DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-P and CG10175

DIOPT Version :9

Sequence 1:	NP_788501.1	Gene:	Est-P / 39393	FlyBaseID:	FBgn0000594	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_001287487.1	Gene:	CG10175 / 42773	FlyBaseID:	FBgn0039084	Length:	707	Species:	Drosophila melanogaster

Alignment Length:	523	Identity:	160/523 - (30%)
Similarity:	246/523 - (47%)	Gaps:	60/523 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 IAALESEADPLIVEITN-GKIRGK-------DNGLYYSYESIPNAEHPTGALRFEAPQPYSHHWT 71
            :.:|..|.:  ||..|: ||:||:       :.|.|||::.:.....||||.||.|.:| ...|:
  Fly   145 VRSLRKERE--IVATTSLGKVRGRYQKYRSGERGGYYSFKGMRYGAPPTGARRFRAAEP-EKPWS 206

  Fly    72 DVFNATQSPVECMQWNQFINENNKLMGDEDCLTVSIYKPKKP------NRSSFPVVVLLHGGAFM 130
            .:.:|::....|...|..:   :...||||||.|:::..:.|      .:...||:|.||||.|.
  Fly   207 GIRDASREGQSCPHKNMIL---DTFKGDEDCLFVNVFTTQMPKDDESAEQPKLPVMVWLHGGGFS 268

  Fly   131 FGSGS--IYGHDSIMREGTLLVVKISFGLGPLGFASTGDRHLPGNYGLKDQRLALQWIKKNIAHF 193
            ||||:  :||.|.::.|..:||. :::.||||||.:.|. ..|||.|||||.|||:|::.|||.|
  Fly   269 FGSGNSFLYGPDYLVAEDIVLVT-LNYRLGPLGFLTAGP-DAPGNQGLKDQVLALKWVRDNIAAF 331

  Fly   194 GGMPDNIVLIGHSAGGASAHLQLLHEDFKHLAKGAISVSGNALDPWVIQQGGRRRAFELGRIVGC 258
            ||.|:.:.:.|.|||.:|..|.||....|.|...|||.||:||:||.:.....:||..|...:|.
  Fly   332 GGDPNQVTIFGESAGASSVQLLLLSSQAKGLFHRAISQSGSALNPWSMSASSSQRAARLAANLGY 396

  Fly   259 GHTNVSAELKDCLKSKPASDIVSAVRSFLVFS------YVPFSAFGPVVEPSDAPDA-------- 309
            ...|.:.::.|.|:..||..:|.|..:.:...      .:||.   ||||.....|:
  Fly   397 VGANKTEDILDFLRRVPAMKLVEAAPTTITAEDQRNNIGLPFV---PVVEGYWNQDSQEEQFYEE 458

  Fly   310 -FLTEDPRAVIKSGKFAQVPWAVTYTTEDGGYNA--AQLLERNKLTGESWIDLLNDRWFDWAPYL 371
             |||:.|..:..|..|..   .|.|.|   |||.  |.|..|........:.::.:.:....|
  Fly   459 PFLTQHPSDMYHSQNFNS---DVAYMT---GYNTHEAMLFIRRLRKNPQLLSIIENDFGRLVP-- 515

  Fly   372 LFYRDAKKTIKDMDDLSFDLRQQYLADRRFSVESYWNVQRMFTDVLFKNSVPSAIDLHRKYGKSP 436
               :|...| :..|.::.::|..||..:...:||...:..:.||::|...:......|.|:|.:|
  Fly   516 ---QDLNVT-ESHDRVTREIRSFYLGSKHVGIESVDEMIALLTDLMFLQGIRRTARNHAKFGNAP 576

  Fly   437 VYSFVYDNPTDSGVGQLLSNRTDVHFGTVHGDDFFLIFNTAAYRTGIRPD--EEVISKKFIGMLE 499
            ||  :|....|..:|...........|..|||:...:|....:...:.|.  |..:..:.:.|..
  Fly   577 VY--MYRFSFDGSLGLYKRMLGIPRPGVCHGDELGYLFKFGFFNLSLDPKSMEVQVKNRMVRMWT 639

  Fly   500 DFA 502
            :||
  Fly   640 NFA 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	158/512 (31%)
Est-P	NP_788501.1	Aes	<107..>240	CDD:223730	63/140 (45%)
CG10175	NP_001287487.1	COesterase	157..695	CDD:278561	156/509 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222591at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	9	8.970