DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-P and alpha-Est7

DIOPT Version :9

Sequence 1:	NP_788501.1	Gene:	Est-P / 39393	FlyBaseID:	FBgn0000594	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_524261.1	Gene:	alpha-Est7 / 40901	FlyBaseID:	FBgn0015575	Length:	572	Species:	Drosophila melanogaster

Alignment Length:	541	Identity:	149/541 - (27%)
Similarity:	252/541 - (46%)	Gaps:	90/541 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 ESEADPLIVEITNGKIRG-KDNGL----YYSYESIPNAEHPTGALRFEAPQ-PYSHHWTDVFNAT 77
            :|..:.::.:...|::|| |...|    |:|:|.||.|:.|.|.|||:||| |..  |..|.:.:
  Fly    27 QSTNETVVADTEYGQVRGIKRLSLYDVPYFSFEGIPYAQPPVGELRFKAPQRPIP--WERVRDCS 89

  Fly    78 QSPVECMQWNQFINENNKLMGDEDCLTVSIYKPK-KPNRSSFPVVVLLHGGAFMFGSGS--IYGH 139
            |...:.:| .||:.:  |:.|.||||.:::|... ||:::. ||:|.:|||.|:.|..:  .||.
  Fly    90 QPKDKAVQ-VQFVFD--KVEGSEDCLYLNVYTNNVKPDKAR-PVMVWIHGGGFIIGEANREWYGP 150

  Fly   140 DSIMREGTLLVVKISFGLGPLGFAS--TGDRHLPGNYGLKDQRLALQWIKKNIAHFGGMPDNIVL 202
            |..|:|..:||. |.:.||.|||.|  :.:.::|||.|||||.|||:|||.|.|.|||.|:.|.:
  Fly   151 DYFMKEDVVLVT-IQYRLGALGFMSLKSPELNVPGNAGLKDQVLALKWIKNNCASFGGDPNCITV 214

  Fly   203 IGHSAGGASAHLQLLHEDFKHLAKGAISVSGNALDPWVIQQGGRRRAFELGRIVGCGHTNVSAEL 267
            .|.||||||.|..:|.:..:.|....|..||:|:.||..........:.:.::||....:...::
  Fly   215 FGESAGGASTHYMMLTDQTQGLFHRGILQSGSAICPWAYNGDITHNPYRIAKLVGYKGEDNDKDV 279

  Fly   268 KDCLKSKPASDIVSAVRSFLV----FSYVPFSAFGPVVEPSDAPDAFLTEDPRAVIKSGKFAQVP 328
            .:.|::..|.|::....:.|.    .:.:.| ||||.:||...|:..:::.|:.::|:.....:|
  Fly   280 LEFLQNVKAKDLIRVEENVLTLEERMNKIMF-AFGPSLEPFSTPECVISKPPKEMMKTAWSNSIP 343

  Fly   329 WAVTYTTEDGGYNAAQLLERNKLTGESWIDLLN---------DRWFDWAPYLLFYRDAKKTIKDM 384
            ..:..|:.:|      ||         |:..:.         |....:.|..|...:..|  :.:
  Fly   344 MFIGNTSYEG------LL---------WVPEVKLMPQVLQQLDAGTPFIPKELLATEPSK--EKL 391

  Fly   385 DDLSFDLRQQYLADRRFSVESYWNVQRMFTDVLFKNSVPSAIDLHRKY---GKSPVYSFVYDNPT 446
            |..|..:|..:......:.::|.::..::..|.     |:...:|.::   ..:|||.:.||..:
  Fly   392 DSWSAQIRDVHRTGSESTPDNYMDLCSIYYFVF-----PALRVVHSRHAYAAGAPVYFYRYDFDS 451

  Fly   447 DS------------GVGQLLSNRTDVHFGTVHGDDFFLIFNTAAYRTGIRPDEEVIS-KKFIGML 498
            :.            ||.           |..|.||....|::...|...:...|..: ::.:|:.
  Fly   452 EELIFPYRIMRLGRGVK-----------GVSHADDLSYQFSSLLARRLPKESREYRNIERTVGIW 505

  Fly   499 EDFA---------LNDKGTLT 510
            ..||         :|...|||
  Fly   506 TQFAATGNPYSEKINGMDTLT 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-P	NP_788501.1	Esterase_lipase	26..537	CDD:238191	148/534 (28%)
Est-P	NP_788501.1	Aes	<107..>240	CDD:223730	61/137 (45%)
alpha-Est7	NP_524261.1	COesterase	27..514	CDD:278561	145/527 (28%)
alpha-Est7	NP_524261.1	Aes	<116..>221	CDD:223730	49/106 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440374
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	8	7.790