DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-P and nlgn4xa

DIOPT Version :9

Sequence 1:	NP_788501.1	Gene:	Est-P / 39393	FlyBaseID:	FBgn0000594	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	XP_021330915.1	Gene:	nlgn4xa / 561122	ZFINID:	ZDB-GENE-100309-2	Length:	844	Species:	Danio rerio

Alignment Length:	581	Identity:	154/581 - (26%)
Similarity:	238/581 - (40%)	Gaps:	146/581 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LCLTLLWIAALESEADPLIVEITN-GKIRGKDN-------GLYYSYESIPNAEHPTGALRFEAPQ 64
            :.|...|:|...::..|::.  || ||:||...       |....|..||.|..|||..||:.|:
Zfish    27 IVLAAAWLAITWAQQHPIVT--TNYGKLRGLKTPLPNEILGPVEQYLGIPYALPPTGERRFQPPE 89

  Fly    65 PYSHHWTDVFNATQSPVECMQWNQFINENNKLMGD---------------------EDCLTVSIY 108
            | ...|..:.||||....|   .||: |:..|:.|                     ||||.::||
Zfish    90 P-PMSWPGIRNATQFAPVC---PQFL-EDRFLLNDMLPVWFTANLDTVVTYVQDQSEDCLYLNIY 149

  Fly   109 KPKK---PNRSS-------------------FPVVVLLHGGAFMFGSGSIYGHDSIMREGTLLVV 151
            .|.:   .|:..                   .||:|.:|||::|.|:|::.....:...|.::||
Zfish   150 VPTEDVGANKGDDFTNNEGGENKDIHDENGLRPVMVYIHGGSYMEGTGNMIDGSILASYGNVIVV 214

  Fly   152 KISFGLGPLGFASTGDRHLPGNYGLKDQRLALQWIKKNIAHFGGMPDNIVLIGHSAGGASAHLQL 216
            .:::.||.|||.||||:...|||||.||..||:|||:||..|.|.|..:.:.|..||.:...|..
Zfish   215 TLNYRLGVLGFLSTGDQAAKGNYGLLDQIQALRWIKENIQAFKGDPKRVTIFGSGAGASCVSLLT 279

  Fly   217 LHEDFKHLAKGAISVSGNALDPWVIQQGGRRRAFELGRIVGCGHTNVSAELKDCLKSKPASDIVS 281
            |....:.|.:.||..||.||..|.:.....:....|...|||...: |.:|.:||::|...:::.
Zfish   280 LSHYSEDLFQKAIIQSGTALSSWAVNYQPAKYTRILAEKVGCNMLD-SIDLVECLQNKNYKELIE 343

  Fly   282 AVRSFLVFSYVPFS----AFGPVVEPSDAPDAFLTEDPRAVIKSGKFAQVPWAVTYTTEDGGYNA 342
                    .|:..:    |||||::....||     ||:.:::.|:|               .|.
Zfish   344 --------QYITQAKYHIAFGPVIDGDVIPD-----DPQILMEQGEF---------------LNY 380

  Fly   343 AQLLERNKLTGESWIDLL---------NDRWF---DWAPYLLFYRDAKKTIKDMDDLSFDLRQQY 395
            ..:|..|:..|..::|.:         ||..|   |:..:|..|.:.|.|:::      .::..|
Zfish   381 DIMLGVNQGEGFKFVDGIVDSEDGVSANDFDFAVSDFVDHLYGYPEGKDTLRE------TIKFMY 439

  Fly   396 L--ADRRFSVESYWNVQRMFTDVLFKNSVPSAIDLHRKYGKSPVYSFVYDNPTDSGVGQLLSNRT 458
            .  ||:.........:..:|||..:.....:..|||.:|| ||.|.:.:.:...|.:....|:
Zfish   440 TDWADKENPETRRKTLVALFTDHQWVAPAVATADLHAQYG-SPTYFYAFYHHCQSEMKPSWSD-- 501

  Fly   459 DVHFGTVHGDDFFLIFNTAAYRTGIRPDEEVISKKFIGMLEDFALNDKGTLTFGECNFQNN 519
                 :.|||:...:|.                   |.||        |......|||..|
Zfish   502 -----SAHGDEVPYVFG-------------------IPML--------GPTDLFNCNFSKN 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	150/563 (27%)
Est-P	NP_788501.1	Aes	<107..>240	CDD:223730	54/154 (35%)
nlgn4xa	XP_021330915.1	COesterase	43..605	CDD:306613	151/565 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575546
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.740