DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-P and Ces2f

DIOPT Version :9

Sequence 1:	NP_788501.1	Gene:	Est-P / 39393	FlyBaseID:	FBgn0000594	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_001073334.2	Gene:	Ces2f / 71903	MGIID:	1919153	Length:	561	Species:	Mus musculus

Alignment Length:	534	Identity:	152/534 - (28%)
Similarity:	238/534 - (44%)	Gaps:	92/534 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LCLTLLWIAALE-SEADPLIVEITNGKIRGKDNGL------YYSYESIPNAEHPTGALRF---EA 62
            |.:.||.:..|: |||.| |.....|::|||...|      .:::..||.|:.|.|.|||   ||
Mouse    17 LLVLLLHVKGLDSSEASP-IRNTHTGQVRGKFVHLTDIKAGAHNFLGIPFAKPPVGPLRFAPPEA 80

  Fly    63 PQPYSHHWTDVFNATQSPVECMQWNQFIN-ENNKLMG--------DEDCLTVSIYKPKKPNR-SS 117
            |:|    |:.|.:.|..|..|:|.:..:| |..|::.        .||||.::||.|..... |:
Mouse    81 PEP----WSGVRDGTSQPAMCLQNDDIVNLEGLKIIKMILPPFSMSEDCLYLNIYTPAHAQEGSN 141

  Fly   118 FPVVVLLHGGAFMFGSGSIYGHDSIMREGTLLVVKISFGLGPLGFASTGDRHLPGNYGLKDQRLA 182
            .||:|.||||..:.|..|:|....:.....::||...:.||..||.||||....||:|..||..|
Mouse   142 LPVMVWLHGGGLVAGMASMYDGSVLAATEDVVVVVTQYRLGIPGFYSTGDEQARGNWGFLDQTAA 206

  Fly   183 LQWIKKNIAHFGGMPDNIVLIGHSAGGASAHLQLLHEDFKHLAKGAISVSGNALDPWVIQQGGRR 247
            |.|:::|||:|||.||::.|.|.||||.|....:|....:.|...||..||.||.|.:|......
Mouse   207 LHWVQQNIANFGGNPDSVTLFGQSAGGTSVSFHVLSPVSQGLFHRAIMESGVALLPTIIPDSPEM 271

  Fly   248 RAFELGRIVGCGHTNVSAELKDCLKSKPASDIVSAVRSFLVFSYVPFSAFGPVVEPSDAPDAFLT 312
            ...::..:.|| .|:.|..|..||:.|..::|::..::|         .|.|.|    ....||.
Mouse   272 IFTKVANLSGC-ETSNSEALVRCLRGKSEAEILAMSKAF---------RFMPAV----VDGKFLP 322

  Fly   313 EDPRAVIKSGKFAQVPWAVTYTTEDGGY---------NAAQLLERN------KLTGESWIDLLND 362
            ..|:.::.|..|..||..:....::.|:         ...:.:.||      |:|.|..:
Mouse   323 RHPKKLLASADFHPVPSIIGVNNDEYGWIIPKIFKFSQTIRKINRNNLKAIMKITTEQMM----- 382

  Fly   363 RWFDWAPYLLFYRDAKKTIKDMDDLSFDLRQQYLADRRFSVESYWNVQRMFTDVL--FKNSVPSA 425
                 .|            .:..||   |.::||.|    .|..|.:|..|.:::  |...:|:.
Mouse   383 -----LP------------SECGDL---LIEEYLRD----TEDPWTLQMQFREMIGDFLIIIPAL 423

  Fly   426 IDLHRKYGKSPVYSFVYDNPTDSGVGQLLSNRTDVHFGTVHGDDFFLIFNTAAY--RTGIRPDEE 488
            .....:...:|||.:.:.:.:     .||......|....|||:.:|||.:..:  :.....:|:
Mouse   424 QVARFQRSHAPVYFYEFQHRS-----SLLKYFRPWHVKADHGDELYLIFGSFFWGLKFSFTAEEK 483

  Fly   489 VISKKFIGMLEDFA 502
            ::|:|.:....:||
Mouse   484 LLSRKMMKYWANFA 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	144/515 (28%)
Est-P	NP_788501.1	Aes	<107..>240	CDD:223730	56/133 (42%)
Ces2f	NP_001073334.2	COesterase	32..540	CDD:395084	146/519 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832657
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.840