DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment app and Zdhhc8

DIOPT Version :9

Sequence 1:	NP_648561.2	Gene:	app / 39399	FlyBaseID:	FBgn0260941	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	XP_006248672.1	Gene:	Zdhhc8 / 303796	RGDID:	1308875	Length:	775	Species:	Rattus norvegicus

Alignment Length:	847	Identity:	216/847 - (25%)
Similarity:	308/847 - (36%)	Gaps:	297/847 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 LITGTSALFFAFDCPFLADSINPAIPIVGAVLYFFTMSSLLRTTFTDPGVIPRASNDEAAYIEKQ 116
            |:.|:|.|||.|.||:|..:::||||:...:|:.|.:::....||.||||.|||..||    :|:
  Rat    23 LLVGSSTLFFVFTCPWLTRAVSPAIPVYNGILFLFVLANFSMATFMDPGVFPRADEDE----DKE 83

  Fly   117 IEVPNSLNSPTYRPPPRTKEVLVKGQTVKLKYCFTCKIFRPPRASHCSLCDNCVDRFDHHCPWVG 181
                :...:|.|      |.|.|:|..|::|:|.||..:||||.||||:|||||:.||||||||.
  Rat    84 ----DDFRAPLY------KNVDVRGIQVRMKWCATCHFYRPPRCSHCSVCDNCVEDFDHHCPWVN 138

  Fly   182 NCVGKRNYRFFYLFLVSLAFLAVFIFSCSVTHLV------LLMKKEHEVFNVIKAAPFTVIVVFI 240
            ||:|:||||:|:|||:||:           .|:|      ||....|.  ..:.||..|:.:..:
  Rat   139 NCIGRRNYRYFFLFLLSLS-----------AHMVGVVAFGLLYVLNHS--EGLGAAHTTITMAVM 190

  Fly   241 CFFSIW--SVIGLAGFHTYLTTSDQTTNEDLKGSFSSKGGPRTQNPYSRGNICL-NCCHILCGPM 302
            |...::  .||||.|||..|.|..:||||.:.|.|  :||   .||::||  |. |..|:||.|:
  Rat   191 CVAGLFFIPVIGLTGFHVVLVTRGRTTNEQVTGKF--RGG---VNPFTRG--CYGNVEHVLCSPL 248

  Fly   303 TPSLIDRRGIATDEFIQQMQHQSSPRHALSDVLS----ASHMVTTSQPMMGGLGGGGIGGAGGGI 363
            .|..:                ..:||..||..|.    ...::..:.|:...|...|: .||...
  Rat   249 APRYV----------------VEAPRMPLSVSLKPPFLRPELLERAVPLKVKLSDNGL-KAGRSK 296

  Fly   364 SIG-------------------------GAELK--------------------PRFYDESNPSSS 383
            |.|                         |.:||                    |..| :..|:.|
  Rat   297 SKGSLDQLDEKPLDLGPPLPPKMEAGTFGRDLKTPRPGSAESALSVQRTSPPTPAMY-KFRPAFS 360

  Fly   384 T------------LEGNGGAINGHGNGHGNGFDHPPPSYDLVQNGKSRKHHQQRCSLQTLLPASA 436
            |            :.|.........:.|...| ...||.||..:|....|.....|    .|.||
  Rat   361 TAPKTPFCGPSEQVPGPDSLTLADDSTHSLDF-VSEPSLDLPDHGPGGLHPTYPPS----PPLSA 420

  Fly   437 QQQFKAS------KHKHKQLKQHLVAAELQQHEGGP----------------------------- 466
            ...|..:      |...::...|:....|:. ||||
  Rat   421 TDAFSGALRSLSLKAASRRGGDHMTLQPLRS-EGGPPTPHRGLFAPHALPNRNGSLSYDSLLNPG 484

  Fly   467 -----------------------GPGPNSPSLLRSPATSSSYRLNLKRSLHLPLTPS---YDDVR 505
                                   .|||:.|.  |.|..|.|..|..:     |..||   ||::.
  Rat   485 SPSGHACPTHPSVGMAGYHSPYLHPGPSDPP--RPPPRSFSPVLGPR-----PREPSPVRYDNLS 542

  Fly   506 HSPLPLLHHH---------VHAQQTTAIGTVAA----------AAAAVASGASGT--------NT 543
            .:.:..:...         :.:|..:..|....          .|:.:..|..|:        :.
  Rat   543 RTIMASIQERKDREERERLLRSQTDSLFGDSGVYDTPSSYSLQQASVLTEGPRGSVLRYGSRDDL 607

  Fly   544 GTGTGTGGSSSSATTTAPTSVSVSLATAPPPLAPRRPSTLQLQASGAISASNSTLTTIHTTAPQA 608
            ..|.|.||:.:.|..|:.:|:|.|::.||      |.|:..|||..|           :..|| .
  Rat   608 VAGPGFGGARNPALQTSLSSLSSSMSRAP------RTSSSSLQADQA-----------NNNAP-G 654

  Fly   609 PAPTDFKYYSPQRSTDSNLMRNYPFPKAARGMRRQSTMSVDSQKVNIAGYQPLPMRKPYKHQEVM 673
            |.|....:.||.|       :..|.|.   |..|..:.|  ..|.....:..||.|:|
  Rat   655 PRPGSGSHRSPAR-------QGLPSPP---GTPRSPSYS--GSKAVAFIHTDLPDRQP------- 700

  Fly   674 FELKSPTNRLTIRECDFGGG------GEPCDDDQSIKDSQIFRVSKRNLYMNH----------RS 722
               .....|..|..|..|.|      |.|                  .|::.|          |:
  Rat   701 ---SLAMQRGRIGSCSRGWGWRGPPRGTP------------------GLHLCHLGHPEDHPPLRA 744

  Fly   723 PW 724
            ||
  Rat   745 PW 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
app	NP_648561.2	zf-DHHC	146..270	CDD:279823	60/131 (46%)
Zdhhc8	XP_006248672.1	zf-DHHC	99..224	CDD:279823	61/137 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1264614at2759
OrthoFinder	1	1.000	-	-		FOG0000285
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820