DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-P and Bche

DIOPT Version :9

Sequence 1:	NP_788501.1	Gene:	Est-P / 39393	FlyBaseID:	FBgn0000594	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_075231.1	Gene:	Bche / 65036	RGDID:	619996	Length:	597	Species:	Rattus norvegicus

Alignment Length:	578	Identity:	161/578 - (27%)
Similarity:	251/578 - (43%)	Gaps:	90/578 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LLWIAAL-------ESEADPLIVEITNGKIRGKD----NGLYYSYESIPNAEHPTGALRFEAPQP 65
            ||||..|       .:|.| :|:....|::||..    .|...::..||.|:.|.|:|||:.|||
  Rat     8 LLWILLLCMLFGKSHTEED-VIITTKTGRVRGLSMPILGGTVTAFLGIPYAQPPLGSLRFKKPQP 71

  Fly    66 YSHHWTDVFNATQSPVEC----------MQWNQFINENNKLMGDEDCLTVSIYKP-KKPNRSSFP 119
            . :.|.||:|||:....|          .|.::..|.|..|  .||||.::::.| .||..::
  Rat    72 L-NKWPDVYNATKYANSCYQNIDQAFPGFQGSEMWNPNTNL--SEDCLYLNVWIPVPKPKNAT-- 131

  Fly   120 VVVLLHGGAFMFGSGS--IYGHDSIMREGTLLVVKISFGLGPLGF-ASTGDRHLPGNYGLKDQRL 181
            |:|.::||.|..|:.|  :|....:.|...::||.:::.:|.||| |..|:...|||.||.||:|
  Rat   132 VMVWVYGGGFQTGTSSLPVYDGKFLTRVERVIVVSMNYRVGALGFLAFPGNSEAPGNMGLFDQQL 196

  Fly   182 ALQWIKKNIAHFGGMPDNIVLIGHSAGGASAHLQLLHEDFKHLAKGAISVSGNALDPWVIQ--QG 244
            |||||::|||.|||.|.::.|.|.|||.||..|.||......|...||..||::..||.::  :.
  Rat   197 ALQWIQRNIAAFGGNPKSVTLFGESAGAASVSLHLLCPQSYPLFTRAILESGSSNAPWAVKHPEE 261

  Fly   245 GRRRAFELGRIVGCGHTNVSAELKDCLKSKPASDIVSAVRSFLVFSYVPFSAFGPVVEPSDAPDA 309
            .|.|...|.:.:||...| ..|:..||:||...:|:...:..|....:....|||.|:..
  Rat   262 ARNRTLTLAKFIGCSKEN-EKEIITCLRSKDPQEILLNEKLVLPSDSIRSINFGPTVDGD----- 320

  Fly   310 FLTEDPRAVIKSGKFAQVPWAVTYTTEDGG----YNAAQLLERNK--LTGESWIDLLNDRWFDWA 368
            |||:.|..:::.||.......|....::|.    |.|....:.|.  :|...:.:.|| .:|...
  Rat   321 FLTDMPHTLLQLGKVKTAQILVGVNKDEGTAFLVYGAPGFSKDNDSLITRREFQEGLN-MYFPGV 384

  Fly   369 PYL-----LFYRDAKKTIKDMDDLSFDLRQQYLADRRFSVESYWNVQRMFTDVLFK-NSVPSAID 427
            ..|     |||                 ...:|.|:  :.|.|   :..|.|::.. |.:..|::
  Rat   385 SSLGKEAILFY-----------------YVDWLGDQ--TPEVY---REAFDDIIGDYNIICPALE 427

  Fly   428 LHRKYGKSPVYSFVYDNPTDSGVGQLLSNRTD-----VHFGTVHGDDFFLIFN-TAAYRTGIRPD 486
            ..:|:.:..:.:|.|          ...:|:.     ...|.:||.:...:|. ....|......
  Rat   428 FTKKFAELEINAFFY----------YFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRVNYTRA 482

  Fly   487 EEVISKKFIGMLEDFALNDKGTLTFGECNFQNNVNSKEYQVLRISRNACKNEEYARFP 544
            ||:.|:..:....:||.......|.|.........|.|.:.|.::....|.....|.|
  Rat   483 EEIFSRSIMKTWANFAKYGHPNGTQGNSTVWPVFTSTEQKYLTLNTEKSKINSKLRAP 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	151/548 (28%)
Est-P	NP_788501.1	Aes	<107..>240	CDD:223730	56/136 (41%)
Bche	NP_075231.1	COesterase	21..545	CDD:278561	156/565 (28%)
		Aes	<120..>272	CDD:223730	60/153 (39%)
		AChE_tetra	560..594	CDD:285837
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910