DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment thoc6 and DWA1

DIOPT Version :9

Sequence 1:	NP_001261750.1	Gene:	thoc6 / 39394	FlyBaseID:	FBgn0036263	Length:	350	Species:	Drosophila melanogaster
Sequence 2:	NP_849989.1	Gene:	DWA1 / 816462	AraportID:	AT2G19430	Length:	367	Species:	Arabidopsis thaliana

Alignment Length:	336	Identity:	85/336 - (25%)
Similarity:	152/336 - (45%)	Gaps:	72/336 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 NNVLAQAISGSKQYLFAGNLFG-----DIFVLRIKELDKGSEEPPGKLKIFPQGSDVDINYLAFH 70
            |::::|:.|           ||     |:.|...:.:.:..|.|...:|.:  |.|.|...|:
plant    60 NSLVSQSAS-----------FGYSKGQDVMVAEPERVVRAHEGPAYDVKFY--GEDEDALLLS-- 109

  Fly    71 RDFLIVGAVGLIYGLEWNEEEESLAT-------------------KRSWEVKIPMQVDAVEVPDV 116
                 .|..|.:.|.:|.|..||..:                   |..|....||       |::
plant   110 -----CGDDGRVRGWKWREFAESDVSLHLKENHLKPLLELINPQHKGPWGALSPM-------PEI 162

  Fly   117 NSMWLDSENSILFAGCGDGVIYQVSLEDGRIQREYRGHTDYVHSVVGNAN-GQIFSGAEDGTVRV 180
            |:|.:|.::..:|...||...|...:|.|:|:..::||:||:|:||..:: .||.:|:||||.|:
plant   163 NAMSVDPQSGSVFTAAGDSCAYCWDVESGKIKMTFKGHSDYLHTVVSRSSASQILTGSEDGTARI 227

  Fly   181 WSTKQQQHTSMLEPYKNPNLLRPDWGKWIGAVAV--NEDWLLCGGGPKASIFHLRSMESTCVFSF 243
            |..|..:...::......:.||      :.::|:  :|.||:||.|...::::|.:.|  ||.:.
plant   228 WDCKTGKCVKVIGSQDKKSRLR------VSSMALDGSESWLVCGQGKNLALWNLPASE--CVQTI 284

  Fly   244 PGRVHLCD--FVDDCVLIGGEHNHVQSYTLNGVLQANIPVEHTA-CYSAVWQTS--PIKFISIAG 303
            |...|:.|  |.:..:|..|....::.:.|||.|.:.|   |.| |  :|:..|  |...:::.|
plant   285 PIPAHVQDVMFDEKQILTVGAEPLLRRFDLNGALLSQI---HCAPC--SVFSISLHPAGVVAVGG 344

  Fly   304 FSNKLHILKDF 314
            :...:.::..|
plant   345 YGGIVDVISQF 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
thoc6	NP_001261750.1	WD40	<45..325	CDD:225201	78/297 (26%)
		WD40	<115..265	CDD:295369	46/154 (30%)
		WD40 repeat	159..194	CDD:293791	13/35 (37%)
		WD40 repeat	209..244	CDD:293791	11/36 (31%)
		WD40 repeat	249..280	CDD:293791	8/32 (25%)
		WD40 repeat	286..320	CDD:293791	6/31 (19%)
DWA1	NP_849989.1	WD40 repeat	26..88	CDD:293791	7/38 (18%)
		WD40	40..306	CDD:421866	72/280 (26%)
		WD40 repeat	163..199	CDD:293791	10/35 (29%)
		WD40 repeat	204..240	CDD:293791	13/35 (37%)
		WD40 repeat	251..285	CDD:293791	11/35 (31%)
		WD40 repeat	292..321	CDD:293791	8/28 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0649
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	100	1.000	Inparanoid score	I2182
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D760323at2759
OrthoFinder	1	1.000	-	-		FOG0007004
OrthoInspector	1	1.000	-	-		oto4027
orthoMCL	1	0.900	-	-		OOG6_106439
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.730