Protein Alignment app and Zdhhc8

DIOPT Version :9

• Sequence 1: NP_648561.2
• Gene: app / 39399
• FlyBaseID: FBgn0260941
• Length: 755
• Species: Drosophila melanogaster
• Sequence 2: NP_001259382.1
• Gene: Zdhhc8 / 31887
• FlyBaseID: FBgn0085478
• Length: 1052
• Species: Drosophila melanogaster
• Alignment Length: 782
• Identity: 222/782 - (28%)
• Similarity: 317/782 - (40%)
• Gaps: 196/782 - (25%)

  Fly    33 CDGLLMSAPHTGVFYLTCILITGTSALFFAFDCPFLADSINPAIPIVGAVLYFFTMSSLLRTTFT 97
            ||......|.|    ...|::..|:.|||.:.|.|...| :|.:.....|:.||.:::....||.
  Fly     4 CDVKTRYIPAT----FAWIVLLLTTFLFFFYPCQFYVKS-HPWVLAYQGVITFFVLANFTLATFM 63

  Fly    98 DPGVIPRASNDEAAYIEKQIEVPNSLNSPTYRPPPRTKEVLVKGQTVKLKYCFTCKIFRPPRASH 162
            |||:||:||.||        :....|.:|.|      |...:.|.|||:|:|.|||.:||||.||
  Fly    64 DPGIIPKASPDE--------DCEEELRAPLY------KNAEINGITVKMKWCVTCKFYRPPRCSH 114

  Fly   163 CSLCDNCVDRFDHHCPWVGNCVGKRNYRFFYLFLVSLAFLAVFIFSCSVTHLVLLMKKEHEVFNV 227
            ||:|::|::.||||||||.||:|:||||||:.|||||:...:.|||..:.:::.:|.      |:
  Fly   115 CSVCNHCIETFDHHCPWVNNCIGRRNYRFFFFFLVSLSIHMLSIFSLCLVYVLKIMP------NI 173

  Fly   228 IKAAPFTVIVV--FICFFSIWSVIGLAGFHTYLTTSDQTTNEDLKGSFSSKGGPRTQNPYSRGNI 290
            ...||...|::  .:...:| .:.||.|||..|.:..:||||.:.|.|  |||   .||:|||
  Fly   174 KDTAPIVAIILMGLVTILAI-PIFGLTGFHMVLVSRGRTTNEQVTGKF--KGG---YNPFSRG-- 230

  Fly   291 CL-NCCHILCGPMTPSLIDRRGIATDEFIQQMQHQSSPRHALSDVLS-ASHMVTTSQPMMGGLGG 353
            |. |||:...||..|||::.:..|:..  .|:|:|     |:|.:.: .|...|.:....||.|.
  Fly   231 CWHNCCYTQFGPQYPSLLNPKKYASRR--SQVQNQ-----AISTICNDRSGQQTGAGSGAGGNGT 288

  Fly   354 GGIGGAGGGISIGG------AELKPR-FYDESNPSSSTLEGNGGAINGHGNGHGNGFDHPPPSYD 411
            ..:.|.|||:..||      .:..|| |||.|.      |..|..:..: ...|||::....|..
  Fly   289 AAVSGGGGGVGSGGGMRGTAVQYSPRSFYDASR------EKRGIQVKTY-MAEGNGYNQRSGSTT 346

  Fly   412 LVQNGKSRKHHQQRCSLQTL--LPASAQQQFKASKHKHKQLKQHLVAAELQQHEG-------GPG 467
            |.    |:....:.||...|  .|||..|..:.:....:.........::....|       |.|
  Fly   347 LY----SKLSPGRECSDTDLEPPPASQSQDCEPTPPLQRHNSSSFYLPQVSDSGGLNGSVSTGGG 407

  Fly   468 PGPNSPSLLRSPATSSSYRLNLKRSLHLP------LTP--SYDDVRHSPLPLLHHHV-------- 516
            .|.:||..:|           |....|.|      |.|  .|.....||    .|.|
  Fly   408 GGGDSPRHMR-----------LYHPRHSPHARPRGLDPQRGYTSDALSP----DHPVGYGVGVNG 457

  Fly   517 -HAQQTTAIGTVAAAAAAVASGASGTNTGTGTGTGGSSSSATTTA---------PTSVSVSLATA 571
             ..||..|:...|||||..|.               :..||||||         |..|:..|..|
  Fly   458 SQQQQQQALAAAAAAAAVAAQ---------------NQRSATTTATPTMQQRIKPLGVATPLVMA 507

  Fly   572 PP--------PLAPRRPSTLQLQASGAISASNSTLTTIHTTAPQAPAPTDFKYYS---PQRSTDS 625
            .|        |..||||..:.|.|.........     ...|..|.|...::|.|   ||.
  Fly   508 SPVRRSNPGTPTQPRRPDFIGLNAQAVAQQQQQ-----QQQAAAAAAAAYYEYTSGLPPQH---- 563

  Fly   626 NLMRNYPFPKAARGMRRQSTMSVDSQKVNIAGYQPLPMRKPYKHQEVMFELK------------- 677
                    |:|....::|..:.:..|:|.:...|.....:..:.|:....:.
  Fly   564 --------PQAPSIQQQQQQLLLQQQRVLMQHQQQQQALQQQQQQQQQAAVHAAHPQHAALAQAA 620

  Fly   678 ---SPTNRL-----TIRECDFGG--GGE--------PCDDDQSIKDSQIFRVSKRNLYMNHRSPW 724
               ||..|.     .:|:...||  |||        ..|:.:.:..|     .:|.:||     |
  Fly   621 YGGSPQRRFLSEGELVRQGAGGGVAGGELSYARSNNTVDNIRELAGS-----PQRGVYM-----W 675

  Fly   725 KE 726
            |:
  Fly   676 KD 677

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
app	NP_648561.2	zf-DHHC	146..270	CDD:279823	56/125 (45%)
Zdhhc8	NP_001259382.1	zf-DHHC	94..219	CDD:279823	59/131 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I1540
eggNOG	1	0.900	-	-		E1_COG5273
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1264614at2759
OrthoFinder	1	1.000	-	-		FOG0000285
OrthoInspector	1	1.000	-	-		otm46915
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R405
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.850