DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Est-P and LOC679149

DIOPT Version :9

Sequence 1:	NP_788501.1	Gene:	Est-P / 39393	FlyBaseID:	FBgn0000594	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_001094469.1	Gene:	LOC679149 / 679149	RGDID:	1591847	Length:	561	Species:	Rattus norvegicus

Alignment Length:	531	Identity:	149/531 - (28%)
Similarity:	242/531 - (45%)	Gaps:	91/531 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LLWIAALESEADPLIVEITN---GKIRGKDNGL------YYSYESIPNAEHPTGALRF---EAPQ 64
            ||.:..::.:..|....|.|   |::|||.:.:      .:::..||.|:.|.|.|||   |||:
  Rat    18 LLLLIHVQGQHSPESSPIRNTHIGQVRGKLDHVKDTKAGVHTFLGIPFAKPPVGPLRFAPPEAPE 82

  Fly    65 PYSHHWTDVFNATQSPVECMQWNQFIN-ENNKLMG--------DEDCLTVSIYKPKKPNR-SSFP 119
            |    |:.|.:.|..|..|:|....|| |..|.|.        .||||.::||.|...:. |:.|
  Rat    83 P----WSGVRDGTSQPAMCLQNLDVINAEGLKEMKLKLPPVSMSEDCLYLNIYAPAHAHEGSNLP 143

  Fly   120 VVVLLHGGAFMFGSGSIYGHDSIMREGTLLVVKISFGLGPLGFASTGDRHLPGNYGLKDQRLALQ 184
            |:|.:|||..|.|..|:|....:.....|:||.|.:.||.|||.||||.|..||:|..||..||:
  Rat   144 VMVWIHGGGLMTGMASMYDGSLLTVNEDLVVVTIQYRLGVLGFFSTGDEHARGNWGYLDQVAALR 208

  Fly   185 WIKKNIAHFGGMPDNIVLIGHSAGGASAHLQLLHEDFKHLAKGAISVSGNALDPWVIQQGGRRRA 249
            |:::|||||||.||.:.:.|.||||......::....:.|..|||..||.||.|::|.......:
  Rat   209 WVQQNIAHFGGNPDRVTIFGESAGGTCVSTHVVSPMSQGLFHGAIMESGVALLPYLIADTSEMFS 273

  Fly   250 FELGRIVGCGHTNVSAELKDCLKSKPASDIVSAVRSFLVFSYVPFSAFGPVVE--PSDAPDAFLT 312
            ..:.::.||...: |..|..||::|..::|:               |...||:  |:.....||.
  Rat   274 TMVAKVSGCEAMD-SEALVHCLRAKSEAEIL---------------AINKVVQMVPAVVDGEFLP 322

  Fly   313 EDPRAVIKSGKFAQVPWAVTYTTEDGGY------NAAQLLERNKLTGESWIDLLNDRWFDWAPYL 371
            ..|:.::.|..|..||..:....::.|:      ...|:::  :|:.|:...:|
  Rat   323 RHPKELLASEDFRPVPSIIGVNNDEYGWTIPLVMGTTQMIK--ELSRENLQAIL----------- 374

  Fly   372 LFYRDAKKTIKDM------DDLSFDLRQQYLADRRFSVESYWNVQRMFTDVL--FKNSVPSAIDL 428
                  |||...:      .||   |.::|:.|    :|....:|..||:::  |...:|:....
  Rat   375 ------KKTTAQLMLPLECSDL---LMEEYMGD----IEDPKTLQAQFTELMEDFMFVIPALQVA 426

  Fly   429 HRKYGKSPVYSFVYDNPTDSGVGQLLSNRTDVHFGTVHGDDFFLIFNTAAY--RTGIRPDEEVIS 491
            |.:...:|||.:.:.:..     ..|.:....|....|||:...:|....:  :|....:|:::|
  Rat   427 HFQCSHAPVYFYEFQHQI-----TFLKDIRPPHVKADHGDEIPFVFGYFFWDMKTDFTEEEKLLS 486

  Fly   492 KKFIGMLEDFA 502
            ::.:....:||
  Rat   487 RRMMKYWANFA 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	146/517 (28%)
Est-P	NP_788501.1	Aes	<107..>240	CDD:223730	59/133 (44%)
LOC679149	NP_001094469.1	COesterase	31..540	CDD:278561	146/518 (28%)
LOC679149	NP_001094469.1	Aes	<130..>233	CDD:223730	48/102 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336180
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.840