DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-P and ACHE

DIOPT Version :9

Sequence 1:	NP_788501.1	Gene:	Est-P / 39393	FlyBaseID:	FBgn0000594	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_001354847.1	Gene:	ACHE / 43	HGNCID:	108	Length:	681	Species:	Homo sapiens

Alignment Length:	561	Identity:	158/561 - (28%)
Similarity:	241/561 - (42%)	Gaps:	128/561 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LCLTLLW-----IAALESEADPLIVEITNGKIRG----KDNGLYYSYESIPNAEHPTGALRFEAP 63
            |.|.|||     :.|...|...|:|.:..|::||    ...|...::..||.||.|.|..||..|
Human    84 LLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPVSAFLGIPFAEPPMGPRRFLPP 148

  Fly    64 QPYSHHWTDVFNATQSPVECMQW----------NQFINENNKLMGDEDCLTVSIYKPKKPNRSSF 118
            :| ...|:.|.:||.....|.|:          .:..|.|.:|  .||||.::::.|.....|..
Human   149 EP-KQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNREL--SEDCLYLNVWTPYPRPTSPT 210

  Fly   119 PVVVLLHGGAFMFGSGSIYGHDS---IMREGTLLVVKISFGLGPLGF-ASTGDRHLPGNYGLKDQ 179
            ||:|.::||.|..|:.|:..:|.   :..|.|:| |.:::.:|..|| |..|.|..|||.||.||
Human   211 PVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVL-VSMNYRVGAFGFLALPGSREAPGNVGLLDQ 274

  Fly   180 RLALQWIKKNIAHFGGMPDNIVLIGHSAGGASAHLQLLHEDFKHLAKGAISVSGNALDPWVIQQG 244
            ||||||:::|:|.|||.|.::.|.|.|||.||..:.||....:.|...|:..||....||.....
Human   275 RLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGM 339

  Fly   245 G--RRRAFELGRIVGC---GHTNVSAELKDCLKSKPASDIVS------AVRSFLVFSYVPFSAFG 298
            |  ||||.:|..:|||   |......||..||:::||..:|:      ...|...||:|
Human   340 GEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVLPQESVFRFSFV------ 398

  Fly   299 PVVEPSDAPDAFLTEDPRAVIKSGKFAQVPWAVTYTTEDGGYNAAQLLERNKLTGESWIDLLNDR 363
            |||:..     ||::.|.|:|.:|.|..:...|....::|.|
Human   399 PVVDGD-----FLSDTPEALINAGDFHGLQVLVGVVKDEGSY----------------------- 435

  Fly   364 WFDWAPYLLFYRDAKKTIKDMDDLSFDLRQQYLADRRFSVESY--------------W------- 407
                  :|::  .|....||.:.|.  .|.::||..|..|...              |
Human   436 ------FLVY--GAPGFSKDNESLI--SRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPEDPA 490

  Fly   408 NVQRMFTDVLFKNSV--PSAIDLHRKYGK-SPVYSFVYDNPTDSGVGQLLSNRTDVHFGTVHGDD 469
            .::...:||:..::|  |.|....|...: :.||::|:::...:     ||  ..:..|..||.:
Human   491 RLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRAST-----LS--WPLWMGVPHGYE 548

  Fly   470 FFLIFNTAAYRTGIRPD--------EEVISKKFIGMLEDFA 502
            ...||       ||..|        |::.:::.:....:||
Human   549 IEFIF-------GIPLDPSRNYTAEEKIFAQRLMRYWANFA 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	150/538 (28%)
Est-P	NP_788501.1	Aes	<107..>240	CDD:223730	54/136 (40%)
ACHE	NP_001354847.1	COesterase	104..630	CDD:395084	151/541 (28%)
ACHE	NP_001354847.1	AChE_tetra	645..678	CDD:400834
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142703
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.940