DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Est-P and LOC688542

DIOPT Version :9

Sequence 1:	NP_788501.1	Gene:	Est-P / 39393	FlyBaseID:	FBgn0000594	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	XP_038954018.1	Gene:	LOC688542 / 688542	RGDID:	1587637	Length:	559	Species:	Rattus norvegicus

Alignment Length:	551	Identity:	160/551 - (29%)
Similarity:	254/551 - (46%)	Gaps:	105/551 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSIFKRLLCLTLLWIAAL--------ESEADPLIVEITNGKIRG-----KDNGL-YYSYESIPNA 51
            |:::||..||..:....|        :..|.| |.....|::||     ||..: .:::..||.|
  Rat     1 MTLYKRPGCLNAVTCGLLLLVLHVRGQDSASP-IRNTHTGQVRGSLVHVKDTDIDVHTFLGIPFA 64

  Fly    52 EHPTGALRF---EAPQPYSHHWTDVFNATQSPVECMQ-WNQFINENNKLMG--------DEDCLT 104
            :.|.|.|||   |||:|    |:.|.:||..|..|:| .|...:|:.|:|.        .||||.
  Rat    65 KPPVGPLRFAPPEAPEP----WSGVRDATSHPAMCLQNDNMMGSEDMKIMKLILPPISMSEDCLY 125

  Fly   105 VSIYKPKKPNR-SSFPVVVLLHGGAFMFGSGSIYGHDSIMREGTLLVVKISFGLGPLGFASTGDR 168
            ::||.|...:. |:.||:|.:||||...|..|:|....:.....::||.|.:.||.|||.||||.
  Rat   126 LNIYAPTHAHEGSNLPVMVWIHGGALTVGMASMYDGSMLAATEDVVVVTIQYRLGVLGFFSTGDE 190

  Fly   169 HLPGNYGLKDQRLALQWIKKNIAHFGGMPDNIVLIGHSAGGASAHLQLLHEDFKHLAKGAISVSG 233
            |..||:|..||..||:|:::|||||||.|:.:.:.|.||||.|....::....:.|..|||..||
  Rat   191 HARGNWGYLDQVAALRWVQQNIAHFGGNPNRVTIFGESAGGTSVSSHVVSPMSQGLFHGAIMESG 255

  Fly   234 NALDPWVIQQGGRRRAFELGRIVGCGHTNVSAELKDCLKSKPASDIVSAVRSFLVFSYVPFSAFG 298
            ..:.|.:|.:........:..:.||...: |..|..||:.|..::|:...:   ||..:|....|
  Rat   256 VVVLPDLISRSSEMVYRIVANLSGCAAVD-SETLMQCLRGKSEAEILDINK---VFKIIPAVVDG 316

  Fly   299 PVVEPSDAPDAFLTEDPRAVIKSGKFAQVPWAVTYTTEDGG------YNAAQLLERNKLTGESWI 357
                      .||.:.|:.::.|..|.:||..:....::.|      :::||.:|  ::|.::
  Rat   317 ----------EFLPKHPQELLASANFHRVPSIIGINNDEYGWILPMIFDSAQKIE--EITRKT-- 367

  Fly   358 DLLNDRWFDWAPYLLFYRDAKKTIKDM------DDLSFDLRQQYLADRRFSVESYWNVQRMFTDV 416
                      .|.:|     |.|...|      .||   |.::|:.|    .|....:|..|.::
  Rat   368 ----------LPTVL-----KSTALKMMLPPECGDL---LMEEYMGD----TEDPKTLQAQFREM 410

  Fly   417 L--FKNSVPSAIDLHRKYGKSPVYSFVYDNPTDSGVGQLLSNRTDV---HFGTVHGDDFFLIFNT 476
            :  |...:|:....|.:...:|||.:.:.:.:        |...||   |....|||:.||:|
  Rat   411 MGDFMFVIPALQVAHFQRSHAPVYFYEFQHRS--------SFFKDVKPPHVKADHGDEVFLVF-- 465

  Fly   477 AAYRTG-IR----PDEEVISKKFIGMLEDFA 502
             .|..| |:    .:||::|:|.:....:||
  Rat   466 -GYLVGDIKFPHTEEEELLSRKIMKYWANFA 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	152/518 (29%)
Est-P	NP_788501.1	Aes	<107..>240	CDD:223730	56/133 (42%)
LOC688542	XP_038954018.1	COesterase	30..538	CDD:395084	154/522 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910