Protein Alignment Est-P and NLGN3

DIOPT Version :9

• Sequence 1: NP_788501.1
• Gene: Est-P / 39393
• FlyBaseID: FBgn0000594
• Length: 544
• Species: Drosophila melanogaster
• Sequence 2: NP_851820.1
• Gene: NLGN3 / 54413
• HGNCID: 14289
• Length: 848
• Species: Homo sapiens
• Alignment Length: 607
• Identity: 157/607 - (25%)
• Similarity: 240/607 - (39%)
• Gaps: 170/607 - (28%)

  Fly     6 RLLCLTLLWIAAL----ESEADPLIVEITNGKIRG-------KDNGLYYSYESIPNAEHPTGALR 59
            |.|||| ||..:|    .::|....|....||:||       :..|....|..:|.|..|.|..|
Human    20 RSLCLT-LWFLSLALRASTQAPAPTVNTHFGKLRGARVPLPSEILGPVDQYLGVPYAAPPIGEKR 83

  Fly    60 FEAPQPYSHHWTDVFNATQSPVECMQ-------------W--------NQFINENNKLMGDEDCL 103
            |..|:| ...|:.:.|||..|..|.|             |        ..:|.|.|     ||||
Human    84 FLPPEP-PPSWSGIRNATHFPPVCPQNIHTAVPEVMLPVWFTANLDIVATYIQEPN-----EDCL 142

  Fly   104 TVSIYKP------------KKPNR-------------------------------SSFPVVVLLH 125
            .:::|.|            :|||:                               .:.||:|.:|
Human   143 YLNVYVPTEDVKRISKECARKPNKKICRKGGSGAKKQGEDLADNDGDEDEDIRDSGAKPVMVYIH 207

  Fly   126 GGAFMFGSGSIYGHDSIMREGTLLVVKISFGLGPLGFASTGDRHLPGNYGLKDQRLALQWIKKNI 190
            ||::|.|:|::.....:...|.::|:.:::.:|.|||.||||:...|||||.||..||:|:.:||
Human   208 GGSYMEGTGNMIDGSILASYGNVIVITLNYRVGVLGFLSTGDQAAKGNYGLLDQIQALRWVSENI 272

  Fly   191 AHFGGMPDNIVLIGHSAGGASAHLQLLHEDFKHLAKGAISVSGNALDPWVIQQGGRRRAFELGRI 255
            |.|||.|..|.:.|...|.:...|..|....:.|.:.||..||:||..|.:.....:....|...
Human   273 AFFGGDPRRITVFGSGIGASCVSLLTLSHHSEGLFQRAIIQSGSALSSWAVNYQPVKYTSLLADK 337

  Fly   256 VGCGHTNV--SAELKDCLKSKPASDIVSAVRSFLVFSYVPFSAFGPVVEPSDAPDAFLTEDPRAV 318
            |||   ||  :.::.|||:.|.|.::|.  :......|  ..|||||::....||     ||..:
Human   338 VGC---NVLDTVDMVDCLRQKSAKELVE--QDIQPARY--HVAFGPVIDGDVIPD-----DPEIL 390

  Fly   319 IKSGKFAQVPWAVTYTTEDGGYNAAQLLERNKLTGESWI-------DLLNDRWFDWA-----PYL 371
            ::.|:|               .|...:|..|:..|..::       |.::...||::     ..|
Human   391 MEQGEF---------------LNYDIMLGVNQGEGLKFVEGVVDPEDGVSGTDFDYSVSNFVDNL 440

  Fly   372 LFYRDAKKTIKDMDDLSFDLRQQYL--ADRRFSVESYWNVQRMFTDVLFKNSVPSAI--DLHRKY 432
            ..|.:.|.|:::      .::..|.  |||.........:..:|||..:..  ||.:  |||.:|
Human   441 YGYPEGKDTLRE------TIKFMYTDWADRDNPETRRKTLVALFTDHQWVE--PSVVTADLHARY 497

  Fly   433 GKSPVYSFVYDNPTDSGVGQLLSNRTDVHFGTVHGDDFFLIFNTAAYRTGIRPDEEVISKKFIGM 497
            | ||.|.:.:.:...|.:....|:       ..|||:...:|..                ..:|.
Human   498 G-SPTYFYAFYHHCQSLMKPAWSD-------AAHGDEVPYVFGV----------------PMVGP 538

  Fly   498 LEDFALNDKGTLTFGECNFQNN 519
            .:.|           .|||..|
Human   539 TDLF-----------PCNFSKN 549

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	148/583 (25%)
		Aes	<107..>240	CDD:223730	53/175 (30%)
NLGN3	NP_851820.1	COesterase	36..624	CDD:278561	149/590 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	170..195		0/24 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	645..694

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142570
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740