DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-P and cel.2

DIOPT Version :9

Sequence 1:	NP_788501.1	Gene:	Est-P / 39393	FlyBaseID:	FBgn0000594	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_001020344.2	Gene:	cel.2 / 565117	ZFINID:	ZDB-GENE-061110-10	Length:	551	Species:	Danio rerio

Alignment Length:	568	Identity:	155/568 - (27%)
Similarity:	235/568 - (41%)	Gaps:	133/568 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 GKIRGKDNG---LYYS--YESIPNAEHPTGALRFEAPQPYSHHWTDVFNATQSPVECMQWNQFIN 91
            |.::||.:.   |.|.  ::.||.|. |.|.|:...|.|   .|..|..||:....|:|.|....
Zfish    31 GMVQGKSHSVGLLRYMDVFKGIPFAA-PPGRLQKPVPHP---GWEGVLKATEYSKRCIQLNLLQT 91

  Fly    92 ENNKLMGDEDCLTVSIYKPK-KPNRSSFPVVVLLHGGAFMFGSGS--------IYGHDSIMREGT 147
            :.   ||.||||.::|:.|: |....:.||:|.::||.|:.|.|.        :|..:.|...|.
Zfish    92 DT---MGSEDCLYLNIWVPQGKTVSYNLPVMVFIYGGGFLLGGGQGANFLDNYLYDGEEIADRGN 153

  Fly   148 LLVVKISFGLGPLGFASTGDRHLPGNYGLKDQRLALQWIKKNIAHFGGMPDNIVLIGHSAGGASA 212
            ::||..::.:|.:||.||||...||||||.||..|:.|:.:||..|||.||||.:.|.|||..|.
Zfish   154 VIVVTFNYRVGSMGFLSTGDADAPGNYGLWDQHAAISWVHRNIKAFGGNPDNITIFGESAGSTSV 218

  Fly   213 HLQLLHEDFKHLAKGAISVSGNALDPWVIQQGGRRRAFELGRIVGCGHTNVSAELKDCLK--SKP 275
            :.|::....|.|.:.|||.||.||.||.|.:..|:.|.|:.:.|||   ...:.:..||:  ...
Zfish   219 NFQIISPKNKGLIRRAISQSGVALCPWAINRNPRKFAEEIAKKVGC---PTDSGMVACLRRTDPK 280

  Fly   276 ASDIVSAVRSFLVFSYVPFSAFGPVVEP---SDAPDA-FLTEDPRAVIKSGKFAQVPW------- 329
            |..:...||       :..||..|:|..   |...|. |:.::|..:.  |..|.:.:
Zfish   281 AVTLAGKVR-------LATSATEPIVHNLYLSPVIDGDFIPDEPDTLF--GNAADIDYIAGVNDM 336

  Fly   330 ---------------AVTYTTEDGGYNAAQLLERNKLTGESWIDLLNDRWFDWA--PYLLFYRDA 377
                           |:..|||:.....|..|.::: ..::.|....:...:|.  |.   ..|.
Zfish   337 DGHIFATLDIPSINNALATTTEEEVQALATALSKDR-GQDAGIATFQEYTVNWGSKPN---KEDI 397

  Fly   378 KKTIKDMDDLSFDLRQQYLADRRFSVESYWNVQRMFTDVLFKNSVPSAIDLHRKYGKSP-VYSFV 441
            |||:.:|:                            ||.:|.....:|:.||....||. .||::
Zfish   398 KKTVVEME----------------------------TDYIFLVPTQTALYLHSDNAKSARTYSYL 434

  Fly   442 YDNPTDSGVGQLLSNRTDVH---FGTVHGDDFFLIFNTAAYRT--GIRPDEEVISKKFIGMLEDF 501
            :..          |:|..:.   .|..|.|:...:|. ..:.|  |..|....:||..|....:|
Zfish   435 FSE----------SSRIPIFPLWMGADHADELQYVFG-KPFTTPLGYFPRHRDVSKYMIAYWTNF 488

  Fly   502 ALNDKGTLTFGEC-------NFQN------NVNSKEYQVLRISRNACK 536
            |  ..|....||.       .|.|      ::|:|      |:.|:.|
Zfish   489 A--QTGNPNTGESKVPVTWPEFSNPGHQYLDINNK------INTNSVK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	155/568 (27%)
Est-P	NP_788501.1	Aes	<107..>240	CDD:223730	58/141 (41%)
cel.2	NP_001020344.2	COesterase	26..539	CDD:306613	155/568 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575537
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222591at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.750