Protein Alignment app and dhhc-8

DIOPT Version :10

• Sequence 1: NP_648561.2
• Gene: app / 39399
• FlyBaseID: FBgn0260941
• Length: 755
• Species: Drosophila melanogaster
• Sequence 2: NP_001407508.1
• Gene: dhhc-8 / 176731
• WormBaseID: WBGene00012718
• Length: 475
• Species: Caenorhabditis elegans
• Alignment Length: 598
• Identity: 152/598 - (25%)
• Similarity: 213/598 - (35%)
• Gaps: 212/598 - (35%)

  Fly    52 LITGTSALFFAFDCPFLADSIN-PAIPIVG--AVLYFFTMSSLLRTTFTDPGVIPRASNDEAAYI 113
            ||.|.|..||.|..|.:.:..: |.:.::.  .||:....|:||.....||.|.|.|...|.
 Worm    17 LIIGCSVSFFWFIAPQIWNQWHTPGLILIAIDVVLFLMVSSNLLMAMLLDPAVHPYAIGSEE--- 78

  Fly   114 EKQIEVPNSLNSPTYRPPPRTKEVLVKGQTVKLKYCFTCKIFRPPRASHCSLCDNCVDRFDHHCP 178
            ..|::   .|.:|.|      |.|.:.|.||::|:|.|||.:||||:||||:|:.|::.||||||
 Worm    79 PTQVD---DLRAPLY------KNVDINGITVRMKWCVTCKFYRPPRSSHCSVCNRCIETFDHHCP 134

  Fly   179 WVGNCVGKRNYRFFYLFLVSLAFLAVFIFSCSVTH-------LVLLMKKEHEVFNVIKAAPF--T 234
            ||.|||||||||:|:.||.||:...:::|.....:       |.....::|     |.:.|:  .
 Worm   135 WVHNCVGKRNYRYFFFFLCSLSIHMMYVFFLCFAYVWSGSFDLRDTNARDH-----ILSPPYLCA 194

  Fly   235 VIVVFICFFSIWSVIGLAGFHTYLTTSDQTTNEDLKGSFSSKGGPRTQNPYSRGNICL-NCCHIL 298
            ::::.:|......||||..||..|....:||||.:.|.|:|     ..||::.|  |. ||...|
 Worm   195 IVLLALCAVLCVPVIGLTVFHLVLVARGRTTNEQVTGKFTS-----GYNPFTIG--CWGNCKKTL 252

  Fly   299 CGPMTPS------------------LIDRRGIATDEFIQQMQHQSSPRHALS------------- 332
            |....|:                  |.:|.....:|   |..|....|...|
 Worm   253 CHSQLPTFKSHVMEFRKQRKEEQARLANRINGPVEE---QNAHADDERDETSVLYVPDQKRADGK 314

  Fly   333 -----------DVLSASHMVTT----------------SQPMMGGLGGGGIGGAGGGISIGGAEL 370
                       .||...:..||                |..|..|.....|...|||   ||||.
 Worm   315 MVAVVEFNKNNSVLRQQNTTTTTSRSESQNRITESQSQSMSMSSGCDESRITVGGGG---GGAEA 376

  Fly   371 KPRFYDESNPSSSTLEGNGGAINGHGNGHGNGFDHPPPSYDLVQNGKSRKHHQQRCSLQTLLPAS 435
                 |.|..:...:|..||.              |.|:..|    :|.:.|.:..
 Worm   377 -----DGSTCNLFEMERGGGT--------------PRPNSSL----RSARVHDETV--------- 409

  Fly   436 AQQQFKASKHKHKQLKQHLVAAELQQHEGGPGPGPNSPSLLRSPATSSSYRLNLKRSLHLPLTPS 500
                                               ::||     ||..||...|:.:||.|.:|
 Worm   410 -----------------------------------DTPS-----ATHQSYEEALEEALHGPASP- 433

  Fly   501 YDDVRHSPLPLLHHHVHAQQTTAIGTVAAAAAAVASGASGTNTGTGTGTGGSSSSATTTAPTSVS 565
                                                  ..|.....:.:|..:.|.|.|:|||.|
 Worm   434 --------------------------------------VTTEDSINSKSGRRTPSRTATSPTSGS 460

  Fly   566 VSLATAPPPLAPR 578
            ..|...||...||
 Worm   461 AILQHLPPRPPPR 473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
app	NP_648561.2	DHHC	146..270	CDD:396215	54/132 (41%)
dhhc-8	NP_001407508.1	DHHC	98..232	CDD:396215	56/138 (41%)