25. /evidence=ECO:0000269\|PubMed:25253725	11..305
		ANK repeat	89..120	CDD:293786
		PHA03095	100..>352	CDD:222980	2/12 (17%)
		ANK repeat	122..154	CDD:293786
		ANK repeat	156..187	CDD:293786
		Ank_2	161..255	CDD:372319
		ANK repeat	189..221	CDD:293786
		ANK repeat	224..255	CDD:293786
		DHHC	438..568	CDD:366691	43/131 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810