DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Adk1 and AK5

DIOPT Version :9

Sequence 1:	NP_729792.1	Gene:	Adk1 / 39396	FlyBaseID:	FBgn0022709	Length:	229	Species:	Drosophila melanogaster
Sequence 2:	NP_777283.1	Gene:	AK5 / 26289	HGNCID:	365	Length:	562	Species:	Homo sapiens

Alignment Length:	199	Identity:	90/199 - (45%)
Similarity:	128/199 - (64%)	Gaps:	10/199 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 EELRRARAAADIPIIWILGGPGCGKGTQCAKIVEKYGFTHLSSGDLLRNEVASGSDKGRQLQAVM 85
            |:||:.:      ||:|:||||.||||||.|:||||||||||:|:|||.|:||.|::.:.::.:|
Human   371 EDLRKCK------IIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIM 429

  Fly    86 ASGGLVSNDEVLSLLNDAITRAKGSSKGFLIDGYPRQKNQGIEFEARIAPADLALYFECSEDTMV 150
            ..|.||.:..||.||.:|:..:.|.::|||||||||:..||.||..||....|.:..:||.|||.
Human   430 ERGDLVPSGIVLELLKEAMVASLGDTRGFLIDGYPREVKQGEEFGRRIGDPQLVICMDCSADTMT 494

  Fly   151 QRIMARAAASAVKRDDDNEKTIRARLLTFKQNTNAILELYEPKTL--TINAERDVDDIFLEVVQA 213
            .|::.|:.:|...  ||..|||..||..:.:.:..::..||.||.  .||||...:|:||::..|
Human   495 NRLLQRSRSSLPV--DDTTKTIAKRLEAYYRASIPVIAYYETKTQLHKINAEGTPEDVFLQLCTA 557

  Fly   214 IDCV 217
            ||.:
Human   558 IDSI 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adk1	NP_729792.1	aden_kin_iso1	30..217	CDD:130427	87/188 (46%)
Adk1	NP_729792.1	ADK	34..206	CDD:238713	81/173 (47%)
AK5	NP_777283.1	aden_kin_iso1	133..316	CDD:130427
		Adenylate kinase 1. /evidence=ECO:0000305\|PubMed:19647735	133..316
		ADK	134..307	CDD:238713
		NMP 1. /evidence=ECO:0000250\|UniProtKB:P00568	162..193
		LID 1. /evidence=ECO:0000250\|UniProtKB:P00568	256..266
		aden_kin_iso1	374..561	CDD:130427	88/194 (45%)
		Adenylate kinase 2. /evidence=ECO:0000305\|PubMed:19647735	377..559		85/189 (45%)
		ADK	378..550	CDD:238713	81/173 (47%)
		NMP 2. /evidence=ECO:0000269\|Ref.9	406..435		11/28 (39%)
		LID 2. /evidence=ECO:0000269\|Ref.9	499..509		2/11 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	163	1.000	Domainoid score	I3970
eggNOG	1	0.900	-	-		E1_COG0563
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1378291at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41526
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820