DRSC/TRiP Functional Genomics Resources

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Protein Alignment app and ZDHHC17

DIOPT Version :9

Sequence 1:NP_648561.2 Gene:app / 39399 FlyBaseID:FBgn0260941 Length:755 Species:Drosophila melanogaster
Sequence 2:NP_056151.2 Gene:ZDHHC17 / 23390 HGNCID:18412 Length:632 Species:Homo sapiens


Alignment Length:344 Identity:81/344 - (23%)
Similarity:138/344 - (40%) Gaps:105/344 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 WELFAGRNKFYCDGLLMSAPHTGVF-------YLTCILITGTSALFFAFDCPFLADSINPAIPIV 79
            |......:|.:.|..:.||...|::       |:|..........|.....||||:|:       
Human   339 WATVQFLSKSFFDHSMHSALPLGIYLATKFWMYVTWFFWFWNDLNFLFIHLPFLANSV------- 396

  Fly    80 GAVLYFFTMSSLLRTTFTDPGVIPRASNDEAAYIEKQIEVPNSLNSPTYRPPPRTKEVLVKGQTV 144
             |:.|.|.     ::..:|||:| :|:.::                       :.|.::...:|.
Human   397 -ALFYNFG-----KSWKSDPGII-KATEEQ-----------------------KKKTIVELAETG 431

  Fly   145 KLK---YCFTCKIFRPPRASHCSLCDNCVDRFDHHCPWVGNCVGKRNYRFFYLFLVSLAFLAVF- 205
            .|.   :|.||.|.:|.|:.||.:|:.|:.:|||||||||||||..|:|:|..:|..|.|:..: 
Human   432 SLDLSIFCSTCLIRKPVRSKHCGVCNRCIAKFDHHCPWVGNCVGAGNHRYFMGYLFFLLFMICWM 496

  Fly   206 IFSCSVTHLVLLMKKEHE-------VFNVIKAAPFT-------------VIVVFICFFSIWSVIG 250
            |:.| :::..|..:..:.       :..:...:|:.             |.|:.:|.....|.:|
Human   497 IYGC-ISYWGLHCETTYTKDGFWTYITQIATCSPWMFWMFLNSVFHFMWVAVLLMCQMYQISCLG 560

  Fly   251 LAGFHTYLTTSDQTTNEDL--------KGSFSSKGGPRTQNPYSRG---NIC----LNCCHILCG 300
            :            ||||.:        |.:.:|     .::|::.|   ||.    ..|    ||
Human   561 I------------TTNERMNARRYKHFKVTTTS-----IESPFNHGCVRNIIDFFEFRC----CG 604

  Fly   301 PMTPSLIDRRGIATDEFIQ 319
            ...|.::|.....|.|:.|
Human   605 LFRPVIVDWTRQYTIEYDQ 623

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
appNP_648561.2 zf-DHHC 146..270 CDD:279823 43/155 (28%)
ZDHHC17NP_056151.2 Necessary and sufficient for interaction with DNAJC5 and SNAP25. /evidence=ECO:0000250|UniProtKB:Q80TN5 11..305
ANK repeat 89..120 CDD:293786
Ank_2 94..187 CDD:403870
ANK repeat 122..154 CDD:293786
ANK repeat 156..187 CDD:293786
Ank_2 161..255 CDD:403870
ANK repeat 189..221 CDD:293786
ANK repeat 224..255 CDD:293786
Ank_2 229..>286 CDD:423045
DHHC 438..568 CDD:396215 42/142 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5273
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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