DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment app and dhhc-14

DIOPT Version :9

Sequence 1:	NP_648561.2	Gene:	app / 39399	FlyBaseID:	FBgn0260941	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	NP_001024514.2	Gene:	dhhc-14 / 181109	WormBaseID:	WBGene00044071	Length:	565	Species:	Caenorhabditis elegans

Alignment Length:	309	Identity:	78/309 - (25%)
Similarity:	127/309 - (41%)	Gaps:	81/309 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 PHTGVF-------YLTCILITGTSALFFAFDCPFLA-----DSINP-------AIPIVGAVLYFF 86
            |..|.|       ||..|:.|.::.:    .|.||.     |..:|       .:.|..|:|...
Worm   276 PMFGFFMTYLLFKYLPLIIATFSTLI----SCIFLMVLIRFDYHDPTYKLLPYGVTIAEAILMVL 336

  Fly    87 TMS-----------------SLLRTTFT-------DPGVIPRASNDEAAYIEKQIEVPNSLNSPT 127
            :.|                 |:|...||       ||||:..|.|....::.:
Worm   337 SWSAYAHWYVPWWAQMLFVLSVLALAFTLFRIGTLDPGVVRAAKNCHQLFVNE------------ 389

  Fly   128 YRPPPRTKEVLVKGQTVKLKYCFTCKIFRPPRASHCSLCDNCVDRFDHHCPWVGNCVGKRNYRFF 192
                   .|..::.|.   ||||||.|.:.....||::|..||:.|||||||:.:||.:||.|.|
Worm   390 -------AEAGIQHQQ---KYCFTCFIRKMDHTKHCAVCGFCVNNFDHHCPWLNSCVTRRNMREF 444

  Fly   193 YLFLVSLAFLAVFIFSCSVTHLVLLMKKEHEVFNVIKAAPFTVIVVFICFFSIWSVIGLAG-FHT 256
            .:|::|:: ::..|:..:.:|..||..::|.:...::...|.:|.:.:   |....:.||. |..
Worm   445 IMFVISVS-VSSAIYCMATSHYALLQIEDHGLEEFLETDAFLMITIIL---SAMHALMLAVLFCV 505

  Fly   257 YLTTSDQ--TTNEDLK----GSFSSKGGPRTQNP-YSRGNICLNCCHIL 298
            .:....|  |||:.:|    |...|..|....|. :.:.:|...|.::|
Worm   506 QMNQISQGVTTNDRIKARRAGHAHSHSGSTDYNVIHHKPSISKRCHNLL 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
app	NP_648561.2	zf-DHHC	146..270	CDD:279823	42/126 (33%)
dhhc-14	NP_001024514.2	ANK	19..143	CDD:238125
		Ank_2	30..120	CDD:289560
		ANK repeat	55..87	CDD:293786
		ANK repeat	89..120	CDD:293786
		Ank_2	94..222	CDD:289560
		ANK	117..244	CDD:238125
		ANK repeat	190..222	CDD:293786
		PulO	<261..>367	CDD:224900	20/94 (21%)
		zf-DHHC	394..521	CDD:279823	43/133 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910