DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment app and ZDHHC15

DIOPT Version :9

Sequence 1:	NP_648561.2	Gene:	app / 39399	FlyBaseID:	FBgn0260941	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	NP_659406.1	Gene:	ZDHHC15 / 158866	HGNCID:	20342	Length:	337	Species:	Homo sapiens

Alignment Length:	302	Identity:	81/302 - (26%)
Similarity:	133/302 - (44%)	Gaps:	68/302 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 RKWELFAGRNKFYCDGLLMSAPHTGVFYLTCILITGTSALFFAFD-CPFLADSINPAIPIVGAVL 83
            |.|::........|..:|...|     .|..:|:...|...:.|: |  |...::||..::..:|
Human     3 RGWKMALSGGLRCCRRVLSWVP-----VLVIVLVVLWSYYAYVFELC--LVTVLSPAEKVIYLIL 60

  Fly    84 Y-----FFTM-------------SSLLRTTFTDPGVIPRASNDEAAYIEKQIEVPNSLNSPTYRP 130
            |     |||.             :.....::||.   .|..|:|...::||:.|..:...|.|
Human    61 YHAIFVFFTWTYWKSIFTLPQQPNQKFHLSYTDK---ERYENEERPEVQKQMLVDMAKKLPVY-- 120

  Fly   131 PPRTKEVLVKGQTVKLKYCFTCKIFRPPRASHCSLCDNCVDRFDHHCPWVGNCVGKRNYRFFYLF 195
             .||....|       ::|..|.:.:|.|..|||:|..||.:.|||||||.||:|..||:||..|
Human   121 -TRTGSGAV-------RFCDRCHLIKPDRCHHCSVCAMCVLKMDHHCPWVNNCIGFSNYKFFLQF 177

  Fly   196 L----VSLAFLAVFIFSCSVTH----LVLLMKKEHEVFNVIKAAPFTVIVVFI-CFFSIWSVIGL 251
            |    :...::|..:||..:.:    |..:..|.|.:|           ::|: |.|.: |::.|
Human   178 LAYSVLYCLYIATTVFSYFIKYWRGELPSVRSKFHVLF-----------LLFVACMFFV-SLVIL 230

  Fly   252 AGFHTYLTTSDQTTNEDLKGSFSS---KGGPRTQNPYSRGNI 290
            .|:|.:|.:.::||.|    :|.:   ..||. :|.::.|.|
Human   231 FGYHCWLVSRNKTTLE----AFCTPVFTSGPE-KNGFNLGFI 267

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
app	NP_648561.2	zf-DHHC	146..270	CDD:279823	44/132 (33%)
ZDHHC15	NP_659406.1	zf-DHHC	<126..308	CDD:327686	51/166 (31%)
ZDHHC15	NP_659406.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	306..337
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810