Protein Alignment app and ZDHHC8

DIOPT Version :10

• Sequence 1: NP_648561.2
• Gene: app / 39399
• FlyBaseID: FBgn0260941
• Length: 755
• Species: Drosophila melanogaster
• Sequence 2: NP_001171953.1
• Gene: ZDHHC8 / 29801
• HGNCID: 18474
• Length: 778
• Species: Homo sapiens
• Alignment Length: 839
• Identity: 213/839 - (25%)
• Similarity: 317/839 - (37%)
• Gaps: 274/839 - (32%)

  Fly    52 LITGTSALFFAFDCPFLADSINPAIPIVGAVLYFFTMSSLLRTTFTDPGVIPRASNDEAAYIEKQ 116
            |:.|:|.|||.|.||:|..:::||:|:...:::.|.:::....||.||||.|||..||    :|:
Human    23 LLVGSSTLFFVFTCPWLTRAVSPAVPVYNGIIFLFVLANFSMATFMDPGVFPRADEDE----DKE 83

  Fly   117 IEVPNSLNSPTYRPPPRTKEVLVKGQTVKLKYCFTCKIFRPPRASHCSLCDNCVDRFDHHCPWVG 181
                :...:|.|      |.|.|:|..|::|:|.||..:||||.||||:|||||:.||||||||.
Human    84 ----DDFRAPLY------KNVDVRGIQVRMKWCATCHFYRPPRCSHCSVCDNCVEDFDHHCPWVN 138

  Fly   182 NCVGKRNYRFFYLFLVSLAFLAVFIFSCSVTHLVLLMKKEHEVFNVIKAAPFTVIVVFICFFSIW 246
            ||:|:||||:|:|||:||:...|.:.:..:.:::     .|.  ..:.||..|:.:..:|...::
Human   139 NCIGRRNYRYFFLFLLSLSAHMVGVVAFGLVYVL-----NHA--EGLGAAHTTITMAVMCVAGLF 196

  Fly   247 --SVIGLAGFHTYLTTSDQTTNEDLKGSFSSKGGPRTQNPYSRGNICLNCCHILCGPMTPSLIDR 309
              .||||.|||..|.|..:||||.:.|.|  :||   .||::|| .|.|..|:||.|:.|..:
Human   197 FIPVIGLTGFHVVLVTRGRTTNEQVTGKF--RGG---VNPFTRG-CCGNVEHVLCSPLAPRYV-- 253

  Fly   310 RGIATDEFIQQMQHQSSPRHALSDVLS----ASHMVTTSQPMMGGLGGGGI-GGAGGGISIG--- 366
                          ...||..|:..|.    ...::..:.|:...|...|: .|.|...|.|
Human   254 --------------VEPPRLPLAVSLKPPFLRPELLDRAAPLKVKLSDNGLKAGLGRSKSKGSLD 304

  Fly   367 ---------GAELKPRFYDESNPSSSTLE------------------------------------ 386
                     |..|.|:.  |:...||.|:
Human   305 RLDEKPLDLGPPLPPKI--EAGTFSSDLQTPRPGSAESALSVQRTSPPTPAMYKFRPAFPTGPKV 367

  Fly   387 ---GNGGAINGH-----GNGHGNGFDH-PPPSYDLVQNGKSRKHHQQRCSLQTLLPASAQQQFKA 442
               |.|..:.|.     |:......|. ..||.||...|....|    .:.....|.||...|..
Human   368 PFCGPGEQVPGPDSLTLGDDSIRSLDFVSEPSLDLPDYGPGGLH----AAYPPSPPLSASDAFSG 428

  Fly   443 S------KHKHKQLKQHLVAAELQQHEGGPGPGPN----SPSLLRSPATSSSY--RLN------- 488
            :      |...::...| ||.:..:.|||| |.|:    :|..|.:...|.||  .||
Human   429 ALRSLSLKASSRRGGDH-VALQPLRSEGGP-PTPHRSIFAPHALPNRNGSLSYDSLLNPGSPGGH 491

  Fly   489 -----------------------------LKRSLH-----LPLTPS---YDDVRHSPLPLLHHH- 515
                                         |.||..     .|..||   ||::..:.:..:...
Human   492 ACPAHPAVGVAGYHSPYLHPGATGDPPRPLPRSFSPVLGPRPREPSPVRYDNLSRTIMASIQERK 556

  Fly   516 --------VHAQQTTAIGTVAA----------AAAAVASGASG--------TNTGTGTGTGGSSS 554
                    :.:|..:..|....          .|:.::.|..|        .:...|.|.||:.:
Human   557 DREERERLLRSQADSLFGDSGVYDAPSSYSLQQASVLSEGPRGPALRYGSRDDLVAGPGFGGARN 621

  Fly   555 SATTTAPTSVSVSLATAPPPLAPRRPSTLQLQASGAISASNSTLTTIHTTAPQAPAPTDFKYYSP 619
            .|..|:.:|:|.|::.||      |.|:..|||..|.|           .|| .|.|:...:.||
Human   622 PALQTSLSSLSSSVSRAP------RTSSSSLQADQASS-----------NAP-GPRPSSGSHRSP 668

  Fly   620 QRSTDSNLMRNYPFPKAARGMRRQSTMSVDSQKVNIAGYQPLPMRKPYKHQEVMFELKSPTNRLT 684
            .|       :..|.|...            ....:.||    |....:.|.    :|..|...||
Human   669 AR-------QGLPSPPGT------------PHSPSYAG----PKAVAFIHT----DLPEPPPSLT 706

  Fly   685 IRE-----CDFGGG--GEPCDDDQSIKDSQIFRVSKRNLYMNH----------RSPWKE 726
            ::.     |..|.|  |:|.              ....|::.|          |:||.:
Human   707 VQRGRIGTCTRGWGRRGQPW--------------VPPGLHLCHLGRPEDRPPLRAPWSQ 751

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
app	NP_648561.2	DHHC	146..270	CDD:396215	57/125 (46%)
ZDHHC8	NP_001171953.1	DHHC	99..224	CDD:396215	58/131 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	293..352		11/60 (18%)
		PHA03247	<333..771	CDD:223021	90/484 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	509..540		6/30 (20%)