Protein Alignment Ak1 and AK5

DIOPT Version :10

• Sequence 1: NP_729792.1
• Gene: Ak1 / 39396
• FlyBaseID: FBgn0022709
• Length: 229
• Species: Drosophila melanogaster
• Sequence 2: NP_777283.1
• Gene: AK5 / 26289
• HGNCID: 365
• Length: 562
• Species: Homo sapiens
• Alignment Length: 199
• Identity: 90/199 - (45%)
• Similarity: 128/199 - (64%)
• Gaps: 10/199 - (5%)

  Fly    21 EELRRARAAADIPIIWILGGPGCGKGTQCAKIVEKYGFTHLSSGDLLRNEVASGSDKGRQLQAVM 85
            |:||:.:      ||:|:||||.||||||.|:||||||||||:|:|||.|:||.|::.:.::.:|
Human   371 EDLRKCK------IIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIM 429

  Fly    86 ASGGLVSNDEVLSLLNDAITRAKGSSKGFLIDGYPRQKNQGIEFEARIAPADLALYFECSEDTMV 150
            ..|.||.:..||.||.:|:..:.|.::|||||||||:..||.||..||....|.:..:||.|||.
Human   430 ERGDLVPSGIVLELLKEAMVASLGDTRGFLIDGYPREVKQGEEFGRRIGDPQLVICMDCSADTMT 494

  Fly   151 QRIMARAAASAVKRDDDNEKTIRARLLTFKQNTNAILELYEPKTL--TINAERDVDDIFLEVVQA 213
            .|::.|:.:|...  ||..|||..||..:.:.:..::..||.||.  .||||...:|:||::..|
Human   495 NRLLQRSRSSLPV--DDTTKTIAKRLEAYYRASIPVIAYYETKTQLHKINAEGTPEDVFLQLCTA 557

  Fly   214 IDCV 217
            ||.:
Human   558 IDSI 561

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ak1	NP_729792.1	aden_kin_iso1	30..217	CDD:130427	87/188 (46%)
AK5	NP_777283.1	DD_AK5	3..46	CDD:438547
		Adenylate kinase 1. /evidence=ECO:0000305|PubMed:19647735	133..316
		ADK	134..307	CDD:238713
		NMP 1. /evidence=ECO:0000250|UniProtKB:P00568	162..193
		LID 1. /evidence=ECO:0000250|UniProtKB:P00568	256..266
		aden_kin_iso1	374..561	CDD:130427	88/194 (45%)
		Adenylate kinase 2. /evidence=ECO:0000305|PubMed:19647735	377..559		85/189 (45%)
		NMP 2. /evidence=ECO:0000269|Ref.9	406..435		11/28 (39%)
		LID 2. /evidence=ECO:0000269|Ref.9	499..509		2/11 (18%)