DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-P and alpha-Est1

DIOPT Version :9

Sequence 1:	NP_788501.1	Gene:	Est-P / 39393	FlyBaseID:	FBgn0000594	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_524269.3	Gene:	alpha-Est1 / 40909	FlyBaseID:	FBgn0015568	Length:	565	Species:	Drosophila melanogaster

Alignment Length:	525	Identity:	154/525 - (29%)
Similarity:	235/525 - (44%)	Gaps:	92/525 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 IVEITNGKIRGK------DNGLYYSYESIPNAEHPTGALRFEAPQPYSHHWTDVFNATQSPVECM 84
            :|...:|::||.      |..:|:::|.||.|:.|.|.|||.|||| .|.|..|.:.|....:.|
  Fly    34 VVCTRDGQVRGHRRRTLYDEEMYFAFEGIPFAQPPVGELRFRAPQP-PHPWLGVRDCTYPRAKPM 97

  Fly    85 QWNQFINENNKLMGDEDCLTVSIYKPKKPNRSSFPVVVLLHGGAFMFGSG--SIYGHDSIMREGT 147
            | ..|:  .:.:.|.||||.:::|..:..:....||:|.::||.|.||..  ..|..|..|:: .
  Fly    98 Q-KHFV--LSIVEGSEDCLYLNVYSKRLRSDKPLPVIVWIYGGGFQFGEAGRDFYSPDYFMQQ-D 158

  Fly   148 LLVVKISFGLGPLGFASTGDRHL--PGNYGLKDQRLALQWIKKNIAHFGGMPDNIVLIGHSAGGA 210
            ::||..::.:|.|||.|..||.|  |||.|||||.:||:||.:|||.|.|.|.||.::|.|||.|
  Fly   159 VVVVTFNYRVGALGFLSLADRDLDVPGNAGLKDQVMALRWISQNIAQFNGDPQNITVMGESAGAA 223

  Fly   211 SAHLQLLHEDFKHLAKGAISVSGNALDPWVIQQGGRRRAFELGRIVGCGHTNVSAELKDCLKSKP 275
            |.|..:..|..:.|...||..||:....|..:..| |.|:.|...:|...:....|:...|:..|
  Fly   224 SVHALMTTEQTRGLFHKAIMQSGSMFCEWANEPSG-RWAYRLACQLGYSGSENEKEVFRYLQKAP 287

  Fly   276 ASDIVSAVRSFLVFS------YVPFSAFGPVVEPSDAPDAFLTEDPRAVIKSGKFAQVPWAVTYT 334
            ||::  |.:...:.|      ||.| .|.|||||....|..|....|.::...      |
  Fly   288 ASEM--AAQGITLVSQEERRQYVLF-PFTPVVEPYITRDCVLPRCHREMLPEA------W----- 338

  Fly   335 TEDGGYNAAQLLERNKLTGESWIDLLNDRWFDWAPYLLFYRDAKKTIKDMDDL--SFDL------ 391
                |.:...:|..|...|                 |..|   :.|:.|.:.:  :|::
  Fly   339 ----GNDLPLILGGNSFEG-----------------LFSY---QSTLHDEEHMLSAFEVLIPREI 379

  Fly   392 ----RQQYLAD--RRFSVESYWNVQR---MFTDVLFKNSVPSA-IDLHR----KYGKSP-----V 437
                .|.:|.|  |:|.|:::.:..|   .|.:.|...||... ..:||    :...:|     :
  Fly   380 REKSTQSHLKDLLRQFKVDNFDDATRGRMEFNECLHILSVKHFWHGIHRTVLARLSHAPATPTYL 444

  Fly   438 YSFVYDNPTDSGVGQLLSNRTDVHF-GTVHGDDF-FLIFNTAAYRTGIRPDEEVISKKFIGMLED 500
            |.|..|:|..:...|::..:   |. |..|.||. :|.::..|.:......|....::.:||...
  Fly   445 YRFDVDSPHFNHFRQVMCGK---HVRGVSHADDLSYLFYHILANKVDKSSMEYQTIQRLVGMWVA 506

  Fly   501 FALND 505
            ||.||
  Fly   507 FARND 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	154/525 (29%)
Est-P	NP_788501.1	Aes	<107..>240	CDD:223730	55/136 (40%)
alpha-Est1	NP_524269.3	COesterase	28..541	CDD:278561	154/525 (29%)
alpha-Est1	NP_524269.3	Aes	<117..>233	CDD:223730	49/116 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440371
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	8	7.790