Protein Alignment app and Zdhhc5

DIOPT Version :10

• Sequence 1: NP_648561.2
• Gene: app / 39399
• FlyBaseID: FBgn0260941
• Length: 755
• Species: Drosophila melanogaster
• Sequence 2: NP_659136.1
• Gene: Zdhhc5 / 228136
• MGIID: 1923573
• Length: 715
• Species: Mus musculus
• Alignment Length: 729
• Identity: 190/729 - (26%)
• Similarity: 272/729 - (37%)
• Gaps: 221/729 - (30%)

  Fly    51 ILITGTSALFFAFDCPFLADSINPAIPIVGAVLYFFTMSSLLRTTFTDPGVIPRASNDEAAYIEK 115
            |.:.|.:.|||||.||.|:.:::||:||..|:::.|.:::....||.|||:.|||..||    :|
Mouse    22 IFLVGATTLFFAFTCPGLSLNVSPAVPIYNAIMFLFVLANFSMATFMDPGIFPRAEEDE----DK 82

  Fly   116 QIEVPNSLNSPTYRPPPRTKEVLVKGQTVKLKYCFTCKIFRPPRASHCSLCDNCVDRFDHHCPWV 180
            :    :...:|.|      |.|.:||..|::|:|.||:.:||||.||||:|||||:.||||||||
Mouse    83 E----DDFRAPLY------KTVEIKGIQVRMKWCATCRFYRPPRCSHCSVCDNCVEEFDHHCPWV 137

  Fly   181 GNCVGKRNYRFFYLFLVSLA--FLAVFIFSCSVTHLVLLMKKEHEVFNVIKAAPFTVIVVFICFF 243
            .||:|:||||:|:|||:||.  .:.||.|.     |:.::....|:..|..|....|:.|...||
Mouse   138 NNCIGRRNYRYFFLFLLSLTAHIMGVFGFG-----LLYVLYHIEELSGVRTAVTMAVMCVAGLFF 197

  Fly   244 SIWSVIGLAGFHTYLTTSDQTTNEDLKGSFSSKGGPRTQNPYSRGNICLNCCHILC--------- 299
            .  .|.||.|||..|....:||||.:.|.|  :||   .||::.| .|.|...:||
Mouse   198 I--PVAGLTGFHVVLVARGRTTNEQVTGKF--RGG---VNPFTNG-CCNNVSRVLCSSPAPRYLG 254

  Fly   300 ----------------------------------------------------------------- 299
                                                                             
Mouse   255 RPKKEKTIVIRPPFLRPEVSDGQITVKIMDNGIQGELRRTKSKGSLEITESQSADAEPPPPPKPD 319

  Fly   300 -------------------------GPMTPSLID-RRGIATDEFIQQMQHQSSPRHALSDVL--- 335
                                     .|.||::.. |.|.::......|.|.||.:.:..|.|
Mouse   320 LSRYTGLRTHLSLATNEDSSLLGKDSPPTPTMYKYRPGYSSSSTSAAMPHSSSAKLSRGDSLKEP 384

  Fly   336 -----SASHMVTTSQ--------------------PMMGGLGGGGIGGA-GGGISIGGAELKPRF 374
                 |:.|....|:                    |:..|.....:..| |.|..:|..:   ..
Mouse   385 TSIADSSRHPSYRSEPSLEPESFRSPTFGKSFHFDPLSSGSRSSSLKSAQGTGFELGQLQ---SI 446

  Fly   375 YDESNPSSSTLEGNGGAINGHGNGHGNG---FD-----HPPPSYDLVQNGKSRKHHQQRCSLQTL 431
            ..|...|:|        .....|...||   :|     ...|.::.||.|..........|  ..
Mouse   447 RSEGTTSTS--------YKSLANQTRNGSLSYDSLLTPSDSPDFESVQAGPEPDPPLGYTS--PF 501

  Fly   432 LPASAQQQFKASKH----------------KHKQLKQHLVAAELQQHEGGPGPGPNSPSLLRSPA 480
            |.|...||.:|.:|                ::..|.:|:||: ||:.|......|........|.
Mouse   502 LSARLAQQREAERHPRLLPTGPPHREPSPVRYDNLSRHIVAS-LQEREKLLRQSPPLAGREEEPG 565

  Fly   481 TSSSYRLNLKRSLHLPLT-PSYDDVRHSPLPLLHHHVHAQQTTAIGTVAAAAAAVASGASGTNTG 544
            ...|...:...|.|.|.| .|.||.:.|||          ..|.:|..|........|......|
Mouse   566 LGDSGIQSTPGSGHAPRTSSSSDDSKRSPL----------SKTPLGRPAVPRFGKPDGLRSRGLG 620

  Fly   545 T---GTGT---GGSSSSATTTAPTSVSVSLATAPPPLAPRRPSTLQLQASGAISASNSTLTTIHT 603
            :   ||..   |.|.|.::..||:.||.:...|..||...:.   ::|.....|.||....:|.:
Mouse   621 SPEPGTTAPYLGRSISYSSQKAPSGVSETEEVALQPLLTPKD---EVQLKTTYSKSNGQPKSIGS 682

  Fly   604 TAP---QAP--APT 612
            .:|   |.|  :||
Mouse   683 ASPGPGQPPLSSPT 696

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
app	NP_648561.2	DHHC	146..270	CDD:396215	60/125 (48%)
Zdhhc5	NP_659136.1	DHHC	99..224	CDD:396215	61/131 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	289..715		85/435 (20%)