DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment app and zdhhc17

DIOPT Version :9

Sequence 1:	NP_648561.2	Gene:	app / 39399	FlyBaseID:	FBgn0260941	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	NP_001121854.1	Gene:	zdhhc17 / 100148543	ZFINID:	ZDB-GENE-070424-194	Length:	620	Species:	Danio rerio

Alignment Length:	344	Identity:	83/344 - (24%)
Similarity:	138/344 - (40%)	Gaps:	105/344 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 WELFAGRNKFYCDGLLMSAPHTGVF-------YLTCILITGTSALFFAFDCPFLADSINPAIPIV 79
            |.:....:|.:.|..:.||...|::       |:|..........|.....|||.:|:
Zfish   327 WLVVQFLSKSFFDHSMHSALPLGIYLATKFWMYITWFYWFWNDLPFVTIHLPFLLNSL------- 384

  Fly    80 GAVLYFFTMSSLLRTTFTDPGVIPRASNDEAAYIEKQIEVPNSLNSPTYRPPPRTKEVLVKGQTV 144
             |:.|.|.     ::..:|||:| :||.::                       :.|.::...:|.
Zfish   385 -ALFYNFG-----KSWKSDPGII-KASEEQ-----------------------KKKTIVELAETG 419

  Fly   145 KLK---YCFTCKIFRPPRASHCSLCDNCVDRFDHHCPWVGNCVGKRNYRFF--YLFLVSLAFLAV 204
            .|.   :|.||.|.:|.|:.||::|:.|:.:|||||||||||||..|:|:|  |||.: |..:..
Zfish   420 SLDLSIFCSTCLIRKPIRSKHCAVCNRCIAKFDHHCPWVGNCVGSGNHRYFMGYLFFL-LCMICW 483

  Fly   205 FIFSCSV---THLVLLMKKEH---EVFNVIKAAPFT-------------VIVVFICFFSIWSVIG 250
            .::.|..   .|......|:.   .:..:...:|:.             |.|:.:|.....:|:|
Zfish   484 MMYGCICYWRIHCATSYTKDGFWIYITQIATCSPWMFWMFLNSVFHFMWVAVLIMCQLYQIAVLG 548

  Fly   251 LAGFHTYLTTSDQTTNEDL--------KGSFSSKGGPRTQNPYSRG---NIC----LNCCHILCG 300
            :            ||||.:        |.:.:|     .::|::.|   |:.    |.|    ||
Zfish   549 I------------TTNERMNARRYKHFKVTATS-----IESPFNHGCMRNLIDFFELRC----CG 592

  Fly   301 PMTPSLIDRRGIATDEFIQ 319
            .:.|..||.....|.|:.|
Zfish   593 LLRPVPIDWTSQYTIEYDQ 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
app	NP_648561.2	zf-DHHC	146..270	CDD:279823	44/155 (28%)
zdhhc17	NP_001121854.1	PHA02874	<59..>253	CDD:165205
		ANK repeat	77..108	CDD:293786
		ANK 1. /evidence=ECO:0000255	77..106
		ANK repeat	110..142	CDD:293786
		ANK 2. /evidence=ECO:0000255	111..140
		ANK repeat	144..175	CDD:293786
		ANK 3. /evidence=ECO:0000255	144..173
		Ank_2	150..243	CDD:403870
		ANK repeat	177..209	CDD:293786
		ANK 4. /evidence=ECO:0000255	177..207
		ANK repeat	212..243	CDD:293786
		ANK 5. /evidence=ECO:0000255	212..241
		ANK 6. /evidence=ECO:0000255	245..274
		DHHC	426..556	CDD:396215	43/142 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810