DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-P and Cesl1

DIOPT Version :9

Sequence 1:	NP_788501.1	Gene:	Est-P / 39393	FlyBaseID:	FBgn0000594	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	XP_038953870.1	Gene:	Cesl1 / 501232	RGDID:	1565666	Length:	596	Species:	Rattus norvegicus

Alignment Length:	564	Identity:	161/564 - (28%)
Similarity:	236/564 - (41%)	Gaps:	115/564 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SIFKRLLCLTLLWIAALE------SEADPLIVEITNGKIRGKDNGLYYSYE----------SIPN 50
            ||..|.:||..|::.:|.      :.:.|.:|:...||:.||    |.|.|          .:|.
  Rat    30 SICPRKMCLRSLFLVSLATCVVCGNPSSPPVVDTMKGKVLGK----YASLEGVTQSVAVFLGVPF 90

  Fly    51 AEHPTGALRFEAPQPYSHHWTDVFNATQSPVECMQ---WNQFINE---NNK----LMGDEDCLTV 105
            |:.|.|:|||..||| :..|:.|.|.|..|..|.|   ..|.:|:   |.|    |...||||.:
  Rat    91 AKPPLGSLRFAPPQP-AEPWSFVKNTTTYPPMCSQDATKGQRMNDLLTNRKEKVHLQFSEDCLYL 154

  Fly   106 SIYKPKKPNRSS-FPVVVLLHGGAFMFGSGSIYGHDSIMREGTLLVVKISFGLGPLGFASTGDRH 169
            :||.|....:.| .||:|.:|||....|..|.|....:.....::||.|.:.||..||.||||.|
  Rat   155 NIYTPADFTKDSRMPVMVWIHGGGLTQGGASTYDGQVLSAYENVVVVAIQYRLGIWGFFSTGDEH 219

  Fly   170 LPGNYGLKDQRLALQWIKKNIAHFGGMPDNIVLIGHSAGGASAHLQLLHEDFKHLAKGAISVSGN 234
            ..||:|..||..||.|::.|||:|||.|.::.:.|.||||.|..:.:|....|:|...|||.||.
  Rat   220 SRGNWGHLDQVAALHWVQDNIANFGGDPGSVTIFGESAGGFSVSVLVLSPLSKNLYHRAISESGV 284

  Fly   235 ALDPWVIQQGGRRRAFELGRIVGCGHTNVSAELKDCLKSKPASDIVSAVRSFLVFSYVPFSA--- 296
            .|...:..:..|..|.::..:.|| .|..||.:..||:.|...:::..:..   .:.:..|:
  Rat   285 VLITELFTKDVRPAAKQIADMAGC-KTTTSAIIVHCLRQKTEEELLEIMEK---MNLIKLSSQRD 345

  Fly   297 -------FGPVVEPSDAPDAFLTEDPRAVIKSGKFAQVPWAVTYTTEDGGYNAAQLLE----RNK 350
                   ...|::     |..|.:||:.::....|..||:.|....::.|:....::.    ..|
  Rat   346 TKESYHFLSTVID-----DVVLPKDPKEILAEKNFNTVPYIVGINKQECGWLLPTMMRFVPPDVK 405

  Fly   351 LTGESWIDLLNDRWF--------DWAPYLLFYRDAKKTIKDMDDLSFDLRQQYLADRRFSVESYW 407
            |..:..|.||..  |        |..|..:     :|..|..|| ...:|...||
  Rat   406 LDKKMAIMLLEK--FASIYGIPEDIIPVAI-----EKYRKGSDD-PIKIRDGILA---------- 452

  Fly   408 NVQRMFTDVLFKNSVPSAI---DLHRKYGKSPVYSFVY---------DNPTDSGVGQLLSNRTDV 460
                ...|.||  .:||.:   | ||..| :|.|.:.|         ..|.|. ||.
  Rat   453 ----FIGDALF--CIPSVMVSRD-HRDAG-APTYVYEYQYYPSFSSPQRPKDV-VGD-------- 500

  Fly   461 HFGTVHGDDFFLIFNTAAYRTGIRPDEEVISKKFIGMLEDFALN 504
                 |.||.:.:|.....|.|...:|..:||..:....:||.|
  Rat   501 -----HADDVYSVFGAPILRDGASEEEIKLSKMVMKFWANFARN 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	153/534 (29%)
Est-P	NP_788501.1	Aes	<107..>240	CDD:223730	55/133 (41%)
Cesl1	XP_038953870.1	COesterase	57..580	CDD:395084	154/537 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.100