Protein Alignment app and Zdhhc8

DIOPT Version :10

• Sequence 1: NP_648561.2
• Gene: app / 39399
• FlyBaseID: FBgn0260941
• Length: 755
• Species: Drosophila melanogaster
• Sequence 2: XP_061512661.1
• Gene: Zdhhc8 / 1271656
• VectorBaseID: AGAMI1_012189
• Length: 919
• Species: Anopheles gambiae
• Alignment Length: 818
• Identity: 215/818 - (26%)
• Similarity: 320/818 - (39%)
• Gaps: 224/818 - (27%)

  Fly    33 CDGLLMSAPHTGVFYLTCILITGTSALFFAFDCPFLADSINPAIPIVGAVLYFFTMSSLLRTTFT 97
            ||......|.|  |..|  |:..|:.|||.:.|.......:|.:|...||:.||.:::....||.
Mosquito     4 CDVKTRYIPAT--FAWT--LLLSTTFLFFWYPCRQFYIHRHPWVPAYQAVITFFVIANFTLATFM 64

  Fly    98 DPGVIPRASNDEAAYIEKQIEVPNSLNSPTYRPPPRTKEVLVKGQTVKLKYCFTCKIFRPPRASH 162
            ||||||:|..||        :..:...:|.|      |...:.|.||::|:|.|||.:||||.||
Mosquito    65 DPGVIPKAPPDE--------DREDEFRAPLY------KNAEINGITVRMKWCVTCKFYRPPRCSH 115

  Fly   163 CSLCDNCVDRFDHHCPWVGNCVGKRNYRFFYLFLVSLAFLAVFIFSCSVTHLVLLMKKEHEVFNV 227
            ||:|::|::.||||||||.||:|:||||||:.||:||:...:.|||.|   ||.:::||.:....
Mosquito   116 CSVCNHCIETFDHHCPWVNNCIGRRNYRFFFFFLISLSVHMLSIFSLS---LVYVLQKEKDKLTE 177

  Fly   228 IKAAPFTVIVVFICFFSIWSVIGLAGFHTYLTTSDQTTNEDLKGSFSSKGGPRTQNPYSRGNICL 292
            ::.....:::..:...:| .:.||.|||..|.:..:||||.:.|.|  |||   .||:|||  |.
Mosquito   178 VEPIVAMILMAIVTLLAI-PIFGLTGFHMVLVSRGRTTNEQVTGKF--KGG---YNPFSRG--CW 234

  Fly   293 -NCCHILCGPMTPSLIDRRGIATDEFIQQMQHQSSPRHALSDVLSASHMVTTSQPMMGGLGGGGI 356
             |||:..|||..|||     :...:::.:..::.:  .::|.:.:.           ||.||||.
Mosquito   235 NNCCYTQCGPQYPSL-----LKPQKYVARRSNKEN--QSISTITND-----------GGPGGGGG 281

  Fly   357 GGAGGG---ISIGGAELKPRFYDESNPSSSTLEGNGGAING----------HGNGHG---NGFDH 405
            ..||.|   :..||...:.:...:.....:..:|.|...|.          ||||||   .|..|
Mosquito   282 DAAGSGRRHMPTGGPGSQQQQQQQQQQQQALNQGGGIYDNNRHTQVKTYMDHGNGHGIRTVGSSH 346

  Fly   406 PPPS-YDLV----QNGKSRKHHQQRCSLQTLLP----ASAQQQFKASKHKHKQLKQHLVAAELQQ 461
            ...| .|.|    .:..|.|...|..|...|.|    :....:.:||:.:..:     ....||:
Mosquito   347 YSKSAADYVHLVSSHSVSLKALTQGTSADELSPGRECSDIDMEPQASQSRDCE-----PTPPLQR 406

  Fly   462 HEG----------GP-------GPGPNSPSLLRSPATSSSYRLNLKRSLHLP------------- 496
            |..          ||       |.|.:||   |.........:.:....|.|
Mosquito   407 HGSKSNFFLPPLDGPGGMVSQVGSGGDSP---RQQQQQQQQHMRMYHPRHSPHPRQRGLDPSRSF 468

  Fly   497 ----LTPSYDDVRHSPLPL--LHHHVHAQQTTAIGTVAAAAAAVASGASGTNTGTGTGTGGSSSS 555
                |:|.:......|.|:  :......||....|                        ||..||
Mosquito   469 TPEGLSPDHPGGPGGPPPMITIQSQQQQQQQQPRG------------------------GGPPSS 509

  Fly   556 ATTT-----APTSVSVSLATAPP--------PLAPRRPSTL----------QLQASGAISASNST 597
            ||.|     ....|:..||.:.|        |..||||..:          ||..||.::.:
Mosquito   510 ATPTMQQRIKALGVATPLAMSSPVRRSNPGTPTQPRRPDFISVGQQQQQQQQLGGSGTMTGN--- 571

  Fly   598 LTTIHTTAPQAPAPTDFKYYSPQRSTDSNLMRNYPFPKAARGMRRQSTMSVDSQKVNIAGYQPLP 662
                              ||.              ||  .:..::|....:..|.:.:.....||
Mosquito   572 ------------------YYD--------------FP--LQPQQQQQQQQLPPQSMALHQTTGLP 602

  Fly   663 MRKPY-KHQEVMFELKSPTNRLTIRECDFGG----GGEPCDDDQSIKDSQIFRVSKR--NLYMNH 720
            .:.|| :.|:..:.:....|         ||    ||:| ...|..:..|..|.|..  ::..:|
Mosquito   603 PQHPYHQQQQQQYPMAVHHN---------GGLAGPGGQP-SQQQLQQQQQALRGSNAGPSVVYHH 657

  Fly   721 RSPWK------ERDRYSNLYEYSFNIDLNSIIEDAAGS 752
            .||.:      |..|......|:.|...:..|.:.|||
Mosquito   658 GSPQRRYLSEGELVRQGAELSYARNNQTSDNIRELAGS 695

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
app	NP_648561.2	DHHC	146..270	CDD:396215	55/123 (45%)
Zdhhc8	XP_061512661.1	None