DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Est-P and TG

DIOPT Version :9

Sequence 1:NP_788501.1 Gene:Est-P / 39393 FlyBaseID:FBgn0000594 Length:544 Species:Drosophila melanogaster
Sequence 2:NP_003226.4 Gene:TG / 7038 HGNCID:11764 Length:2768 Species:Homo sapiens


Alignment Length:585 Identity:140/585 - (23%)
Similarity:237/585 - (40%) Gaps:119/585 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 IAALESEAD-PLIVEITNGKIRGKDNGLYY--------SYESIPNAEHPTGALRFEAPQPYSHHW 70
            |:.|..||. |.:...|:|::.|:...:..        .:..:|.|..|....||:||:|.  :|
Human  2189 ISLLSYEASVPSVPISTHGRLLGRSQAIQVGTSWKQVDQFLGVPYAAPPLAERRFQAPEPL--NW 2251

  Fly    71 TDVFNATQSPVECMQWNQFINENNKLMGDEDCLTVSIYKPKK--PNRSSFPVVVLLHG------- 126
            |..::|::....|  |......:......||||.::::.|:.  ||.|   |:|..|.       
Human  2252 TGSWDASKPRASC--WQPGTRTSTSPGVSEDCLYLNVFIPQNVAPNAS---VLVFFHNTMDREES 2311

  Fly   127 -------GAFMFGSGSIYGHDSIMREGTLLVVKISFGLGPLGFASTGDRHLPGNYGLKDQRLALQ 184
                   |:|:...|:            |:||..|:.:|..||.|:|...:.||:||.||..||.
Human  2312 EGWPAIDGSFLAAVGN------------LIVVTASYRVGVFGFLSSGSGEVSGNWGLLDQVAALT 2364

  Fly   185 WIKKNIAHFGGMPDNIVLIGHSAGG--ASAHLQLLHEDFKHLAKGAISVSGNALDPWVI--QQGG 245
            |::.:|..|||.|..:.|.....|.  ||.||.........|.:.|:.:.|:||.|..:  .:..
Human  2365 WVQTHIRGFGGDPRRVSLAADRGGADVASIHLLTARATNSQLFRRAVLMGGSALSPAAVISHERA 2429

  Fly   246 RRRAFELGRIVGCGHTNVSAELKDCLKSKPASDIVSAVRSFLVFSYVPFSAFGPVVEPSDAPDAF 310
            :::|..|.:.|.|..:: |.|:..||:.|||:.:..|....|..| .||..:|||::     ..|
Human  2430 QQQAIALAKEVSCPMSS-SQEVVSCLRQKPANVLNDAQTKLLAVS-GPFHYWGPVID-----GHF 2487

  Fly   311 LTEDPRAVIKSGKFAQVPWAVTYTTEDGGYNAAQLLE-----RNKLTGESWIDLLNDRWFDWAPY 370
            |.|.|...:|...:.:|...:..:.:||..|.|:.::     |.:.:.::               
Human  2488 LREPPARALKRSLWVEVDLLIGSSQDDGLINRAKAVKQFEESRGRTSSKT--------------- 2537

  Fly   371 LLFYRDAKKTIKDMDDLSFDLRQQYLADRRFSVESYWNVQRMFTDVLFKNS------VPSAIDLH 429
             .||:..:.::...|.   |.|.:..|...:|:|...:....|:..| :|:      :...||:.
Human  2538 -AFYQALQNSLGGEDS---DARVEAAATWYYSLEHSTDDYASFSRAL-ENATRDYFIICPIIDMA 2597

  Fly   430 RKYGKSPVYS-FVYDNPTDSGVG--QLLSNRTDVHFGTVHGDDFFLIFNTAAYRTGIRPDEEVIS 491
            ..:.|....: |:|..|.:.|.|  :||:   ||.|..  |..|:     .||......:|:.:|
Human  2598 SAWAKRARGNVFMYHAPENYGHGSLELLA---DVQFAL--GLPFY-----PAYEGQFSLEEKSLS 2652

  Fly   492 KKFIGMLEDFALNDKGTLTFGECNFQNNV-----------------NSKEYQVLRISRNACKNEE 539
            .|.:.....|..:......:   .|...|                 |.||:..|..:|...|..:
Human  2653 LKIMQYFSHFIRSGNPNYPY---EFSRKVPTFATPWPDFVPRAGGENYKEFSELLPNRQGLKKAD 2714

  Fly   540  539
            Human  2715  2714

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Est-PNP_788501.1 Esterase_lipase 26..537 CDD:238191 134/569 (24%)
Aes <107..>240 CDD:223730 45/150 (30%)
TGNP_003226.4 TY 33..92 CDD:238114
TY 95..160 CDD:238114
TY 300..358 CDD:238114
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 521..545
Thyroglobulin_1 599..658 CDD:395039
Thyroglobulin_1 662..724 CDD:395039
TY 729..>776 CDD:412186
TY <892..922 CDD:412186
TY 1004..1073 CDD:238114
TY 1077..1145 CDD:238114
TY 1149..1210 CDD:238114
Type II. /evidence=ECO:0000269|PubMed:8797845 1456..1469
Ephrin_rec_like 1465..1510 CDD:400166
Type II. /evidence=ECO:0000269|PubMed:8797845 1470..1486
Type II. /evidence=ECO:0000269|PubMed:8797845 1487..1503
TY 1520..1567 CDD:214561
Type IIIA. /evidence=ECO:0000269|PubMed:8797845 1603..1723
Type IIIB. /evidence=ECO:0000269|PubMed:8797845 1724..1892
Type IIIA. /evidence=ECO:0000269|PubMed:8797845 1893..1995
Type IIIB. /evidence=ECO:0000269|PubMed:8797845 1996..2129
Type IIIA. /evidence=ECO:0000269|PubMed:8797845 2130..2187
Cholinesterase-like (ChEL). /evidence=ECO:0000250|UniProtKB:O08710 2188..2768 140/585 (24%)
COesterase 2197..2718 CDD:395084 136/577 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2727..2768
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165142707
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.930

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