DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Est-P and CES2

DIOPT Version :9

Sequence 1:	NP_788501.1	Gene:	Est-P / 39393	FlyBaseID:	FBgn0000594	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_001352334.1	Gene:	CES2 / 8824	HGNCID:	1864	Length:	559	Species:	Homo sapiens

Alignment Length:	506	Identity:	144/506 - (28%)
Similarity:	223/506 - (44%)	Gaps:	91/506 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 IRGKDNGLYYSYESIPNAEHPTGALRFEAPQPYSHHWTDVFNATQSPVECMQ-----WNQFINEN 93
            ::|.:.|: .::..||.|:.|.|.|||..|:| ...|:.|.:.|..|..|:|     .::|:::.
Human    48 VKGANAGV-QTFLGIPFAKPPLGPLRFAPPEP-PESWSGVRDGTTHPAMCLQDLTAVESEFLSQF 110

  Fly    94 NKLMG----DEDCLTVSIYKPKKPNR-SSFPVVVLLHGGAFMFGSGSIYGHDSIMREGTLLVVKI 153
            |....    .||||.:|||.|...:. |:.||:|.:||||.:||..|:|....:.....::||.|
Human   111 NMTFPSDSMSEDCLYLSIYTPAHSHEGSNLPVMVWIHGGALVFGMASLYDGSMLAALENVVVVII 175

  Fly   154 SFGLGPLGFASTGDRHLPGNYGLKDQRLALQWIKKNIAHFGGMPDNIVLIGHSAGGASAHLQLLH 218
            .:.||.|||.||||:|..||:|..||..||:|:::|||||||.||.:.:.|.||||.|....::.
Human   176 QYRLGVLGFFSTGDKHATGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSLVVS 240

  Fly   219 EDFKHLAKGAISVSGNALDPWVIQQGGRRRAFELGRIVGCGHTNVSAELKDCLKSKPASDIVSAV 283
            ...:.|..|||..||.||.|.:|.......:..:..:..|...: |..|..||:.|...:|::..
Human   241 PISQGLFHGAIMESGVALLPGLIASSADVISTVVANLSACDQVD-SEALVGCLRGKSKEEILAIN 304

  Fly   284 RSFLVFSYVPFSAFGPVVEPSDAPDAFLTEDPRAVIKSGKFAQVPWAVTYTTEDGGYNAAQLLER 348
            :        ||.....||:     ..||...|:.::.|..|..||
Human   305 K--------PFKMIPGVVD-----GVFLPRHPQELLASADFQPVP-------------------- 336

  Fly   349 NKLTGESWIDLLNDRWFDW-APYLLFYRDAKKTIKDMD----------------------DLSFD 390
             .:.|      :|:..|.| .|.::...|   |.|:||                      ||
Human   337 -SIVG------VNNNEFGWLIPKVMRIYD---TQKEMDREASQAALQKMLTLLMLPPTFGDL--- 388

  Fly   391 LRQQYLADRRFSVESYWNVQRMFTDVLFKNSVPSAIDLHRKYGKSPVYSFVYDNPTDSGVGQLLS 455
            ||::|:.|...........|.|..|.:|  .:|:....|.:..::|||.:.:.:..     ..|.
Human   389 LREEYIGDNGDPQTLQAQFQEMMADSMF--VIPALQVAHFQCSRAPVYFYEFQHQP-----SWLK 446

  Fly   456 NRTDVHFGTVHGDDFFLIFNTAAYRTGIR--PDEEVISKKFIGMLEDFALN 504
            |....|....|||:...:|.:......|:  .:||.:|:|.:....:||.|
Human   447 NIRPPHMKADHGDELPFVFRSFFGGNYIKFTEEEEQLSRKMMKYWANFARN 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	144/506 (28%)
Est-P	NP_788501.1	Aes	<107..>240	CDD:223730	60/133 (45%)
CES2	NP_001352334.1	COesterase	30..538	CDD:306613	144/506 (28%)
CES2	NP_001352334.1	Prevents secretion from ER. /evidence=ECO:0000255	556..559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142677
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.840