DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-P and Ces2h

DIOPT Version :9

Sequence 1:	NP_788501.1	Gene:	Est-P / 39393	FlyBaseID:	FBgn0000594	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_001037723.1	Gene:	Ces2h / 498940	RGDID:	1560889	Length:	558	Species:	Rattus norvegicus

Alignment Length:	523	Identity:	144/523 - (27%)
Similarity:	230/523 - (43%)	Gaps:	100/523 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 IRGKDNGLYYSYESIPNAEHPTGALRF---EAPQPYSHHWTDVFNATQSPVECMQWNQFIN-ENN 94
            ::|.|.|: :|:..||.|:.|.|.|||   |||:|    |:.|.:.|..|..|:|....:| :..
  Rat    47 MKGLDVGV-HSFLGIPFAKPPIGPLRFAPPEAPEP----WSGVRDGTSHPAMCLQDITAMNMQAF 106

  Fly    95 KLMG--------DEDCLTVSIYKPKKPNR-SSFPVVVLLHGGAFMFGSGSIYGHDSIMREGTLLV 150
            ||:.        .||||.::||.|...:. |:.||:|.:||||.:.|..|:|....:.....::|
  Rat   107 KLLKLTLPLIPMSEDCLYLNIYTPNHAHEGSNLPVMVWIHGGALVIGMASLYDGSMLAAMENVVV 171

  Fly   151 VKISFGLGPLGFASTGDRHLPGNYGLKDQRLALQWIKKNIAHFGGMPDNIVLIGHSAGGASAHLQ 215
            |.|.:.||.|||.||||:|..||:|..||..||.|:::|||||||.||.:.:.|.||||.|....
  Rat   172 VTIQYRLGVLGFFSTGDQHARGNWGYLDQVAALHWVQQNIAHFGGNPDRVTIFGESAGGTSVSSH 236

  Fly   216 LLHEDFKHLAKGAISVSGNALDPWVIQQGGRRRAFELGRIVGCGHTNVSAELKDCLKSKPASDIV 280
            ::....:.|..|||..||.||...:|..........:..:.||...: |..|.:||:.|...:|:
  Rat   237 VVSPMSRGLFHGAIMESGVALMSSLISVSSDVVYRTVANLSGCEQVD-SKALVNCLRGKSEEEIM 300

  Fly   281 SAVRSFLVFSYVPFSAFGPVVEPSDAPDAFLTEDPRAVIKSGKFAQVP-----------WAV--T 332
            |..::|.:.|.:             ....||...|:.::.|..|..:|           |.:  :
  Rat   301 SINKAFRIISGI-------------VDGIFLPRHPKELLASADFHPIPSIIGVNNDEYGWIIPSS 352

  Fly   333 YTTEDGGYNAAQLLERNKLTGESWIDLLNDR--WFDWAPYLLFYRDAKKTIKDMDDLSFDLRQQY 395
            .||.|         .:.|:..:....:|..|  ...|.|             :..||   |.::|
  Rat   353 MTTTD---------SKKKMDRQMVQAILQKRVAQMMWPP-------------EFSDL---LLEEY 392

  Fly   396 LADRRFSVESYWNVQRMFTDVL--FKNSVPSAIDLHRKYGKSPVYSFVYDN-PTDSGVGQLLSNR 457
            :.|.    |....:|..|.:::  |...:|:....|.:...:|||.:.:.: |:      ...:.
  Rat   393 MGDS----EDPQFLQVQFKEMMEDFTFVIPALQVAHFQRSNAPVYFYEFQHRPS------FFKDS 447

  Fly   458 TDVHFGTVHGDDFFLIFNT--AAYRTGIRPDEEVISKKFIGMLEDFALNDKGTLTFGECNFQNNV 520
            ...|....|||:...||.:  ...:..:..:||::|::.:....:||.             |.|.
  Rat   448 KPPHVKADHGDEILFIFRSFWGGTQVDLTEEEELLSRRMMKYWANFAR-------------QGNP 499

  Fly   521 NSK 523
            ||:
  Rat   500 NSE 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	144/523 (28%)
Est-P	NP_788501.1	Aes	<107..>240	CDD:223730	58/133 (44%)
Ces2h	NP_001037723.1	COesterase	30..537	CDD:278561	144/523 (28%)
Ces2h	NP_001037723.1	Aes	<127..>230	CDD:223730	47/102 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336372
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.840