DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment thoc6 and TLE2

DIOPT Version :9

Sequence 1:	NP_001261750.1	Gene:	thoc6 / 39394	FlyBaseID:	FBgn0036263	Length:	350	Species:	Drosophila melanogaster
Sequence 2:	NP_001287775.1	Gene:	TLE2 / 7089	HGNCID:	11838	Length:	744	Species:	Homo sapiens

Alignment Length:	261	Identity:	59/261 - (22%)
Similarity:	100/261 - (38%)	Gaps:	75/261 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 VLAQAISGSKQYLFAGNLFGDIFVLRIKELDKGSEEPPGKL------------KIFPQGSDVDIN 65
            |.|..||||.|:::.|.. |.:.|..:.:  .|::.|..:|            |:.|.|..
Human   461 VCAVTISGSTQHVYTGGK-GCVKVWDVGQ--PGAKTPVAQLDCLNRDNYIRSCKLLPDGRS---- 518

  Fly    66 YLAFHRDFLIVGAVGLIYGLEWNEEEESLATKRSWEVKIPMQVDAVEV----PDVNSMWLDSENS 126
                    ||||.              ..:|...|::..|......|:    |...::.:..:..
Human   519 --------LIVGG--------------EASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAK 561

  Fly   127 ILFAGCGDGVIYQVSLEDGRIQREYRGHTDYVHSV-VGNANGQIFSGAEDGTVRVWSTKQ----Q 186
            :.|:.|.||.|....|::..:.|:::||||....: :.:...::::|..|.|||.|..::    |
Human   562 VCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQ 626

  Fly   187 QHTSMLEPYKNPNLLRPDWGKWIGAV--AVNEDWLLCG-GGPKASIFHLRSME-------STCVF 241
            ||               |:...|.::  ..|:|||..| ......|.|:|..|       .:||.
Human   627 QH---------------DFSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEKYQLHLHESCVL 676

  Fly   242 S 242
            |
Human   677 S 677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
thoc6	NP_001261750.1	WD40	<45..325	CDD:225201	49/229 (21%)
		WD40	<115..265	CDD:295369	34/143 (24%)
		WD40 repeat	159..194	CDD:293791	9/39 (23%)
		WD40 repeat	209..244	CDD:293791	13/44 (30%)
		WD40 repeat	249..280	CDD:293791
		WD40 repeat	286..320	CDD:293791
TLE2	NP_001287775.1	TLE_N	1..128	CDD:281857
		GP domain. /evidence=ECO:0000250\|UniProtKB:Q04724	129..192
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	180..233
		CcN domain. /evidence=ECO:0000250\|UniProtKB:Q04724	193..255
		Nuclear localization signal. /evidence=ECO:0000255	215..218
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	240..259
		SP domain. /evidence=ECO:0000250\|UniProtKB:Q04724	256..424
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..323
		WD40	<456..742	CDD:225201	59/261 (23%)
		WD 1	456..494		11/35 (31%)
		WD40	457..741	CDD:295369	59/261 (23%)
		WD40 repeat	461..500	CDD:293791	13/41 (32%)
		WD 2	502..541		10/64 (16%)
		WD40 repeat	508..546	CDD:293791	11/63 (17%)
		WD 3	546..585		7/38 (18%)
		WD40 repeat	551..587	CDD:293791	7/35 (20%)
		WD 4	588..627		10/38 (26%)
		WD40 repeat	594..629	CDD:293791	9/49 (18%)
		WD40 repeat	634..667	CDD:293791	10/32 (31%)
		WD 5	670..709		3/8 (38%)
		WD40 repeat	675..709	CDD:293791	2/3 (67%)
		WD 6	711..743
		WD40 repeat	716..740	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910