DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Adk1 and AK8

DIOPT Version :9

Sequence 1:	NP_729792.1	Gene:	Adk1 / 39396	FlyBaseID:	FBgn0022709	Length:	229	Species:	Drosophila melanogaster
Sequence 2:	XP_005272226.1	Gene:	AK8 / 158067	HGNCID:	26526	Length:	491	Species:	Homo sapiens

Alignment Length:	214	Identity:	47/214 - (21%)
Similarity:	88/214 - (41%)	Gaps:	30/214 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 PIIWILGGPGCGKGTQCAKIVEKYGFTHLSSGDLLRNEVASGSDKGRQLQAVMASGGLVSNDEVL 97
            |.:.:||..|.||..|.|.:.:||...::..|.||:..||..:..|..:|........|.:..::
Human   281 PRVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLM 345

  Fly    98 SLLNDAITRAKGSSKGFLIDGYPRQKNQ-----------------GIEFEA--------RIAPAD 137
            .:|:..:.:.....||:::.|.||..:|                 .:.|::        ||.|..
Human   346 KVLSQRLDQQDCIQKGWVLHGVPRDLDQAHLLNRLGYNPNRVFFLNVPFDSIMERLTLRRIDPVT 410

  Fly   138 LALYFECSEDTMVQRIMARAAASAVKRDDDNEKTIRARLLTFKQNTNAILELYEPKTLTINAERD 202
            ...|....:......|.||    .::...|.|:.::.::..|.:|:..:.:|| ...:|:|.::|
Human   411 GERYHLMYKPPPTMEIQAR----LLQNPKDAEEQVKLKMDLFYRNSADLEQLY-GSAITLNGDQD 470

  Fly   203 VDDIFLEVVQAIDCVLKKK 221
            ...:|..:...|...|.||
Human   471 PYTVFEYIESGIINPLPKK 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adk1	NP_729792.1	aden_kin_iso1	30..217	CDD:130427	44/208 (21%)
Adk1	NP_729792.1	ADK	34..206	CDD:238713	41/196 (21%)
AK8	XP_005272226.1	adk	71..270	CDD:273569
		ADK	71..261	CDD:238713
		adk	282..480	CDD:273569	42/202 (21%)
		ADK	282..474	CDD:238713	41/196 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0563
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810