Protein Alignment thoc6 and THOC6

DIOPT Version :10

• Sequence 1: NP_648557.1
• Gene: thoc6 / 39394
• FlyBaseID: FBgn0036263
• Length: 350
• Species: Drosophila melanogaster
• Sequence 2: NP_077315.2
• Gene: THOC6 / 79228
• HGNCID: 28369
• Length: 341
• Species: Homo sapiens
• Alignment Length: 318
• Identity: 92/318 - (28%)
• Similarity: 157/318 - (49%)
• Gaps: 10/318 - (3%)

  Fly     6 LKRAYNNVLAQAISGSKQYLFAGNLFGDIFVLRIKE-LDKGSEEPPGKLKIFPQGSDVDINYLAF 69
            |:|.:..:.:|::|...::|.|||.:|.|.:..:.. |...::|...|..:..|..|..:..:..
Human    20 LQRLHMTIFSQSVSPCGKFLAAGNNYGQIAIFSLSSALSSEAKEESKKPVVTFQAHDGPVYSMVS 84

  Fly    70 HRDFLIVGAVGLIYGLEWNEEEESLATKRSWEVKIPMQVDAVEVPDVNSMWL-DSENSILFAGCG 133
            ....|:....|.:....|.|..:. ..|..|..:.|.:. ::|||::|::.| ..|||::.|| |
Human    85 TDRHLLSAGDGEVKAWLWAEMLKK-GCKELWRRQPPYRT-SLEVPEINALLLVPKENSLILAG-G 146

  Fly   134 DGVIYQVSLEDGRIQREYRGHTDYVHSV-VGNANGQIFSGAEDGTVRVWSTKQQQHTSMLEPYKN 197
            |..::.:.||.|...|..||||||:|.: :...:.::.||.|||.||:|..:..:....:|.||:
Human   147 DCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLRTAKEVQTIEVYKH 211

  Fly   198 PNLLRPDWGKWIGAVAVNEDWLLCGGGPKASIFHLRSMESTCVFSFPGRVHLCDFVDDCVLIGGE 262
            ....||..|:|||.:|.:.||::|||||..:::||||...|.:|..........|..|.:|..|:
Human   212 EECSRPHNGRWIGCLATDSDWMVCGGGPALTLWHLRSSTPTTIFPIRAPQKHVTFYQDLILSAGQ 276

  Fly   263 HNHVQSYTLNGVLQANIPVEHTACYSAVWQTSP----IKFISIAGFSNKLHILKDFRF 316
            ...|..:.|:|.|:|.:|.......|......|    .|.::.||.|.::.:..:..:
Human   277 GRCVNQWQLSGELKAQVPGSSPGLLSLSLNQQPAAPECKVLTAAGNSCRVDVFTNLGY 334

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
thoc6	NP_648557.1	WD40	<11..184	CDD:441893	51/175 (29%)
		WD40	<115..265	CDD:475233	55/151 (36%)
		WD40 repeat	159..194	CDD:293791	9/35 (26%)
		WD40 repeat	209..244	CDD:293791	16/34 (47%)
		WD40 repeat	249..280	CDD:293791	9/30 (30%)
		WD40 repeat	286..320	CDD:293791	6/35 (17%)
THOC6	NP_077315.2	WD 1. /evidence=ECO:0007744|PDB:7APK	22..61		10/38 (26%)
		WD40 repeat	28..74	CDD:293791	11/45 (24%)
		WD40	<31..287	CDD:441893	79/258 (31%)
		WD 2. /evidence=ECO:0007744|PDB:7APK	74..112		5/38 (13%)
		WD40 repeat	79..115	CDD:293791	5/36 (14%)
		WD 3. /evidence=ECO:0007744|PDB:7APK	124..165		16/41 (39%)
		WD40 repeat	130..165	CDD:293791	13/35 (37%)
		WD 4. /evidence=ECO:0007744|PDB:7APK	166..205		14/38 (37%)
		WD40 repeat	171..210	CDD:293791	10/38 (26%)
		WD 5. /evidence=ECO:0007744|PDB:7APK	215..254		19/38 (50%)
		WD 6. /evidence=ECO:0007744|PDB:7APK	256..293		9/36 (25%)
		WD40 repeat	257..285	CDD:293791	5/27 (19%)
		WD 7. /evidence=ECO:0007744|PDB:7APK	295..339		6/40 (15%)