DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-P and ces2b

DIOPT Version :9

Sequence 1:	NP_788501.1	Gene:	Est-P / 39393	FlyBaseID:	FBgn0000594	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	XP_021326380.1	Gene:	ces2b / 561967	ZFINID:	ZDB-GENE-041014-96	Length:	1611	Species:	Danio rerio

Alignment Length:	565	Identity:	158/565 - (27%)
Similarity:	249/565 - (44%)	Gaps:	74/565 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KRLLCLTLLWIAALESEADPLIVEITNGKIR-------GKDNGLYYSYESIPNAEHPTGALRFEA 62
            |....:|..:...|....:..:|....|.:|       |||: :..||.:||.|:.|.|.||...
Zfish   535 KHFTFVTQTFPRILSERKEGPVVNTKLGSLRGSYMMAKGKDS-VISSYFAIPFAKSPVGPLRLTP 598

  Fly    63 PQPYSHHWTDVFNATQSPVECMQWNQFINENNKLMG--------DEDCLTVSIYKPKKP-NRSSF 118
            ||| :..|..|.:||:.|..|:|..:.:.:....|.        .||||.::||.|.|| :....
Zfish   599 PQP-ADAWQGVRDATKQPPMCLQPKEVMVDLLATMPLKTEFPEVSEDCLYLNIYTPSKPGDNKKL 662

  Fly   119 PVVVLLHGGAFMFGSGSIYGHDSIMREGTLLVVKISFGLGPLGFASTGDRHLPGNYGLKDQRLAL 183
            ||:|.:|||...|||.||:...::.....::||.:.:.||.|||.||||.|.||||||.||..||
Zfish   663 PVMVWIHGGGLAFGSASIFDAHALAAYQDIVVVMVQYRLGLLGFFSTGDEHAPGNYGLLDQVAAL 727

  Fly   184 QWIKKNIAHFGGMPDNIVLIGHSAGGASAHLQLLHEDFKHLAKGAISVSGNALDPWVIQQGGRRR 248
            ||:::||..|||.|.::.:.|.||||.||.|.:|.....:|...||:.||.|....::.......
Zfish   728 QWVQENIHSFGGDPGSVTVFGESAGGVSASLLVLSPLSANLFHRAIAESGTAAMNAIMSPDPLST 792

  Fly   249 AFELGRIVGCGHTNVSAELK--DCLKSKPASDIVSAVRSFLVFSYVPFSAFGPVVEPSDAPDAFL 311
            |..||.:.||   ::|:..|  ||:......||:...|..::.      .||..|:     ..||
Zfish   793 ARSLGNVSGC---DISSTKKIVDCVMQMTEEDILKIAREQVLL------RFGVTVD-----GQFL 843

  Fly   312 TEDPRAVIKSGKFAQVPWAVTYTTEDGGYNAAQLLERNKLTGESWID-LLNDRWFDWAPYLLFYR 375
            .:....:::|.:|::||.....|.:|||:...:.     :....|.| :..|:..   |:|..|.
Zfish   844 PKSVDELLQSQEFSKVPLMTGVTDDDGGFTLPEF-----IAPPGWRDGMTKDQIM---PFLPTYN 900

  Fly   376 DAKKTIKDMDD--LSFDLRQQYLADRRFSVESYWNVQRMFTDVLFKNSVPSAIDLHRKYGKSPVY 438
                  .|:.|  |:..:.::||......::.....:.:..|..|........:.||..| :|||
Zfish   901 ------YDLQDPGLAEIVLKEYLGATTDKIKIRDGFREIVGDFFFNLPARKLANYHRDTG-APVY 958

  Fly   439 SFVYDNPTDSGVGQLLSNRTDVHFGTVHGDDFFLIFNTAAYRTG---------IRPDEEVISKKF 494
            .:.:.:|     ..:..|:.....|..|||:...:|   .|..|         :..:|:.:.|..
Zfish   959 MYEFQHP-----AYIFQNKRPSFVGCDHGDELLFVF---GYCFGNGHIKVEGELSKEEQELCKTT 1015

  Fly   495 IGMLEDFAL--NDKGTLTFGECNFQNNVNSKEYQVLRISRNACKN 537
            :....:||.  |..|.   |...:.......||..:.:.:.:.||
Zfish  1016 MAYWGNFARTGNPNGP---GLVEWPKYGAEAEYLGIGLEQKSSKN 1057

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	153/542 (28%)
Est-P	NP_788501.1	Aes	<107..>240	CDD:223730	61/133 (46%)
ces2b	XP_021326380.1	COesterase	27..539	CDD:306613	1/3 (33%)
		COesterase	553..1065	CDD:306613	155/547 (28%)
		COesterase	1079..1592	CDD:306613
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910