DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Adk1 and AK1

DIOPT Version :9

Sequence 1:	NP_729792.1	Gene:	Adk1 / 39396	FlyBaseID:	FBgn0022709	Length:	229	Species:	Drosophila melanogaster
Sequence 2:	NP_001305051.1	Gene:	AK1 / 203	HGNCID:	361	Length:	210	Species:	Homo sapiens

Alignment Length:	206	Identity:	96/206 - (46%)
Similarity:	136/206 - (66%)	Gaps:	11/206 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 EEKLKA-EELRRARAAADIPIIWILGGPGCGKGTQCAKIVEKYGFTHLSSGDLLRNEVASGSDKG 78
            |:.|:| |:|::.:      ||:::||||.||||||.|||:|||:||||:|||||:||:|||.:|
Human    12 EDDLRAREKLKKTK------IIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRSEVSSGSARG 70

  Fly    79 RQLQAVMASGGLVSNDEVLSLLNDAITRAKGSSKGFLIDGYPRQKNQGIEFEARIAPADLALYFE 143
            ::|..:|..|.||..:.||.:|.||:.....:|||||||||||:..||.|||.||....|.||.:
Human    71 KKLSEIMEKGQLVPLETVLDMLRDAMVAKVNTSKGFLIDGYPREVQQGEEFERRIGQPTLLLYVD 135

  Fly   144 CSEDTMVQRIMARAAASAVKRDDDNEKTIRARLLTFKQNTNAILELYEPKTLT--INAERDVDDI 206
            ...:||.||::.|...|.  |.||||:||:.||.|:.:.|..::..||.:.:.  :|||..||.:
Human   136 AGPETMTQRLLKRGETSG--RVDDNEETIKKRLETYYKATEPVIAFYEKRGIVRKVNAEGSVDSV 198

  Fly   207 FLEVVQAIDCV 217
            |.:|...:|.:
Human   199 FSQVCTHLDAL 209

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adk1	NP_729792.1	aden_kin_iso1	30..217	CDD:130427	91/188 (48%)
Adk1	NP_729792.1	ADK	34..206	CDD:238713	88/173 (51%)
AK1	NP_001305051.1	aden_kin_iso1	22..209	CDD:130427	91/194 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	163	1.000	Domainoid score	I3970
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20135
Inparanoid	1	1.050	179	1.000	Inparanoid score	I4024
Isobase	1	0.950	-	0	Normalized mean entropy	S697
OMA	1	1.010	-	-		QHG54223
OrthoDB	1	1.010	-	-		D1378291at2759
OrthoFinder	1	1.000	-	-		FOG0005806
OrthoInspector	1	1.000	-	-		otm41526
orthoMCL	1	0.900	-	-		OOG6_100591
Panther	1	1.100	-	-	LDO	PTHR23359
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2590
SonicParanoid	1	1.000	-	-		X4196
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.960