DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment app and ZDHHC23

DIOPT Version :9

Sequence 1:	NP_648561.2	Gene:	app / 39399	FlyBaseID:	FBgn0260941	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	NP_001307395.1	Gene:	ZDHHC23 / 254887	HGNCID:	28654	Length:	435	Species:	Homo sapiens

Alignment Length:	299	Identity:	76/299 - (25%)
Similarity:	123/299 - (41%)	Gaps:	71/299 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 PIVGAVL---YFFTMSSLLRTTFTDPGVIPRASNDEAAYIEKQIE-----------------VPN 121
            |:..|||   .|..:.:|.|.. .:||.:...::.:.:....|:|                 :..
Human   168 PVQLAVLTCGLFLILLALHRAK-KNPGYLSNPASGDRSLSSSQLECLSRKGQEKTKGFPGADMSG 231

  Fly   122 SLNSPTYRPPPRTKEVLVKGQTVKLK--YCFTCKIFRPPRASHCSLCDNCVDRFDHHCPWVGNCV 184
            |||:.|.:..|:....:..|...|.|  :|..|::.||.||.||.:|..||.|.||||.|:.:||
Human   232 SLNNRTTKDDPKGSSKMPAGSPTKAKEDWCAKCQLVRPARAWHCRICGICVRRMDHHCVWINSCV 296

  Fly   185 GKRNYRFFYLFLVSLAFLAVFIFSCSVTHLVLLMKKEHEVFNVIKAAP-----FTVIVVFICFFS 244
            |:.|::.|.|.|  |.||...::..::|  :..:.::..||..:...|     ::..:.|.|
Human   297 GESNHQAFILAL--LIFLLTSVYGITLT--LDTICRDRSVFTALFYCPGVYANYSSALSFTC--- 354

  Fly   245 IW-SVIGLAGFHTY------LTTSDQTTNEDLKGSFSSKGGPRTQNPYSRGNICLNCCHILCGPM 302
            :| |||..||. .|      :..|...|..:::.:...|.|.|                :|||
Human   355 VWYSVIITAGM-AYIFLIQLINISYNVTEREVQQALRQKTGRR----------------LLCG-- 400

  Fly   303 TPSLIDRRGIATDEFIQQMQHQSSP------RHALSDVL 335
               ||...|.....|::.. ||.|.      .|...|::
Human   401 ---LIVDTGQYNRGFLRNW-HQFSTLGTRAFHHPAEDIV 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
app	NP_648561.2	zf-DHHC	146..270	CDD:279823	43/137 (31%)
ZDHHC23	NP_001307395.1	MerC	96..>151	CDD:281231
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	215..255		6/39 (15%)
		zf-DHHC	258..384	CDD:279823	42/133 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810