DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment thoc6 and thoc6

DIOPT Version :9

Sequence 1:	NP_001261750.1	Gene:	thoc6 / 39394	FlyBaseID:	FBgn0036263	Length:	350	Species:	Drosophila melanogaster
Sequence 2:	XP_031749611.1	Gene:	thoc6 / 100498236	XenbaseID:	XB-GENE-1010273	Length:	333	Species:	Xenopus tropicalis

Alignment Length:	325	Identity:	104/325 - (32%)
Similarity:	162/325 - (49%)	Gaps:	22/325 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KDLKRAYNNVLAQAISGSKQYLFAGNLFGDIFVLRI--------KELDKGSEEPPGKLKIFPQGS 60
            :.|:..:..|.:|..|...:||.|||..|.|.|..:        |||   |::|   :.||...|
Frog    11 RSLELLHMTVFSQCFSPCGKYLVAGNNLGQIGVFSLSAALSSEAKEL---SKQP---VAIFQAHS 69

  Fly    61 DVDINYLAFHRDFLIVGAVGLIYGLEWNEEEESLATKRSWEVKIPMQVDAVEVPDVNSMWL-DSE 124
            ....:.::..|..:..|. ..:.|..||:.::...| :.|...||.:.: :|.|::|||.| :.:
Frog    70 GPIYSLISTERHLISSGG-NEVKGWNWNDIQKKGCT-QLWTRCIPSRSN-LESPEINSMILNEKD 131

  Fly   125 NSILFAGCGDGVIYQVSLEDGRIQREYRGHTDYVHSV-VGNANGQIFSGAEDGTVRVWSTKQQQH 188
            ||:|.|| |...|:.:.||.|.......||.||:|.: :.....:..||.||||||:|..:....
Frog   132 NSLLLAG-GTCNIHSMDLESGTFTMALEGHEDYIHCLALREQQRECVSGGEDGTVRIWDLRNGAQ 195

  Fly   189 TSMLEPYKNPNLLRPDWGKWIGAVAVNEDWLLCGGGPKASIFHLRSMESTCVFSFPGRVHLCDFV 253
            |..:|.||.....||.:||||..:..:.||::||||||.|::||||:..|.:|..........|.
Frog   196 THKIEVYKYEECARPQYGKWISCLTTDSDWMVCGGGPKLSLWHLRSVTPTTIFPLNESQQQVMFY 260

  Fly   254 DDCVLIGGEHNHVQSYTLNGVLQANIPVEHTACYS-AVWQTS-PIKFISIAGFSNKLHILKDFRF 316
            .|.:|..|:..:|....:||.::|.||......|| :|.:.| ..|.::.||...|:.:..:||:
Frog   261 QDMILCAGQGPYVNHCQINGDIKAQIPSTPRCVYSLSVNEASQENKVLTAAGSGPKIDVFTNFRY 325

Fly 317 316
Frog 326 325

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
thoc6	NP_001261750.1	WD40	<45..325	CDD:225201	89/276 (32%)
		WD40	<115..265	CDD:295369	57/151 (38%)
		WD40 repeat	159..194	CDD:293791	11/35 (31%)
		WD40 repeat	209..244	CDD:293791	16/34 (47%)
		WD40 repeat	249..280	CDD:293791	8/30 (27%)
		WD40 repeat	286..320	CDD:293791	10/33 (30%)
thoc6	XP_031749611.1	WD40 repeat	21..67	CDD:293791	17/53 (32%)
		WD40	<25..268	CDD:421866	84/252 (33%)
		WD40 repeat	72..118	CDD:293791	9/45 (20%)
		WD40 repeat	123..158	CDD:293791	14/35 (40%)
		WD40 repeat	164..203	CDD:293791	13/39 (33%)
		WD40 repeat	211..249	CDD:293791	18/37 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	86	1.000	Domainoid score	I7997
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H11533
Inparanoid	1	1.050	152	1.000	Inparanoid score	I4242
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D447320at33208
OrthoFinder	1	1.000	-	-		FOG0007004
OrthoInspector	1	1.000	-	-		oto102346
Panther	1	1.100	-	-	LDO	PTHR44411
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4782
SonicParanoid	1	1.000	-	-		X5889
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.190