DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-P and CG4757

DIOPT Version :9

Sequence 1:	NP_788501.1	Gene:	Est-P / 39393	FlyBaseID:	FBgn0000594	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_001262469.1	Gene:	CG4757 / 41330	FlyBaseID:	FBgn0027584	Length:	550	Species:	Drosophila melanogaster

Alignment Length:	587	Identity:	153/587 - (26%)
Similarity:	256/587 - (43%)	Gaps:	114/587 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLCLTLLWIAALESEADPLIVEITN--GKIRGKD----NGL-YYSYESIPNAEHPTGALRFEAPQ 64
            :|.|.::.:..|.:.:..|.:|:..  |::||.:    .|: ::::..|..||.|.|.|||..||
  Fly     1 MLMLFVVELLVLLASSSVLSIEVDTELGRVRGANLTSRLGVNFHAFRGIRYAEPPLGDLRFVNPQ 65

  Fly    65 PYSHHWTDVFNATQSPVECMQ-WNQFINENNKLMGDEDCLTVSIY-KPKKPNRSSFPVVVLLH-G 126
            |.......:|:|::....|.| |:...:.:      ||||.:::| |..|..|   ||:|.|| |
  Fly    66 PVKPWSPKIFDASEDGPMCPQPWDNMTDVS------EDCLRLNVYTKDLKGRR---PVIVFLHPG 121

  Fly   127 GAFMFGSGSIY--GHDSIMREGTLLVVKISFGLGPLGFASTGDRHLPGNYGLKDQRLALQWIKKN 189
            |.::|...|.|  |.:..|....:| |.:::.||.|||.:||.:..|||.|||||.|||:||:::
  Fly   122 GFYVFSGQSKYLAGPEHFMDRDCVL-VSLNYRLGSLGFLATGSKEAPGNAGLKDQVLALRWIQQH 185

  Fly   190 IAHFGGMPDNIVLIGHSAGGASAHLQLLHEDFKHLAKGAISVSGNALDPWVIQQGGRRRAFELGR 254
            |..|||.||::.|:|:|||..|..|.:|....:.|....|.:|.....|...:....:.|.....
  Fly   186 IQRFGGDPDSVTLLGYSAGSISVALHMLSPMSRGLFHRGICMSAAPYGPVKYKDNDLQLAKRQAG 250

  Fly   255 IVGCGHTNVSAELKDCLKSKPASDIVSAVRSFLVFSYVPFSAFGPVVEPSDAPDAFLTEDPRAVI 319
            ::.|...:: .|:.:|::.||..|.||.......|.:.|...:..|||.....:.:|.|.|....
  Fly   251 LLKCPQESI-GEMVECMRRKPYLDYVSTYNGMFEFGWNPVLNWRIVVEKDFGQERYLIESPFKTA 314

  Fly   320 KSGKFAQVPWAVTYTTEDGGYNAAQLLERNKLTGESWIDLLNDRWFDWAPYLLFY-------RDA 377
            :.|.|.:|. .:|..||....:.|....||    ||.::..|..|..:|...|..       |.|
  Fly   315 RRGDFHKVA-LITGITEFEFLSGAFFDLRN----ESIVNRYNRDWEHYASIALLLEQNSTQSRAA 374

  Fly   378 KKTIKDMDDLSFDLRQQYLADRRFSVE---SYWNVQRMFTDVLFKNSVPSAIDLHRKYGKSPVYS 439
            .:.          .|::|:.:....:|   |...:..:.:|.|...|....:.|...:  :|:|:
  Fly   375 SRV----------FREKYMPESLDKLEYPKSLKGMGELLSDALIGVSFHRFLQLMSPH--TPIYT 427

  Fly   440 FVY---------DNPTDSGVGQLLSNRTDVHFGTVHGDDFFLIFNTAAYRTGIRPDE------EV 489
            :::         .||         .|:..:  |.||.|:...:|:.......::.::      |:
  Fly   428 YLFRYKGRYTFLKNP---------DNQQTI--GPVHHDELIYLFHVGLLIPLLKREDPENFMIEL 481

  Fly   490 ISKKFIGMLEDFA---------------LN-------DKGTLTFGECNFQNNVNSK-------EY 525
            :::.:|    :||               ||       |||.|..|     ||:.:|       .|
  Fly   482 LTRMWI----EFAQKGDPHNKNDEYLKGLNWPLYNAQDKGYLEIG-----NNLTAKSGGFFLNRY 537

  Fly   526 QV 527
            |:
  Fly   538 QI 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	149/568 (26%)
Est-P	NP_788501.1	Aes	<107..>240	CDD:223730	56/136 (41%)
CG4757	NP_001262469.1	COesterase	15..540	CDD:278561	150/573 (26%)
CG4757	NP_001262469.1	Aes	40..>204	CDD:223730	68/173 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440365
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG25788
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	10	9.900