DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-P and nlgn2a

DIOPT Version :9

Sequence 1:	NP_788501.1	Gene:	Est-P / 39393	FlyBaseID:	FBgn0000594	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	XP_009301340.1	Gene:	nlgn2a / 556158	ZFINID:	ZDB-GENE-090918-2	Length:	828	Species:	Danio rerio

Alignment Length:	613	Identity:	156/613 - (25%)
Similarity:	232/613 - (37%)	Gaps:	205/613 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LTLLWIA-----ALESEADP----LIVEITNGKIRGKDN-------GLYYSYESIPNAEHPTGAL 58
            :.|.|:|     |.....||    ..|....||:||...       |....|..:|.|..|.|..
Zfish    23 IALFWLALWITLASCQRIDPGTKYPTVTTNYGKLRGIKKELNNEILGPVEQYLGVPYATAPIGDR 87

  Fly    59 RFEAPQ-PYSHHWTDVFNATQSPVECMQ-------------W-------------NQFINENNKL 96
            ||:.|: |.|  |.:|.||||....|.|             |             ||
Zfish    88 RFQPPEAPGS--WQEVRNATQFAPVCPQNVHGVLPEIMLPVWFTDSLDVAATYIQNQ-------- 142

  Fly    97 MGDEDCLTVSIYKP-------KKPNRSSF--------------PVVVLLHGGAFMFGSGSIYGHD 140
              .||||.:::|.|       ||.:.|:.              ||::.:|||::|.|:|:::...
Zfish   143 --SEDCLYLNVYVPTEDGPLTKKHDESTLNRPRDEDIRDRRKKPVMLFIHGGSYMEGTGNMFDAS 205

  Fly   141 SIMREGTLLVVKISFGLGPLGFASTGDRHLPGNYGLKDQRLALQWIKKNIAHFGGMPDNIVLIGH 205
            .:...|.::||.:::.||.|||.||||:...|||||.||..||:|:.:||.||||.|:.|.:.|.
Zfish   206 VLAAYGNVIVVTMNYRLGVLGFLSTGDQSAKGNYGLLDQIQALRWLNENIGHFGGDPERITIFGS 270

  Fly   206 SAGGASAHLQLLHEDFKHLAKGAISVSGNALDPWVIQQGGRRRAFELGRIVGC--GHTNVSAELK 268
            .||.:..:|.:|....:.|.:.||:.||:|:..|.|.....:....|.|.|||  |.|   |:|.
Zfish   271 GAGASCVNLLILSHHSEGLFQRAIAQSGSAISSWSISYQPLKYTKILARKVGCTYGET---ADLV 332

  Fly   269 DCLKSKPASDIV----SAVRSFLVFSYVPFSAFGPVVEPSDAPDAFLTEDPRAVIKSGKFAQVPW 329
            |||:.|...::|    ...|..:        |||||::....||     ||..:::.|:|.....
Zfish   333 DCLRRKNFRELVDQDIQPARYHI--------AFGPVMDGDVVPD-----DPEILMQQGEFLNYDL 384

  Fly   330 AVTYT-------TEDGG-------------YNAAQLLERNKLTGESWIDLLND----RWFDWAPY 370
            .:...       .:|||             |..:..:: |........|:|.:    .:.|||
Zfish   385 LIGVNQGEGLKFVDDGGTESEEGISAAAFDYTISNFVD-NLYGYPKGKDILRETIKFMYTDWA-- 446

  Fly   371 LLFYRDAKKTIKDMDDLSFDLRQQYLADRRFSVESYWNVQRMFTDVLFKNSVPSAIDLHRKYGKS 435
                        |.|  :.::|::.|.             .:|||..:.....:...||..| :|
Zfish   447 ------------DRD--NGEMRRKTLL-------------ALFTDHQWVAPAIATAKLHADY-QS 483

  Fly   436 PVYSFVYDNPTDSGVGQLLSNRTDVHFGT---------VHGDDFFLIFNTAAYRTGIRPDEEVIS 491
            |||.:.:.:                |..|         .|||:...:|..
Zfish   484 PVYFYTFYH----------------HCQTETRPEWADAAHGDEIPYVFGV--------------- 517

  Fly   492 KKFIGMLEDFALNDKGTLTFGECNFQNN 519
             ..||..:.|           .|||..|
Zfish   518 -PMIGATDLF-----------PCNFSKN 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	150/588 (26%)
Est-P	NP_788501.1	Aes	<107..>240	CDD:223730	54/153 (35%)
nlgn2a	XP_009301340.1	COesterase	47..608	CDD:306613	150/589 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575541
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.740